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Protein
Submitted name:

Citron Rho-interacting kinase

Gene

Cit

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5625900. RHO GTPases activate CIT.

Names & Taxonomyi

Protein namesi
Submitted name:
Citron Rho-interacting kinaseImported
Gene namesi
Name:CitImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:105313. Cit.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiD3Z1U0.
PaxDbiD3Z1U0.
PRIDEiD3Z1U0.

Expressioni

Gene expression databases

BgeeiD3Z1U0.
ExpressionAtlasiD3Z1U0. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiD3Z1U0. 7 interactions.
STRINGi10090.ENSMUSP00000062049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 359263Protein kinaseInterPro annotationAdd
BLAST
Domaini360 – 43071AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini1361 – 141050Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini1442 – 1562121PHInterPro annotationAdd
BLAST
Domaini1590 – 1880291CNHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili457 – 615159Sequence analysisAdd
BLAST
Coiled coili623 – 71290Sequence analysisAdd
BLAST
Coiled coili724 – 79370Sequence analysisAdd
BLAST
Coiled coili815 – 84228Sequence analysisAdd
BLAST
Coiled coili850 – 1041192Sequence analysisAdd
BLAST
Coiled coili1053 – 108028Sequence analysisAdd
BLAST
Coiled coili1092 – 116877Sequence analysisAdd
BLAST
Coiled coili1257 – 129135Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.SAAS annotation
Contains 1 PH domain.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000015347.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 6 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z1U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG
60 70 80 90 100
MLDALFALFE ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR
110 120 130 140 150
SLVGCGHFAE VQVVREKATG DVYAMKIMKK KALLAQEQVS FFEEERNILS
160 170 180 190 200
RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG DLLSLLNRYE DQLDESMIQF
210 220 230 240 250
YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF GSAAKMNSNK
260 270 280 290 300
VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT
310 320 330 340 350
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF
360 370 380 390 400
EGLCCHPFFA RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV
410 420 430 440 450
CQLSPSGFSG EELPFVGFSY SKALGYLGRS ESVVSSLDSP AKVSSMEKKL
460 470 480 490 500
LIKSKELQDS QDKCHKMEQE MTRLHRRVSE VEAVLSQKEV ELKASETQRS
510 520 530 540 550
LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD IREQSRKLQE
560 570 580 590 600
IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR
610 620 630 640 650
KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA
660 670 680 690 700
STEATELLQN IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEELEEKHR
710 720 730 740 750
EAQVSAQHLE VHLKQKEQHY EEKIKVLDNQ IKKDLADKES LENMMQRHEE
760 770 780 790 800
EAHEKGKILS EQKAMINAMD SKIRSLEQRI VELSEANKLA ANSSLFTQRN
810 820 830 840 850
MKAQEEMISE LRQQKFYLET QAGKLEAQNR KLEEQLEKIS HQDHSDKSRL
860 870 880 890 900
LELETRLREV SLEHEEQKLE LKRQLTELQL SLQERESQLT ALQAARAALE
910 920 930 940 950
SQLRQAKTEL EETTAEAEEE IQALTAHRDE IQRKFDALRN SCTVITDLEE
960 970 980 990 1000
QLNQLTEDNA ELNNQNFYLS KQLDEASGAN DEIVQLRSEV DHLRREITER
1010 1020 1030 1040 1050
EMQLTSQKQT MEALKTTCTM LEEQVLDLEA LNDELLEKER QWEAWRSVLG
1060 1070 1080 1090 1100
DEKSQFECRV RELQRMLDTE KQSRARADQR ITESRQVVEL AVKEHKAEIL
1110 1120 1130 1140 1150
ALQQALKEQK LKAESLSDKL NDLEKKHAML EMNARSLQQK LETERELKQR
1160 1170 1180 1190 1200
LLEEQAKLQQ QMDLQKNHIF RLTQGLQEAL DRADLLKTER SDLEYQLENI
1210 1220 1230 1240 1250
QVLYSHEKVK MEGTISQQTK LIDFLQAKMD QPAKKKKGLF SRRKEDPALP
1260 1270 1280 1290 1300
TQVPLQYNEL KLALEKEKAR CAELEEALQK TRIELRSARE EAAHRKATDH
1310 1320 1330 1340 1350
PHPSTPATAR QQIAMSAIVR SPEHQPSAMS LLAPPSSRRK ESSTPEEFSR
1360 1370 1380 1390 1400
RLKERMHHNI PHRFNVGLNM RATKCAVCLD TVHFGRQASK CLECQVMCHP
1410 1420 1430 1440 1450
KCSTCLPATC GLPAEYATHF TEAFCRDKMN SPGLQSKEPG SSLHLEGWMK
1460 1470 1480 1490 1500
VPRNNKRGQQ GWDRKYIVLE GSKVLIYDNE AREAGQRPVE EFELCLPDGD
1510 1520 1530 1540 1550
VSIHGAVGAS ELANTAKADV PYILKMESHP HTTCWPGRTL YLLAPSFPDK
1560 1570 1580 1590 1600
QRWVTALESV VAGGRVSREK AEADAKLLGN SLLKLEGDDR LDMNCTLPFS
1610 1620 1630 1640 1650
DQVVLVGTEE GLYALNVLKN SLTHIPGIGA VFQIYIIKDL EKLLMIAGEE
1660 1670 1680 1690 1700
RALCLVDVKK VKQSLAQSHL PAQPDVSPNI FEAVKGCHLF AAGKIENSLC
1710 1720 1730 1740 1750
ICAAMPSKVV ILRYNDNLSK YCIRKEIETS EPCSCIHFTN YSILIGTNKF
1760 1770 1780 1790 1800
YEIDMKQYTL DEFLDKNDHS LAPAVFASSS NSFPVSIVQA NSAGQREEYL
1810 1820 1830 1840 1850
LCFHEFGVFV DSYGRRSRTD DLKWSRLPLA FAYREPYLFV THFNSLEVIE
1860 1870 1880 1890 1900
IQARSSLGSP ARAYLEIPNP RYLGPAISSG AIYLASSYQD KLRVICCKGN
1910 1920 1930 1940 1950
LVKESGTEQH RVPSTSRSSP NKRGPPTYNE HITKRVASSP APPEGPSHPR
1960 1970 1980 1990 2000
EPSTPHRYRD REGRTELRRD KSPGRPLERE KSPGRMLSTR RERSPGRLFE
2010 2020
DSSRGRLPAG AVRTPLSQVN KVWDQSSV
Length:2,028
Mass (Da):231,883
Last modified:April 20, 2010 - v1
Checksum:i6EC2BC2891087DF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115795 Genomic DNA. No translation available.
AC162461 Genomic DNA. No translation available.
RefSeqiXP_006530206.1. XM_006530143.2.
UniGeneiMm.426282.
Mm.8321.

Genome annotation databases

EnsembliENSMUST00000112008; ENSMUSP00000107639; ENSMUSG00000029516.
GeneIDi12704.
UCSCiuc008zeu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115795 Genomic DNA. No translation available.
AC162461 Genomic DNA. No translation available.
RefSeqiXP_006530206.1. XM_006530143.2.
UniGeneiMm.426282.
Mm.8321.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3Z1U0. 7 interactions.
STRINGi10090.ENSMUSP00000062049.

Proteomic databases

MaxQBiD3Z1U0.
PaxDbiD3Z1U0.
PRIDEiD3Z1U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112008; ENSMUSP00000107639; ENSMUSG00000029516.
GeneIDi12704.
UCSCiuc008zeu.1. mouse.

Organism-specific databases

CTDi11113.
MGIiMGI:105313. Cit.

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000015347.

Enzyme and pathway databases

ReactomeiR-MMU-5625900. RHO GTPases activate CIT.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiD3Z1U0.
ExpressionAtlasiD3Z1U0. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 6 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z1U0_MOUSE
AccessioniPrimary (citable) accession number: D3Z1U0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.