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Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adult behavior Source: MGI
  • associative learning Source: BHF-UCL
  • dendritic spine morphogenesis Source: BHF-UCL
  • determination of affect Source: MGI
  • habituation Source: BHF-UCL
  • long-term memory Source: BHF-UCL
  • negative regulation of actin filament bundle assembly Source: MGI
  • neuromuscular process controlling balance Source: BHF-UCL
  • olfactory behavior Source: BHF-UCL
  • positive regulation of dendritic spine development Source: BHF-UCL
  • positive regulation of excitatory postsynaptic potential Source: BHF-UCL
  • protein complex assembly Source: BHF-UCL
  • protein localization to synapse Source: BHF-UCL
  • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  • righting reflex Source: BHF-UCL
  • social behavior Source: BHF-UCL
  • synapse maturation Source: BHF-UCL
  • vocalization behavior Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Gene namesi
Name:Shank1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3613677. Shank1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • dendrite Source: BHF-UCL
  • dendritic spine Source: BHF-UCL
  • excitatory synapse Source: BHF-UCL
  • membrane Source: MGI
  • neuron projection Source: BHF-UCL
  • NMDA selective glutamate receptor complex Source: Ensembl
  • plasma membrane Source: BHF-UCL
  • postsynaptic density Source: BHF-UCL
  • postsynaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21672167SH3 and multiple ankyrin repeat domains protein 1PRO_0000411019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861PhosphotyrosineCombined sources
Modified residuei540 – 5401PhosphoserineCombined sources
Modified residuei671 – 6711PhosphoserineCombined sources
Modified residuei791 – 7911PhosphoserineCombined sources
Modified residuei898 – 8981PhosphoserineCombined sources
Modified residuei1291 – 12911PhosphoserineCombined sources
Modified residuei1442 – 14421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiD3YZU1.
PaxDbiD3YZU1.
PeptideAtlasiD3YZU1.
PRIDEiD3YZU1.

PTM databases

iPTMnetiD3YZU1.
PhosphoSiteiD3YZU1.

Expressioni

Tissue specificityi

In brain, highly expressed in cortex, hyppocampus and cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000038738.
ExpressionAtlasiD3YZU1. baseline and differential.
GenevisibleiD3YZU1. MM.

Interactioni

Subunit structurei

May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2. Interacts with IGSF9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232591. 1 interaction.
IntActiD3YZU1. 1 interaction.
STRINGi10090.ENSMUSP00000103571.

Structurei

3D structure databases

ProteinModelPortaliD3YZU1.
SMRiD3YZU1. Positions 656-759, 2101-2162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati212 – 24231ANK 1Add
BLAST
Repeati246 – 27530ANK 2Add
BLAST
Repeati279 – 30931ANK 3Add
BLAST
Repeati313 – 34230ANK 4Add
BLAST
Repeati346 – 37530ANK 5Add
BLAST
Repeati379 – 40729ANK 6Add
BLAST
Domaini554 – 61360SH3PROSITE-ProRule annotationAdd
BLAST
Domaini663 – 75795PDZPROSITE-ProRule annotationAdd
BLAST
Domaini2104 – 216764SAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi878 – 1675798Pro-richAdd
BLAST
Compositional biasi1005 – 103026His-richAdd
BLAST
Compositional biasi1710 – 1820111Gly-richAdd
BLAST
Compositional biasi1821 – 186444Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SHANK family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4375. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
InParanoidiD3YZU1.
KOiK15009.
OMAiWQNEARR.
OrthoDBiEOG091G00OW.
TreeFamiTF324593.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032425. FERM_f0.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16511. FERM_f0. 1 hit.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YZU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN
60 70 80 90 100
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGASSSG TPGPTSGSQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG
660 670 680 690 700
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMVSPW
810 820 830 840 850
KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG
860 870 880 890 900
GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG
910 920 930 940 950
AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS
960 970 980 990 1000
GRLTPSPRGG PFNPGSGGPL PASSPSSFDG PSPPDPRSGG REKSLYHSGA
1010 1020 1030 1040 1050
LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG
1060 1070 1080 1090 1100
PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG SSGPAQAPAL RYFQLPPRAA
1110 1120 1130 1140 1150
SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSLPPASSPT SPALPRSEPP
1160 1170 1180 1190 1200
PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS
1210 1220 1230 1240 1250
SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW
1260 1270 1280 1290 1300
QNEARRRSTL FLSTDAGDED GGDSGLGPGA PPGPRLRHSK SIDEGMFSAE
1310 1320 1330 1340 1350
PYLRLESGGS SGGYGAYAAG SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA
1360 1370 1380 1390 1400
LDPASPLGLA LAARERALKE SSEGGVTPQP PPRPPSPRYD APPPTLHHHS
1410 1420 1430 1440 1450
PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT ASPPAARRSL
1460 1470 1480 1490 1500
LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF
1510 1520 1530 1540 1550
LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL
1560 1570 1580 1590 1600
LVLPPPAPSV DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD
1610 1620 1630 1640 1650
PPSPATPLPA APPPAVAAAP PTLDSTASSL TSYDSEVATL TQGAPAAPGD
1660 1670 1680 1690 1700
PPAPGPPAPA APAPPAPQPG PDPPPGTDSG IEEVDSRSSS DHPLETISSA
1710 1720 1730 1740 1750
STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG QAFGGSGTPG
1760 1770 1780 1790 1800
PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT
1810 1820 1830 1840 1850
DGLLALSACS GPSTAGVAGG PVAVEPEVPP VPLPTASSLP RKLLPWEEGP
1860 1870 1880 1890 1900
GPPPPPLPGP LSQPQASALA TVKASIISEL SSKLQQFGGA STAGGALPWA
1910 1920 1930 1940 1950
RGGSGGSTDS HHGGASYIPE RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW
1960 1970 1980 1990 2000
PKPPLPPLPT GSGVSSSTAA APGATSPSAS SASASTRHLQ GVEFEMRPPL
2010 2020 2030 2040 2050
LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPLYPGLFD IRSSPTGGAG
2060 2070 2080 2090 2100
GSADPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP
2110 2120 2130 2140 2150
LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR
2160
VGHRMNIDRA LKFFLER
Length:2,167
Mass (Da):226,317
Last modified:April 20, 2010 - v1
Checksum:iA732912793A975AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti939 – 9391P → R in CO436178 (PubMed:15033168).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152939 Genomic DNA. No translation available.
CO436178 mRNA. No translation available.
CCDSiCCDS52229.1.
RefSeqiNP_001029287.1. NM_001034115.1.
XP_006540927.1. XM_006540864.2.
UniGeneiMm.360368.

Genome annotation databases

EnsembliENSMUST00000107938; ENSMUSP00000103571; ENSMUSG00000038738.
GeneIDi243961.
KEGGimmu:243961.
UCSCiuc012fjo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152939 Genomic DNA. No translation available.
CO436178 mRNA. No translation available.
CCDSiCCDS52229.1.
RefSeqiNP_001029287.1. NM_001034115.1.
XP_006540927.1. XM_006540864.2.
UniGeneiMm.360368.

3D structure databases

ProteinModelPortaliD3YZU1.
SMRiD3YZU1. Positions 656-759, 2101-2162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232591. 1 interaction.
IntActiD3YZU1. 1 interaction.
STRINGi10090.ENSMUSP00000103571.

PTM databases

iPTMnetiD3YZU1.
PhosphoSiteiD3YZU1.

Proteomic databases

MaxQBiD3YZU1.
PaxDbiD3YZU1.
PeptideAtlasiD3YZU1.
PRIDEiD3YZU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107938; ENSMUSP00000103571; ENSMUSG00000038738.
GeneIDi243961.
KEGGimmu:243961.
UCSCiuc012fjo.1. mouse.

Organism-specific databases

CTDi50944.
MGIiMGI:3613677. Shank1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4375. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
InParanoidiD3YZU1.
KOiK15009.
OMAiWQNEARR.
OrthoDBiEOG091G00OW.
TreeFamiTF324593.

Miscellaneous databases

PROiD3YZU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038738.
ExpressionAtlasiD3YZU1. baseline and differential.
GenevisibleiD3YZU1. MM.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032425. FERM_f0.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16511. FERM_f0. 1 hit.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHAN1_MOUSE
AccessioniPrimary (citable) accession number: D3YZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.