ID   D3Z079_MOUSE            Unreviewed;      1116 AA.
AC   D3Z079;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   SubName: Full=Syntaxin binding protein 5 (tomosyn) {ECO:0000313|Ensembl:ENSMUSP00000123253.2};
GN   Name=Stxbp5 {ECO:0000313|Ensembl:ENSMUSP00000123253.2,
GN   ECO:0000313|MGI:MGI:1926058};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123253.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:16452087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [2] {ECO:0007829|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [3] {ECO:0007829|PubMed:19144319}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000123253.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123253.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000123253.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123253.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the WD repeat L(2)GL family.
CC       {ECO:0000256|ARBA:ARBA00008070}.
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DR   RefSeq; NP_001074813.2; NM_001081344.2.
DR   AlphaFoldDB; D3Z079; -.
DR   SMR; D3Z079; -.
DR   jPOST; D3Z079; -.
DR   MaxQB; D3Z079; -.
DR   PeptideAtlas; D3Z079; -.
DR   ProteomicsDB; 361783; -.
DR   Antibodypedia; 33249; 72 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000141722.8; ENSMUSP00000123253.2; ENSMUSG00000019790.18.
DR   GeneID; 78808; -.
DR   KEGG; mmu:78808; -.
DR   UCSC; uc007eiz.2; mouse.
DR   AGR; MGI:1926058; -.
DR   CTD; 134957; -.
DR   MGI; MGI:1926058; Stxbp5.
DR   VEuPathDB; HostDB:ENSMUSG00000019790; -.
DR   GeneTree; ENSGT00950000182906; -.
DR   OMA; IVWKFFD; -.
DR   OrthoDB; 415950at2759; -.
DR   TreeFam; TF314585; -.
DR   BioGRID-ORCS; 78808; 1 hit in 78 CRISPR screens.
DR   ChiTaRS; Stxbp5; mouse.
DR   Proteomes; UP000000589; Chromosome 10.
DR   Bgee; ENSMUSG00000019790; Expressed in animal zygote and 220 other cell types or tissues.
DR   ExpressionAtlas; D3Z079; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   CDD; cd15893; R-SNARE_STXBP5; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR000664; Lethal2_giant.
DR   InterPro; IPR013905; Lgl_C_dom.
DR   InterPro; IPR013577; LLGL2.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR10241; LETHAL 2 GIANT LARVAE PROTEIN; 1.
DR   PANTHER; PTHR10241:SF22; SYNTAXIN-BINDING PROTEIN 5; 1.
DR   Pfam; PF08596; Lgl_C; 1.
DR   Pfam; PF08366; LLGL; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PRINTS; PR00962; LETHAL2GIANT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF58038; SNARE fusion complex; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50892; V_SNARE; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   Genevisible; D3Z079; MM.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Proteomics identification {ECO:0007829|EPD:D3Z079,
KW   ECO:0007829|MaxQB:D3Z079};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          234..269
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          1051..1111
FT                   /note="V-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50892"
FT   REGION          14..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          675..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..871
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..582
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..739
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        847..863
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1116 AA;  123602 MW;  AB8E0C8C41693427 CRC64;
     MRKFNIRKVL DGLTAGSSSA SQQQQQQQHP PGNREPEIQE TLQSEHFQLC KTVRHGFPYQ
     PSALAFDPVQ KILAVGTQTG ALRLFGRPGV ECYCQHDSGA AVIQLQFLIN EGALVSALAD
     DTLHLWNLRQ KRPAVLHSLK FCRERVTFCH LPFQSKWLYV GTERGNIHIV NVESFTLSGY
     VIMWNKAIEL SSKAHPGPVV HISDNPMDEG KLLIGFESGT VVLWDLKSKK ADYRYTYDEA
     IHSVAWHHEG KQFICSHSDG TLTIWNVRSP AKPVQTITPH GKQLKDGKKP EPCKPILKVE
     LKTTRSGEPF IILSGGLSYD TVGRRPCLTV MHGKSTAVLE MDYSIVDFLT LCETPYPNDF
     QEPYAVVVLL EKDLVLIDLA QNGYPIFENP YPLSIHESPV TCCEYFADCP VDLIPALYSV
     GARQKRQGYS KKEWPINGGN WGLGAQSYPE IIITGHADGS VKFWDASAIT LQVLYKLKTS
     KVFEKSRNKD DRQNTDIVDE DPYAIQIISW CPESRMLCIA GVSAHVIIYR FSKQEVLTEV
     IPMLEVRLLY EINDVDTPEG EQPPPLSTPV GSSNPQPIPP QSHPSTSSSS SDGLRDNVPC
     LKVKNSPLKQ SPGYQTELVI QLVWVGGEPP QQITSLALNS SYGLVVFGNC NGIAMVDYLQ
     KAVLLNLSTI ELYGSNDPYR REPRSPRKSR QPSGAGLCDI TEGTVVPEDR CKSPTSAKMS
     RKLSLPTDLK PDLDVKDNSF SRSRSSSVTS IDKESRETIS ALHFCETLTR KADSSPSPCL
     WVGTTVGTAF VITLNLPPGP EQRLLQPVIV SPSGTILRLK GAILRMAFLD ATGCLMSPAY
     EPWKEHNVAE EKDEKEKLKK RRPVSVSPSS SQEISENQYA VICSEKQAKV MSLPTQSCAY
     KQNITETSFV LRGDIVALSN SVCLACFCAN GHIMTFSLPS LRPLLDVYYL PLTNMRIART
     FCFANNGQAL YLVSPTEIQR LTYSQETCEN LQEMLGELFT PVETPEAPNR GFFKGLFGGG
     AQSLDREELF GESSSGKASR SLAQHIPGPG GIEGVKGAAS GVVGELARAR LALDERGQKL
     SDLEERTAAM MSSADSFSKH AHEMMLKYKD KKWYQF
//