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Protein
Submitted name:

MCG18410, isoform CRA_a

Gene

Ddx23

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. poly(A) RNA binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotation, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_271571. mRNA Splicing - Minor Pathway.
REACT_307866. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
MCG18410, isoform CRA_aImported
Submitted name:
Protein Ddx23Imported
Gene namesi
Name:Ddx23Imported
ORF Names:mCG_18410Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1921601. Ddx23.

Subcellular locationi

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. mitochondrion Source: MGI
  4. nucleolus Source: MGI
  5. nucleoplasm Source: MGI
  6. nucleus Source: MGI
  7. plasma membrane Source: MGI
  8. U4/U6 x U5 tri-snRNP complex Source: MGI
  9. U5 snRNP Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiD3Z0M9.
PRIDEiD3Z0M9.

Expressioni

Gene expression databases

BgeeiD3Z0M9.
ExpressionAtlasiD3Z0M9. baseline.

Structurei

3D structure databases

ProteinModelPortaliD3Z0M9.
SMRiD3Z0M9. Positions 351-805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00780000121930.
HOGENOMiHOG000268796.
InParanoidiD3Z0M9.
KOiK12858.
OMAiNPIYKEK.
OrthoDBiEOG7XH6P9.
PhylomeDBiD3Z0M9.
TreeFamiTF300527.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z0M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGELADKKD RDASPKEERK RSRTPERDRD RDRDRKSSPS KDRKRHRSRD
60 70 80 90 100
RRRGGSRSRS RSRSKSVERE RRHKERERDK ERDRSKKERE RDKDGHRRDK
110 120 130 140 150
DRKRSSLSPG RGKDFKSRKD RDSKKGDEDE HGDKRPKIQP LSLEELLAKK
160 170 180 190 200
KAEEEAEAKP KFLSKAEREA EALKRRQQEV EERQKMLEEE RKKRKQFQDL
210 220 230 240 250
GRKMLEDPQE RERRERRERM ERETNGNEDE EGRQKIREEK DKSKELHAIK
260 270 280 290 300
ERYLGGIKKR RRTRHLNDRK FVFEWDASED TSIDYNPLYK ERHQVQLLGR
310 320 330 340 350
GFIAGIDLKQ QKREQSRFYG DLMEKRRTLE EKEQEEARLR KLRKKEAKQR
360 370 380 390 400
WDDRHWSQKK LDEMTDRDWR IFREDYSITT KGGKIPNPIR SWKDSSLPPH
410 420 430 440 450
ILEVIDKCGY KEPTPIQRQA IPIGLQNRDI IGVAETGSGK TAAFLIPLLV
460 470 480 490 500
WITTLPKIDR IEESDQGPYA IILAPTRELA QQIEEETIKF GKPLGIRTVA
510 520 530 540 550
VIGGISREDQ GFRLRMGCEI VIATPGRLID VLENRYLVLS RCTYVVLDEA
560 570 580 590 600
DRMIDMGFEP DVQKILEHMP VSNQKPDTDE AEDPEKMLAN FESGKHKYRQ
610 620 630 640 650
TVMFTATMPP AVERLARSYL RRPAVVYIGS AGKPHERVEQ KVFLMSESEK
660 670 680 690 700
RKKLLAILEQ GFDPPIIIFV NQKKGCDVLA KSLEKMGYNA CTLHGGKGQE
710 720 730 740 750
QREFALSNLK AGAKDILVAT DVAGRGIDIQ DVSMVVNYDM AKNIEDYIHR
760 770 780 790 800
IGRTGRAGKS GVAITFLTKE DSAVFYELKQ AILESPVSSC PPELANHPDA
810
QHKPGTILTK KRREETIFA
Length:819
Mass (Da):95,495
Last modified:April 20, 2010 - v1
Checksum:i55D2738CEE657639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156543 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04176.1.
RefSeqiNP_001074450.1. NM_001080981.1.
XP_006521556.1. XM_006521493.2.
UniGeneiMm.45725.

Genome annotation databases

EnsembliENSMUST00000003450; ENSMUSP00000003450; ENSMUSG00000003360.
GeneIDi74351.
KEGGimmu:74351.
UCSCiuc007xne.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156543 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04176.1.
RefSeqiNP_001074450.1. NM_001080981.1.
XP_006521556.1. XM_006521493.2.
UniGeneiMm.45725.

3D structure databases

ProteinModelPortaliD3Z0M9.
SMRiD3Z0M9. Positions 351-805.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD3Z0M9.
PRIDEiD3Z0M9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003450; ENSMUSP00000003450; ENSMUSG00000003360.
GeneIDi74351.
KEGGimmu:74351.
UCSCiuc007xne.1. mouse.

Organism-specific databases

CTDi9416.
MGIiMGI:1921601. Ddx23.

Phylogenomic databases

GeneTreeiENSGT00780000121930.
HOGENOMiHOG000268796.
InParanoidiD3Z0M9.
KOiK12858.
OMAiNPIYKEK.
OrthoDBiEOG7XH6P9.
PhylomeDBiD3Z0M9.
TreeFamiTF300527.

Enzyme and pathway databases

ReactomeiREACT_271571. mRNA Splicing - Minor Pathway.
REACT_307866. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiDdx23. mouse.
NextBioi340513.
PROiD3Z0M9.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z0M9.
ExpressionAtlasiD3Z0M9. baseline.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z0M9_MOUSE
AccessioniPrimary (citable) accession number: D3Z0M9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.