Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D3YZU4

- D3YZU4_MOUSE

UniProt

D3YZU4 - D3YZU4_MOUSE

Protein
Submitted name:

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. negative regulation of actin filament bundle assembly Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    SH3 and multiple ankyrin repeat domains protein 1Imported
    Gene namesi
    Name:Shank1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:3613677. Shank1.

    Subcellular locationi

    GO - Cellular componenti

    1. postsynaptic membrane Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiD3YZU4.

    Expressioni

    Gene expression databases

    ArrayExpressiD3YZU4.
    BgeeiD3YZU4.

    Interactioni

    Protein-protein interaction databases

    IntActiD3YZU4. 2 interactions.
    MINTiMINT-7894200.

    Structurei

    3D structure databases

    ProteinModelPortaliD3YZU4.
    SMRiD3YZU4. Positions 656-759, 2093-2154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.
    Contains 6 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00510000046474.
    HOGENOMiHOG000293276.
    KOiK15009.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 6 hits.
    SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3YZU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN     50
    LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 100
    QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 150
    YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 200
    KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 250
    LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 300
    LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 350
    LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR 400
    NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV 450
    FSAPGASSSG TPGPTSGSQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP 500
    SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL 550
    YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 600
    GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG 650
    IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 700
    YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 750
    VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMEYEQ 800
    QPAAVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH 850
    RPKGFFATES SFDPHHRSQP SYDRPSFLPP GPGLMLRQKS IGAAEDDRPY 900
    LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPAPS SSGRLTPSPR 950
    GGPFNPGSGG PLPASSPSSF DGPSPPDPRS GGREKSLYHS GALPPAHHHP 1000
    PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW 1050
    RGGGPSPTSG APSPSHHSSS GGSSGPAQAP ALRYFQLPPR AASAAMYVPA 1100
    RSGRGRKGPL VKQTKVEGEP QKGSLPPASS PTSPALPRSE PPPAGPSEKN 1150
    SIPIPTIIIK APSTSSSGRS SQGSSTEAEP PTQPDGAGGG GSSPSPAPAT 1200
    SPVPPSPSPV PTPASPSGPA TLDFTSQFGA ALVGAARREG GWQNEARRRS 1250
    TLFLSTDAGD EDGGDSGLGP GAPPGPRLRH SKSIDEGMFS AEPYLRLESG 1300
    GSSGGYGAYA AGSRAYGGSG SSSAFTSFLP PRPLVHPLTG KALDPASPLG 1350
    LALAARERAL KESSEGGVTP QPPPRPPSPR YDAPPPTLHH HSPHSPHSPH 1400
    ARHEPVLRLW GDPARRELGY RAGLGSQEKA LTASPPAARR SLLHRLPPTA 1450
    PGVGPLLLQL GPEPPTPHPG VSKAWRTAAP EEPERLPLHV RFLENCQARP 1500
    PPAGTRGSST EDGPGVPPPS PRRVLPTSPT SPRGNEENGL PLLVLPPPAP 1550
    SVDVDDGEFL FAEPLPPPLE FSNSFEKPES PLTPGPPHPL PDPPSPATPL 1600
    PAAPPPAVAA APPTLDSTAS SLTSYDSEVA TLTQGAPAAP GDPPAPGPPA 1650
    PAAPAPPAPQ PGPDPPPGTD SGIEEVDSRS SSDHPLETIS SASTLSSLSA 1700
    EGGGNTGGVA GGGAGVASGT ELLDTYVAYL DGQAFGGSGT PGPPYPPQLM 1750
    TPSKLRGRAL GTSGNLRPGP SGGLRDPVTP TSPTVSVTGA GTDGLLALSA 1800
    CSGPSTAGVA GGPVAVEPEV PPVPLPTASS LPRKLLPWEE GPGPPPPPLP 1850
    GPLSQPQASA LATVKASIIS ELSSKLQQFG GASTAGGALP WARGGSGGST 1900
    DSHHGGASYI PERTSSLQRQ RLSEDSQTSL LSKPSSSIFQ NWPKPPLPPL 1950
    PTGSGVSSST AAAPGATSPS ASSASASTRH LQGVEFEMRP PLLRRAPSPS 2000
    LLPASDHKVS PAPRPSSLPI LPSGPLYPGL FDIRSSPTGG AGGSADPFAP 2050
    VFVPPHPGIS GGLGGALSGA SRSLSPTRLL SLPPDKPFGA KPLGFWTKFD 2100
    VADWLEWLGL SEHRAQFLDH EIDGSHLPAL TKEDYVDLGV TRVGHRMNID 2150
    RALKFFLER 2159
    Length:2,159
    Mass (Da):225,350
    Last modified:April 20, 2010 - v1
    Checksum:i78EA8FD9E436C06F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152939 Genomic DNA. No translation available.
    RefSeqiXP_006540928.1. XM_006540865.1.
    UniGeneiMm.360368.

    Genome annotation databases

    EnsembliENSMUST00000107935; ENSMUSP00000103568; ENSMUSG00000038738.
    GeneIDi243961.
    KEGGimmu:243961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152939 Genomic DNA. No translation available.
    RefSeqi XP_006540928.1. XM_006540865.1.
    UniGenei Mm.360368.

    3D structure databases

    ProteinModelPortali D3YZU4.
    SMRi D3YZU4. Positions 656-759, 2093-2154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi D3YZU4. 2 interactions.
    MINTi MINT-7894200.

    Proteomic databases

    PRIDEi D3YZU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107935 ; ENSMUSP00000103568 ; ENSMUSG00000038738 .
    GeneIDi 243961.
    KEGGi mmu:243961.

    Organism-specific databases

    CTDi 50944.
    MGIi MGI:3613677. Shank1.

    Phylogenomic databases

    GeneTreei ENSGT00510000046474.
    HOGENOMi HOG000293276.
    KOi K15009.

    Miscellaneous databases

    NextBioi 35549888.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D3YZU4.
    Bgeei D3YZU4.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 6 hits.
    SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiD3YZU4_MOUSE
    AccessioniPrimary (citable) accession number: D3YZU4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3