Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 and multiple ankyrin repeat domains protein 1Imported
Gene namesi
Name:Shank1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3613677 Shank1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiD3YZU4
PeptideAtlasiD3YZU4
PRIDEiD3YZU4

Expressioni

Gene expression databases

BgeeiENSMUSG00000038738
ExpressionAtlasiD3YZU4 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiD3YZU4, 2 interactors
MINTiD3YZU4

Structurei

3D structure databases

ProteinModelPortaliD3YZU4
SMRiD3YZU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 399ANK_REP_REGIONInterPro annotationAdd BLAST222
Repeati246 – 278ANKPROSITE-ProRule annotationAdd BLAST33
Repeati313 – 345ANKPROSITE-ProRule annotationAdd BLAST33
Repeati346 – 378ANKPROSITE-ProRule annotationAdd BLAST33
Domaini554 – 613SH3InterPro annotationAdd BLAST60
Domaini663 – 757PDZInterPro annotationAdd BLAST95
Domaini2096 – 2159SAMInterPro annotationAdd BLAST64

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00510000046474
HOGENOMiHOG000293276

Family and domain databases

CDDicd00204 ANK, 2 hits
cd11982 SH3_Shank1, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032425 FERM_f0
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035735 Shank1_SH3
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16511 FERM_f0, 1 hit
PF00595 PDZ, 1 hit
PF00536 SAM_1, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

D3YZU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN
60 70 80 90 100
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGASSSG TPGPTSGSQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG
660 670 680 690 700
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMEYEQ
810 820 830 840 850
QPAAVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH
860 870 880 890 900
RPKGFFATES SFDPHHRSQP SYDRPSFLPP GPGLMLRQKS IGAAEDDRPY
910 920 930 940 950
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPAPS SSGRLTPSPR
960 970 980 990 1000
GGPFNPGSGG PLPASSPSSF DGPSPPDPRS GGREKSLYHS GALPPAHHHP
1010 1020 1030 1040 1050
PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW
1060 1070 1080 1090 1100
RGGGPSPTSG APSPSHHSSS GGSSGPAQAP ALRYFQLPPR AASAAMYVPA
1110 1120 1130 1140 1150
RSGRGRKGPL VKQTKVEGEP QKGSLPPASS PTSPALPRSE PPPAGPSEKN
1160 1170 1180 1190 1200
SIPIPTIIIK APSTSSSGRS SQGSSTEAEP PTQPDGAGGG GSSPSPAPAT
1210 1220 1230 1240 1250
SPVPPSPSPV PTPASPSGPA TLDFTSQFGA ALVGAARREG GWQNEARRRS
1260 1270 1280 1290 1300
TLFLSTDAGD EDGGDSGLGP GAPPGPRLRH SKSIDEGMFS AEPYLRLESG
1310 1320 1330 1340 1350
GSSGGYGAYA AGSRAYGGSG SSSAFTSFLP PRPLVHPLTG KALDPASPLG
1360 1370 1380 1390 1400
LALAARERAL KESSEGGVTP QPPPRPPSPR YDAPPPTLHH HSPHSPHSPH
1410 1420 1430 1440 1450
ARHEPVLRLW GDPARRELGY RAGLGSQEKA LTASPPAARR SLLHRLPPTA
1460 1470 1480 1490 1500
PGVGPLLLQL GPEPPTPHPG VSKAWRTAAP EEPERLPLHV RFLENCQARP
1510 1520 1530 1540 1550
PPAGTRGSST EDGPGVPPPS PRRVLPTSPT SPRGNEENGL PLLVLPPPAP
1560 1570 1580 1590 1600
SVDVDDGEFL FAEPLPPPLE FSNSFEKPES PLTPGPPHPL PDPPSPATPL
1610 1620 1630 1640 1650
PAAPPPAVAA APPTLDSTAS SLTSYDSEVA TLTQGAPAAP GDPPAPGPPA
1660 1670 1680 1690 1700
PAAPAPPAPQ PGPDPPPGTD SGIEEVDSRS SSDHPLETIS SASTLSSLSA
1710 1720 1730 1740 1750
EGGGNTGGVA GGGAGVASGT ELLDTYVAYL DGQAFGGSGT PGPPYPPQLM
1760 1770 1780 1790 1800
TPSKLRGRAL GTSGNLRPGP SGGLRDPVTP TSPTVSVTGA GTDGLLALSA
1810 1820 1830 1840 1850
CSGPSTAGVA GGPVAVEPEV PPVPLPTASS LPRKLLPWEE GPGPPPPPLP
1860 1870 1880 1890 1900
GPLSQPQASA LATVKASIIS ELSSKLQQFG GASTAGGALP WARGGSGGST
1910 1920 1930 1940 1950
DSHHGGASYI PERTSSLQRQ RLSEDSQTSL LSKPSSSIFQ NWPKPPLPPL
1960 1970 1980 1990 2000
PTGSGVSSST AAAPGATSPS ASSASASTRH LQGVEFEMRP PLLRRAPSPS
2010 2020 2030 2040 2050
LLPASDHKVS PAPRPSSLPI LPSGPLYPGL FDIRSSPTGG AGGSADPFAP
2060 2070 2080 2090 2100
VFVPPHPGIS GGLGGALSGA SRSLSPTRLL SLPPDKPFGA KPLGFWTKFD
2110 2120 2130 2140 2150
VADWLEWLGL SEHRAQFLDH EIDGSHLPAL TKEDYVDLGV TRVGHRMNID

RALKFFLER
Length:2,159
Mass (Da):225,350
Last modified:April 20, 2010 - v1
Checksum:i78EA8FD9E436C06F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152939 Genomic DNA No translation available.
RefSeqiXP_006540928.1, XM_006540865.3
UniGeneiMm.360368

Genome annotation databases

EnsembliENSMUST00000107935; ENSMUSP00000103568; ENSMUSG00000038738
GeneIDi243961

Similar proteinsi

Entry informationi

Entry nameiD3YZU4_MOUSE
AccessioniPrimary (citable) accession number: D3YZU4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health