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Protein
Submitted name:

Solute carrier family 9 (sodium/hydrogen exchanger), member 6

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axon extension Source: MGI
  • brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  • dendrite extension Source: MGI
  • dendritic spine development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • regulation of pH Source: InterPro
  • synapse organization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-425986 Sodium/Proton exchangers

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 9 (sodium/hydrogen exchanger), member 6Imported
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2443511 Slc9a6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20
Transmembranei51 – 68HelicalSequence analysisAdd BLAST18
Transmembranei130 – 147HelicalSequence analysisAdd BLAST18
Transmembranei159 – 180HelicalSequence analysisAdd BLAST22
Transmembranei195 – 219HelicalSequence analysisAdd BLAST25
Transmembranei231 – 252HelicalSequence analysisAdd BLAST22
Transmembranei272 – 296HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiD3Z0Q9

Expressioni

Gene expression databases

BgeeiENSMUSG00000060681
ExpressionAtlasiD3Z0Q9 baseline and differential

Structurei

3D structure databases

SMRiD3Z0Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 310Na_H_ExchangerInterPro annotationAdd BLAST285

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000172307

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR002090 Na/H_exchanger_6
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01088 NAHEXCHNGR6

Sequencei

Sequence statusi: Fragment.

D3Z0Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEIVSEKQ AEESHRQDSA NLLIFILLLT LTILTIWLFK HRRARFLHET
60 70 80 90 100
GLAMIYGLLV GLVLRYGIHV PSDVNNVTLS CEVQSSPTTL LVNVSGKFYE
110 120 130 140 150
YTLKGEISSH ELNNVQDNEM LRKVTFDPEV FFNILLPPII FYAGYSLKRR
160 170 180 190 200
HFFRNLGSIL AYAFLGTAIS CFVIGSIMYG CVTLMKVTGQ LAGDFYFTDC
210 220 230 240 250
LLFGAIVSAT DPVTVLAIFH ELQVDVELYA LLFGESVLND AVAIVLSSSI
260 270 280 290 300
VAYQPAGDNS HTFDVTAMFK SIGIFLGIFS GSFAMGAATG VVTALVTKFT
310
KLREFQLLET GLF
Length:313
Mass (Da):34,663
Last modified:October 14, 2015 - v2
Checksum:iC8EF3D5846253181
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei313Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA No translation available.
AL672085 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000144068; ENSMUSP00000115364; ENSMUSG00000060681

Similar proteinsi

Entry informationi

Entry nameiD3Z0Q9_MOUSE
AccessioniPrimary (citable) accession number: D3Z0Q9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: October 14, 2015
Last modified: April 25, 2018
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health