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Protein
Submitted name:

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. adult behavior Source: MGI
  2. determination of affect Source: MGI
  3. negative regulation of actin filament bundle assembly Source: MGI
  4. social behavior Source: MGI
  5. vocalization behavior Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 and multiple ankyrin repeat domains protein 1Imported
Gene namesi
Name:Shank1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:3613677. Shank1.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: MGI
  2. postsynaptic membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3YZU4.

Expressioni

Gene expression databases

BgeeiD3YZU4.
ExpressionAtlasiD3YZU4. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiD3YZU4. 2 interactions.
MINTiMINT-7894200.

Structurei

3D structure databases

ProteinModelPortaliD3YZU4.
SMRiD3YZU4. Positions 656-759, 2093-2154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains 6 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
KOiK15009.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YZU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN
60 70 80 90 100
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGASSSG TPGPTSGSQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG
660 670 680 690 700
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMEYEQ
810 820 830 840 850
QPAAVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH
860 870 880 890 900
RPKGFFATES SFDPHHRSQP SYDRPSFLPP GPGLMLRQKS IGAAEDDRPY
910 920 930 940 950
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPAPS SSGRLTPSPR
960 970 980 990 1000
GGPFNPGSGG PLPASSPSSF DGPSPPDPRS GGREKSLYHS GALPPAHHHP
1010 1020 1030 1040 1050
PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW
1060 1070 1080 1090 1100
RGGGPSPTSG APSPSHHSSS GGSSGPAQAP ALRYFQLPPR AASAAMYVPA
1110 1120 1130 1140 1150
RSGRGRKGPL VKQTKVEGEP QKGSLPPASS PTSPALPRSE PPPAGPSEKN
1160 1170 1180 1190 1200
SIPIPTIIIK APSTSSSGRS SQGSSTEAEP PTQPDGAGGG GSSPSPAPAT
1210 1220 1230 1240 1250
SPVPPSPSPV PTPASPSGPA TLDFTSQFGA ALVGAARREG GWQNEARRRS
1260 1270 1280 1290 1300
TLFLSTDAGD EDGGDSGLGP GAPPGPRLRH SKSIDEGMFS AEPYLRLESG
1310 1320 1330 1340 1350
GSSGGYGAYA AGSRAYGGSG SSSAFTSFLP PRPLVHPLTG KALDPASPLG
1360 1370 1380 1390 1400
LALAARERAL KESSEGGVTP QPPPRPPSPR YDAPPPTLHH HSPHSPHSPH
1410 1420 1430 1440 1450
ARHEPVLRLW GDPARRELGY RAGLGSQEKA LTASPPAARR SLLHRLPPTA
1460 1470 1480 1490 1500
PGVGPLLLQL GPEPPTPHPG VSKAWRTAAP EEPERLPLHV RFLENCQARP
1510 1520 1530 1540 1550
PPAGTRGSST EDGPGVPPPS PRRVLPTSPT SPRGNEENGL PLLVLPPPAP
1560 1570 1580 1590 1600
SVDVDDGEFL FAEPLPPPLE FSNSFEKPES PLTPGPPHPL PDPPSPATPL
1610 1620 1630 1640 1650
PAAPPPAVAA APPTLDSTAS SLTSYDSEVA TLTQGAPAAP GDPPAPGPPA
1660 1670 1680 1690 1700
PAAPAPPAPQ PGPDPPPGTD SGIEEVDSRS SSDHPLETIS SASTLSSLSA
1710 1720 1730 1740 1750
EGGGNTGGVA GGGAGVASGT ELLDTYVAYL DGQAFGGSGT PGPPYPPQLM
1760 1770 1780 1790 1800
TPSKLRGRAL GTSGNLRPGP SGGLRDPVTP TSPTVSVTGA GTDGLLALSA
1810 1820 1830 1840 1850
CSGPSTAGVA GGPVAVEPEV PPVPLPTASS LPRKLLPWEE GPGPPPPPLP
1860 1870 1880 1890 1900
GPLSQPQASA LATVKASIIS ELSSKLQQFG GASTAGGALP WARGGSGGST
1910 1920 1930 1940 1950
DSHHGGASYI PERTSSLQRQ RLSEDSQTSL LSKPSSSIFQ NWPKPPLPPL
1960 1970 1980 1990 2000
PTGSGVSSST AAAPGATSPS ASSASASTRH LQGVEFEMRP PLLRRAPSPS
2010 2020 2030 2040 2050
LLPASDHKVS PAPRPSSLPI LPSGPLYPGL FDIRSSPTGG AGGSADPFAP
2060 2070 2080 2090 2100
VFVPPHPGIS GGLGGALSGA SRSLSPTRLL SLPPDKPFGA KPLGFWTKFD
2110 2120 2130 2140 2150
VADWLEWLGL SEHRAQFLDH EIDGSHLPAL TKEDYVDLGV TRVGHRMNID

RALKFFLER
Length:2,159
Mass (Da):225,350
Last modified:April 20, 2010 - v1
Checksum:i78EA8FD9E436C06F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152939 Genomic DNA. No translation available.
RefSeqiXP_006540928.1. XM_006540865.1.
UniGeneiMm.360368.

Genome annotation databases

EnsembliENSMUST00000107935; ENSMUSP00000103568; ENSMUSG00000038738.
GeneIDi243961.
KEGGimmu:243961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152939 Genomic DNA. No translation available.
RefSeqiXP_006540928.1. XM_006540865.1.
UniGeneiMm.360368.

3D structure databases

ProteinModelPortaliD3YZU4.
SMRiD3YZU4. Positions 656-759, 2093-2154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3YZU4. 2 interactions.
MINTiMINT-7894200.

Proteomic databases

PRIDEiD3YZU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107935; ENSMUSP00000103568; ENSMUSG00000038738.
GeneIDi243961.
KEGGimmu:243961.

Organism-specific databases

CTDi50944.
MGIiMGI:3613677. Shank1.

Phylogenomic databases

GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
KOiK15009.

Miscellaneous databases

NextBioi35549888.
SOURCEiSearch...

Gene expression databases

BgeeiD3YZU4.
ExpressionAtlasiD3YZU4. baseline and differential.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YZU4_MOUSE
AccessioniPrimary (citable) accession number: D3YZU4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.