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Protein

Elongation of very long chain fatty acids protein

Gene

Elovl5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids proteinUniRule annotation (EC:2.3.1.199UniRule annotation)
Alternative name(s):
Very-long-chain 3-oxoacyl-CoA synthaseUniRule annotation
Gene namesi
Name:Elovl5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916051 Elovl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 49HelicalUniRule annotationAdd BLAST18
Transmembranei61 – 81HelicalUniRule annotationAdd BLAST21
Transmembranei114 – 132HelicalUniRule annotationAdd BLAST19
Transmembranei153 – 176HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiD3Z136
PeptideAtlasiD3Z136
PRIDEiD3Z136

Expressioni

Gene expression databases

BgeeiENSMUSG00000032349
ExpressionAtlasiD3Z136 baseline and differential

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3071 Eukaryota
ENOG410XRWT LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038120

Family and domain databases

InterProiView protein in InterPro
IPR002076 ELO_fam
IPR033677 ELOVL5
PANTHERiPTHR11157 PTHR11157, 1 hit
PTHR11157:SF18 PTHR11157:SF18, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit

Sequencei

Sequence statusi: Fragment.

D3Z136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHFDASLST YFKAFLGPRD TRVKGWFLLD NYIPTFVCSV IYLLIVWLGP
60 70 80 90 100
KYMKNRQPFS CRGILQLYNL GLTLLSLYMF YELVTGVWEG KYNFFCQGTR
110 120 130 140 150
SAGESDMKII RVLWWYYFSK LIEFMDTFFF ILRKNNHQIT VLHVYHHATM
160 170 180
LNIWWFVMNW VPCGHSYFGA TLNSFIHVLM
Length:180
Mass (Da):21,543
Last modified:April 20, 2010 - v1
Checksum:i38D9289152A2B4C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei180Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159886 Genomic DNA No translation available.
AC160334 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000133757; ENSMUSP00000123121; ENSMUSG00000032349

Similar proteinsi

Entry informationi

Entry nameiD3Z136_MOUSE
AccessioniPrimary (citable) accession number: D3Z136
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health