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Protein

Elongation of very long chain fatty acids protein

Gene

Elovl5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

GO - Molecular functioni

  1. fatty acid elongase activity Source: MGI

GO - Biological processi

  1. fatty acid elongation, monounsaturated fatty acid Source: MGI
  2. fatty acid elongation, polyunsaturated fatty acid Source: MGI
  3. very long-chain fatty acid biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids proteinUniRule annotation (EC:2.3.1.199UniRule annotation)
Alternative name(s):
Very-long-chain 3-oxoacyl-CoA synthaseUniRule annotation
Gene namesi
Name:Elovl5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1916051. Elovl5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 4918HelicalUniRule annotationAdd
BLAST
Transmembranei61 – 8121HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13219HelicalUniRule annotationAdd
BLAST
Transmembranei153 – 17624HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. dendritic tree Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
  5. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiD3Z136.
ExpressionAtlasiD3Z136. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119122.
HOGENOMiHOG000038120.

Family and domain databases

InterProiIPR002076. GNS1_SUR4.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3Z136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHFDASLST YFKAFLGPRD TRVKGWFLLD NYIPTFVCSV IYLLIVWLGP
60 70 80 90 100
KYMKNRQPFS CRGILQLYNL GLTLLSLYMF YELVTGVWEG KYNFFCQGTR
110 120 130 140 150
SAGESDMKII RVLWWYYFSK LIEFMDTFFF ILRKNNHQIT VLHVYHHATM
160 170 180
LNIWWFVMNW VPCGHSYFGA TLNSFIHVLM
Length:180
Mass (Da):21,543
Last modified:April 20, 2010 - v1
Checksum:i38D9289152A2B4C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei180 – 1801Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159886 Genomic DNA. No translation available.
AC160334 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000133757; ENSMUSP00000123121; ENSMUSG00000032349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159886 Genomic DNA. No translation available.
AC160334 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133757; ENSMUSP00000123121; ENSMUSG00000032349.

Organism-specific databases

MGIiMGI:1916051. Elovl5.

Phylogenomic databases

GeneTreeiENSGT00760000119122.
HOGENOMiHOG000038120.

Miscellaneous databases

ChiTaRSiElovl5. mouse.
NextBioi35550194.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z136.
ExpressionAtlasiD3Z136. baseline and differential.

Family and domain databases

InterProiIPR002076. GNS1_SUR4.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z136_MOUSE
AccessioniPrimary (citable) accession number: D3Z136
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.