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Protein
Submitted name:

SHC-transforming protein 1

Gene

Shc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ephrin receptor binding Source: MGI
  2. insulin-like growth factor receptor binding Source: MGI
  3. insulin receptor binding Source: MGI
  4. neurotrophin TRKA receptor binding Source: MGI
  5. protein kinase binding Source: GO_Central

GO - Biological processi

  1. actin cytoskeleton reorganization Source: MGI
  2. activation of MAPK activity Source: MGI
  3. angiogenesis Source: MGI
  4. epidermal growth factor receptor signaling pathway Source: MGI
  5. heart development Source: MGI
  6. insulin receptor signaling pathway Source: GO_Central
  7. MAPK cascade Source: MGI
  8. regulation of cell proliferation Source: MGI
  9. single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SHC-transforming protein 1Imported
Gene namesi
Name:Shc1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:98296. Shc1.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3Z2I8.
ExpressionAtlasiD3Z2I8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3Z2I8.
SMRiD3Z2I8. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
[Graphical view]
PRINTSiPR00629. SHCPIDOMAIN.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3Z2I8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV
60 70 80 90 100
SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK
110 120 130 140 150
PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ DTAEYVAYVA
160 170 180 190 200
KDPVNQRACH ILECPEGLAQ DVISTIGQAF ELRFKQYLRN PPKLVTPHDR
210 220 230 240 250
MAGFDGSAWD EEEEEPPDHQ YYNDFPGKEP PLGGVVDMRL REGAARPTLP
260
SAQMSSHLGA TL
Length:262
Mass (Da):28,759
Last modified:April 20, 2010 - v1
Checksum:i072C22B140195778
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei262 – 2621Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC171273 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000128238; ENSMUSP00000119293; ENSMUSG00000042626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC171273 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD3Z2I8.
SMRiD3Z2I8. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128238; ENSMUSP00000119293; ENSMUSG00000042626.

Organism-specific databases

MGIiMGI:98296. Shc1.

Phylogenomic databases

GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.

Miscellaneous databases

ChiTaRSiShc1. mouse.
NextBioi35550539.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z2I8.
ExpressionAtlasiD3Z2I8. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
[Graphical view]
PRINTSiPR00629. SHCPIDOMAIN.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD3Z2I8_MOUSE
AccessioniPrimary (citable) accession number: D3Z2I8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.