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D3YZU4

- D3YZU4_MOUSE

UniProt

D3YZU4 - D3YZU4_MOUSE

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Protein
Submitted name:

SH3 and multiple ankyrin repeat domains protein 1

Gene
Shank1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. negative regulation of actin filament bundle assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 and multiple ankyrin repeat domains protein 1Imported
Gene namesi
Name:Shank1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:3613677. Shank1.

Subcellular locationi

GO - Cellular componenti

  1. postsynaptic membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3YZU4.

Expressioni

Gene expression databases

ArrayExpressiD3YZU4.
BgeeiD3YZU4.

Interactioni

Protein-protein interaction databases

IntActiD3YZU4. 2 interactions.
MINTiMINT-7894200.

Structurei

3D structure databases

ProteinModelPortaliD3YZU4.
SMRiD3YZU4. Positions 656-759, 2093-2154.

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.
Contains 6 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotations, RepeatUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
KOiK15009.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YZU4-1 [UniParc]FASTAAdd to Basket

« Hide

MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN     50
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 100
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 150
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 200
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 250
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 300
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 350
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR 400
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV 450
FSAPGASSSG TPGPTSGSQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP 500
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL 550
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 600
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG 650
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 700
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 750
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMEYEQ 800
QPAAVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH 850
RPKGFFATES SFDPHHRSQP SYDRPSFLPP GPGLMLRQKS IGAAEDDRPY 900
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPAPS SSGRLTPSPR 950
GGPFNPGSGG PLPASSPSSF DGPSPPDPRS GGREKSLYHS GALPPAHHHP 1000
PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW 1050
RGGGPSPTSG APSPSHHSSS GGSSGPAQAP ALRYFQLPPR AASAAMYVPA 1100
RSGRGRKGPL VKQTKVEGEP QKGSLPPASS PTSPALPRSE PPPAGPSEKN 1150
SIPIPTIIIK APSTSSSGRS SQGSSTEAEP PTQPDGAGGG GSSPSPAPAT 1200
SPVPPSPSPV PTPASPSGPA TLDFTSQFGA ALVGAARREG GWQNEARRRS 1250
TLFLSTDAGD EDGGDSGLGP GAPPGPRLRH SKSIDEGMFS AEPYLRLESG 1300
GSSGGYGAYA AGSRAYGGSG SSSAFTSFLP PRPLVHPLTG KALDPASPLG 1350
LALAARERAL KESSEGGVTP QPPPRPPSPR YDAPPPTLHH HSPHSPHSPH 1400
ARHEPVLRLW GDPARRELGY RAGLGSQEKA LTASPPAARR SLLHRLPPTA 1450
PGVGPLLLQL GPEPPTPHPG VSKAWRTAAP EEPERLPLHV RFLENCQARP 1500
PPAGTRGSST EDGPGVPPPS PRRVLPTSPT SPRGNEENGL PLLVLPPPAP 1550
SVDVDDGEFL FAEPLPPPLE FSNSFEKPES PLTPGPPHPL PDPPSPATPL 1600
PAAPPPAVAA APPTLDSTAS SLTSYDSEVA TLTQGAPAAP GDPPAPGPPA 1650
PAAPAPPAPQ PGPDPPPGTD SGIEEVDSRS SSDHPLETIS SASTLSSLSA 1700
EGGGNTGGVA GGGAGVASGT ELLDTYVAYL DGQAFGGSGT PGPPYPPQLM 1750
TPSKLRGRAL GTSGNLRPGP SGGLRDPVTP TSPTVSVTGA GTDGLLALSA 1800
CSGPSTAGVA GGPVAVEPEV PPVPLPTASS LPRKLLPWEE GPGPPPPPLP 1850
GPLSQPQASA LATVKASIIS ELSSKLQQFG GASTAGGALP WARGGSGGST 1900
DSHHGGASYI PERTSSLQRQ RLSEDSQTSL LSKPSSSIFQ NWPKPPLPPL 1950
PTGSGVSSST AAAPGATSPS ASSASASTRH LQGVEFEMRP PLLRRAPSPS 2000
LLPASDHKVS PAPRPSSLPI LPSGPLYPGL FDIRSSPTGG AGGSADPFAP 2050
VFVPPHPGIS GGLGGALSGA SRSLSPTRLL SLPPDKPFGA KPLGFWTKFD 2100
VADWLEWLGL SEHRAQFLDH EIDGSHLPAL TKEDYVDLGV TRVGHRMNID 2150
RALKFFLER 2159
Length:2,159
Mass (Da):225,350
Last modified:April 20, 2010 - v1
Checksum:i78EA8FD9E436C06F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC152939 Genomic DNA. No translation available.
RefSeqiXP_006540928.1. XM_006540865.1.
UniGeneiMm.360368.

Genome annotation databases

EnsembliENSMUST00000107935; ENSMUSP00000103568; ENSMUSG00000038738.
GeneIDi243961.
KEGGimmu:243961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC152939 Genomic DNA. No translation available.
RefSeqi XP_006540928.1. XM_006540865.1.
UniGenei Mm.360368.

3D structure databases

ProteinModelPortali D3YZU4.
SMRi D3YZU4. Positions 656-759, 2093-2154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi D3YZU4. 2 interactions.
MINTi MINT-7894200.

Proteomic databases

PRIDEi D3YZU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107935 ; ENSMUSP00000103568 ; ENSMUSG00000038738 .
GeneIDi 243961.
KEGGi mmu:243961.

Organism-specific databases

CTDi 50944.
MGIi MGI:3613677. Shank1.

Phylogenomic databases

GeneTreei ENSGT00510000046474.
HOGENOMi HOG000293276.
KOi K15009.

Miscellaneous databases

NextBioi 35549888.
SOURCEi Search...

Gene expression databases

ArrayExpressi D3YZU4.
Bgeei D3YZU4.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YZU4_MOUSE
AccessioniPrimary (citable) accession number: D3YZU4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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