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Protein
Submitted name:

Protein Slc9a6

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axon extension Source: MGI
  • brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  • dendrite extension Source: MGI
  • dendritic spine development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • proton transport Source: MGI
  • regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • regulation of pH Source: InterPro
  • synapse organization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Slc9a6Imported
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20
Transmembranei51 – 68HelicalSequence analysisAdd BLAST18
Transmembranei130 – 147HelicalSequence analysisAdd BLAST18
Transmembranei159 – 180HelicalSequence analysisAdd BLAST22
Transmembranei195 – 219HelicalSequence analysisAdd BLAST25
Transmembranei231 – 252HelicalSequence analysisAdd BLAST22
Transmembranei272 – 296HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

  • axonal spine Source: MGI
  • axon terminus Source: MGI
  • cytoplasmic vesicle Source: MGI
  • dendrite Source: MGI
  • early endosome Source: MGI
  • early endosome membrane Source: MGI
  • endoplasmic reticulum membrane Source: MGI
  • endosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: MGI
  • late endosome Source: MGI
  • mitochondrion Source: MGI
  • plasma membrane Source: MGI
  • recycling endosome Source: MGI
  • recycling endosome membrane Source: MGI
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiD3Z0Q9.
PeptideAtlasiD3Z0Q9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060681.
ExpressionAtlasiD3Z0Q9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076922.

Structurei

3D structure databases

SMRiD3Z0Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 310Na_H_ExchangerInterPro annotationAdd BLAST285

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 2 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.

Sequencei

Sequence statusi: Fragment.

D3Z0Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEIVSEKQ AEESHRQDSA NLLIFILLLT LTILTIWLFK HRRARFLHET
60 70 80 90 100
GLAMIYGLLV GLVLRYGIHV PSDVNNVTLS CEVQSSPTTL LVNVSGKFYE
110 120 130 140 150
YTLKGEISSH ELNNVQDNEM LRKVTFDPEV FFNILLPPII FYAGYSLKRR
160 170 180 190 200
HFFRNLGSIL AYAFLGTAIS CFVIGSIMYG CVTLMKVTGQ LAGDFYFTDC
210 220 230 240 250
LLFGAIVSAT DPVTVLAIFH ELQVDVELYA LLFGESVLND AVAIVLSSSI
260 270 280 290 300
VAYQPAGDNS HTFDVTAMFK SIGIFLGIFS GSFAMGAATG VVTALVTKFT
310
KLREFQLLET GLF
Length:313
Mass (Da):34,663
Last modified:October 14, 2015 - v2
Checksum:iC8EF3D5846253181
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei313Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000144068; ENSMUSP00000115364; ENSMUSG00000060681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.

3D structure databases

SMRiD3Z0Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076922.

Proteomic databases

PaxDbiD3Z0Q9.
PeptideAtlasiD3Z0Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000144068; ENSMUSP00000115364; ENSMUSG00000060681.

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060681.
ExpressionAtlasiD3Z0Q9. baseline and differential.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 2 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
ProtoNetiSearch...

Entry informationi

Entry nameiD3Z0Q9_MOUSE
AccessioniPrimary (citable) accession number: D3Z0Q9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: October 14, 2015
Last modified: November 30, 2016
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.