D3YZU4 (D3YZU4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
SH3 and multiple ankyrin repeat domains protein 1 Ensembl ENSMUSP00000103568

Gene names

Name:

Shank1 Ensembl ENSMUSP00000103568 MGI 3613677

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000103568

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2159 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 PDZ (DHR) domain. RuleBase RU003354 Contains 1 SH3 domain. SAAS SAAS011511
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000103568

Ontologies

Keywords
Domain	ANK repeat RuleBase RU003321 SAAS SAAS013761 Repeat SAAS SAAS013761 RuleBase RU003536
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of actin filament bundle assembly Inferred from direct assay PubMed 19208628. Source: MGI
Cellular_component	postsynaptic membrane Inferred from direct assay PubMed 15950311. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3YZU4 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: 78EA8FD9E436C06F	FASTA	2,159	225,350
	10 20 30 40 50 60 MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN LASTRGLQGR 70 80 90 100 110 120 SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK QQVLCALSES LQDVLNYGLF 130 140 150 160 170 180 QPATSGRDAN FLEEERLLRE YPQSFEKGVP YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL 190 200 210 220 230 240 KKFLEYVQLG TSDKVARLLD KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI 250 260 270 280 290 300 DFRARDGMTA LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 310 320 330 340 350 360 LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA LHICALYNKE 370 380 390 400 410 420 TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR NHREQDVVPF QESPKYAARR 430 440 450 460 470 480 RGPPGAGLTV PPALLRANSD TSMALPDWMV FSAPGASSSG TPGPTSGSQG QSQPSAPSTK 490 500 510 520 530 540 LSSGTLRSAS SPRGARARSP SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS 550 560 570 580 590 600 LGSRGRRRKL YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 610 620 630 640 650 660 GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG IDSGSDYIIK 670 680 690 700 710 720 EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ YLESVDEGGV AWRAGLRMGD 730 740 750 760 770 780 FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP 790 800 810 820 830 840 AISLRSKSMT SELEEMEYEQ QPAAVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG 850 860 870 880 890 900 PGGLASLGKH RPKGFFATES SFDPHHRSQP SYDRPSFLPP GPGLMLRQKS IGAAEDDRPY 910 920 930 940 950 960 LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPAPS SSGRLTPSPR GGPFNPGSGG 970 980 990 1000 1010 1020 PLPASSPSSF DGPSPPDPRS GGREKSLYHS GALPPAHHHP PHHHHHHAPP PQPHHHHAHP 1030 1040 1050 1060 1070 1080 PHPPEMETGG SPDDPPPRLA LGPQPSLRGW RGGGPSPTSG APSPSHHSSS GGSSGPAQAP 1090 1100 1110 1120 1130 1140 ALRYFQLPPR AASAAMYVPA RSGRGRKGPL VKQTKVEGEP QKGSLPPASS PTSPALPRSE 1150 1160 1170 1180 1190 1200 PPPAGPSEKN SIPIPTIIIK APSTSSSGRS SQGSSTEAEP PTQPDGAGGG GSSPSPAPAT 1210 1220 1230 1240 1250 1260 SPVPPSPSPV PTPASPSGPA TLDFTSQFGA ALVGAARREG GWQNEARRRS TLFLSTDAGD 1270 1280 1290 1300 1310 1320 EDGGDSGLGP GAPPGPRLRH SKSIDEGMFS AEPYLRLESG GSSGGYGAYA AGSRAYGGSG 1330 1340 1350 1360 1370 1380 SSSAFTSFLP PRPLVHPLTG KALDPASPLG LALAARERAL KESSEGGVTP QPPPRPPSPR 1390 1400 1410 1420 1430 1440 YDAPPPTLHH HSPHSPHSPH ARHEPVLRLW GDPARRELGY RAGLGSQEKA LTASPPAARR 1450 1460 1470 1480 1490 1500 SLLHRLPPTA PGVGPLLLQL GPEPPTPHPG VSKAWRTAAP EEPERLPLHV RFLENCQARP 1510 1520 1530 1540 1550 1560 PPAGTRGSST EDGPGVPPPS PRRVLPTSPT SPRGNEENGL PLLVLPPPAP SVDVDDGEFL 1570 1580 1590 1600 1610 1620 FAEPLPPPLE FSNSFEKPES PLTPGPPHPL PDPPSPATPL PAAPPPAVAA APPTLDSTAS 1630 1640 1650 1660 1670 1680 SLTSYDSEVA TLTQGAPAAP GDPPAPGPPA PAAPAPPAPQ PGPDPPPGTD SGIEEVDSRS 1690 1700 1710 1720 1730 1740 SSDHPLETIS SASTLSSLSA EGGGNTGGVA GGGAGVASGT ELLDTYVAYL DGQAFGGSGT 1750 1760 1770 1780 1790 1800 PGPPYPPQLM TPSKLRGRAL GTSGNLRPGP SGGLRDPVTP TSPTVSVTGA GTDGLLALSA 1810 1820 1830 1840 1850 1860 CSGPSTAGVA GGPVAVEPEV PPVPLPTASS LPRKLLPWEE GPGPPPPPLP GPLSQPQASA 1870 1880 1890 1900 1910 1920 LATVKASIIS ELSSKLQQFG GASTAGGALP WARGGSGGST DSHHGGASYI PERTSSLQRQ 1930 1940 1950 1960 1970 1980 RLSEDSQTSL LSKPSSSIFQ NWPKPPLPPL PTGSGVSSST AAAPGATSPS ASSASASTRH 1990 2000 2010 2020 2030 2040 LQGVEFEMRP PLLRRAPSPS LLPASDHKVS PAPRPSSLPI LPSGPLYPGL FDIRSSPTGG 2050 2060 2070 2080 2090 2100 AGGSADPFAP VFVPPHPGIS GGLGGALSGA SRSLSPTRLL SLPPDKPFGA KPLGFWTKFD 2110 2120 2130 2140 2150 VADWLEWLGL SEHRAQFLDH EIDGSHLPAL TKEDYVDLGV TRVGHRMNID RALKFFLER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000103568.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000103568.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC152939 Genomic DNA. No translation available.
IPI	IPI00758339.
3D structure databases
ProteinModelPortal	D3YZU4.
SMR	D3YZU4. Positions 656-759, 2093-2154.
ModBase	Search...
Proteomic databases
PRIDE	D3YZU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000107935; ENSMUSP00000103568; ENSMUSG00000038738.
Organism-specific databases
MGI	MGI:3613677. Shank1.
Phylogenomic databases
GeneTree	ENSGT00510000046474.
HOGENOM	HOG000293276.
Gene expression databases
ArrayExpress	D3YZU4.
Bgee	D3YZU4.
Family and domain databases
Gene3D	1.10.150.50. 1 hit. 1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001478. PDZ. IPR001660. SAM. IPR013761. SAM/pointed. IPR021129. SAM_type1. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. PF00595. PDZ. 1 hit. PF00536. SAM_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 6 hits. SM00228. PDZ. 1 hit. SM00454. SAM. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF50156. PDZ. 1 hit. SSF47769. SAM_homology. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. PS50106. PDZ. 1 hit. PS50105. SAM_DOMAIN. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35549888.
SOURCE	Search...

Entry information

Entry name

D3YZU4_MOUSE

Accession

Primary (citable) accession number: D3YZU4

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)