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Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. sodium:proton antiporter activity Source: InterPro

GO - Biological processi

  1. axon extension Source: MGI
  2. brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  3. dendrite extension Source: MGI
  4. dendritic spine development Source: MGI
  5. neuron projection morphogenesis Source: MGI
  6. proton transport Source: MGI
  7. regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  8. regulation of pH Source: InterPro
  9. synapse organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotation, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_324002. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Subcellular locationi

GO - Cellular componenti

  1. axonal spine Source: MGI
  2. axon terminus Source: MGI
  3. cytoplasmic vesicle Source: MGI
  4. dendrite Source: MGI
  5. early endosome Source: MGI
  6. early endosome membrane Source: MGI
  7. endoplasmic reticulum membrane Source: MGI
  8. endosome Source: MGI
  9. integral component of membrane Source: UniProtKB-KW
  10. intracellular membrane-bounded organelle Source: MGI
  11. late endosome Source: MGI
  12. mitochondrion Source: MGI
  13. plasma membrane Source: MGI
  14. recycling endosome Source: MGI
  15. recycling endosome membrane Source: MGI
  16. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiD3Z0Q9.

Expressioni

Gene expression databases

BgeeiD3Z0Q9.
ExpressionAtlasiD3Z0Q9. baseline and differential.

Structurei

3D structure databases

SMRiD3Z0Q9. Positions 198-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.

Sequencei

Sequence statusi: Fragment.

D3Z0Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEIVSEKQ AEESHRQDSA NLLIFILLLT LTILTIWLFK HRRARFLHET
60 70 80 90 100
GLAMIYGLLV GLVLRYGIHV PSDVNNVTLS CEVQSSPTTL LVNVSGKFYE
110 120 130 140 150
YTLKGEISSH ELNNVQDNEM LRKVTFDPEV FFNILLPPII FYAGYSLKRR
160 170 180 190 200
HFFRNLGSIL AYAFLGTAIS CFVIGSIMYG CVTLMKVTGQ LAGDFYFTDC
210 220 230 240 250
LLFGAIVSAT DPVTVLAIFH ELQVDVELYA LLFGESVLND AVAIVLSSSI
260 270 280 290
VAYQPAGDNS HTFDVTAMFK SIGIFLGIFS GSFAMGAATG V
Length:291
Mass (Da):32,126
Last modified:April 19, 2010 - v1
Checksum:i930DB38FF3BFB2B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei291 – 2911Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000144068; ENSMUSP00000115364; ENSMUSG00000060681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.

3D structure databases

SMRiD3Z0Q9. Positions 198-226.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD3Z0Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000144068; ENSMUSP00000115364; ENSMUSG00000060681.

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Phylogenomic databases

GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.

Enzyme and pathway databases

ReactomeiREACT_324002. Sodium/Proton exchangers.

Miscellaneous databases

NextBioi35550095.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z0Q9.
ExpressionAtlasiD3Z0Q9. baseline and differential.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z0Q9_MOUSE
AccessioniPrimary (citable) accession number: D3Z0Q9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 19, 2010
Last sequence update: April 19, 2010
Last modified: March 31, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.