UniProtKB - D3YYC3 (D3YYC3_MOUSE)
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Protein
Histone-lysine N-methyltransferase
Gene
Setdb1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation
GO - Molecular functioni
- DNA binding Source: InterPro
- histone-lysine N-methyltransferase activity Source: UniProtKB-UniRule
- promoter-specific chromatin binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- positive regulation of methylation-dependent chromatin silencing Source: Ensembl
- Ras protein signal transduction Source: Ensembl
- response to ethanol Source: Ensembl
- response to vitamin Source: Ensembl
Keywordsi
Molecular function | MethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase |
Ligand | S-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation |
Enzyme and pathway databases
Reactomei | R-MMU-3214841. PKMTs methylate histone lysines. |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation) |
Gene namesi | Name:Setdb1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1934229. Setdb1. |
Subcellular locationi
Keywords - Cellular componenti
ChromosomeSAAS annotation, NucleusSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 612 – 683 | MBDInterPro annotationAdd BLAST | 72 | |
Domaini | 745 – 818 | Pre-SETInterPro annotationAdd BLAST | 74 | |
Domaini | 821 – 1283 | SETInterPro annotationAdd BLAST | 463 | |
Domaini | 1292 – 1308 | Post-SETInterPro annotationAdd BLAST | 17 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 37 – 64 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1141. Eukaryota. COG2940. LUCA. |
GeneTreei | ENSGT00780000121845. |
HOGENOMi | HOG000154292. |
KOi | K11421. |
OMAi | TSMHQSR. |
OrthoDBi | EOG091G014F. |
TreeFami | TF106411. |
Family and domain databases
InterProi | View protein in InterPro IPR016177. DNA-bd_dom_sf. IPR025796. Hist-Lys_N-MeTrfase_SETDB1. IPR001739. Methyl_CpG_DNA-bd. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR001214. SET_dom. IPR002999. Tudor. |
Pfami | View protein in Pfam PF01429. MBD. 1 hit. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. |
SMARTi | View protein in SMART SM00391. MBD. 1 hit. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. SM00333. TUDOR. 2 hits. |
SUPFAMi | SSF54171. SSF54171. 1 hit. |
PROSITEi | View protein in PROSITE PS50982. MBD. 1 hit. PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS51573. SAM_MT43_SUVAR39_1. 1 hit. PS50280. SET. 1 hit. |
i Sequence
Sequence statusi: Complete.
D3YYC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK
60 70 80 90 100
MDCIQQRKKQ LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY
110 120 130 140 150
SKLGLQYHDS SSEDEASRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL
160 170 180 190 200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLGQVSG ELSKDGDLIV
210 220 230 240 250
SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS LLSGNHIAYD
260 270 280 290 300
YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
310 320 330 340 350
YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS
360 370 380 390 400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS
410 420 430 440 450
MKTSSASAME KKQGGQLRTR PNMGAVRSKG PVVQYTQDLT GTGIQFKPME
460 470 480 490 500
PLQPIAPPAP LPIPPLSPQA ADTESLESQL AQSRKQVAKK STSFRPGSVG
510 520 530 540 550
SGHSSPTSST LSENVSAGKL GINQTYRSPL ASVTSTPASA APPVPPVPPG
560 570 580 590 600
PPTPPGPPAP PGPLAPPAFH GMLERAPAEP SYRAPMEKLF YLPHVCSYTC
610 620 630 640 650
LSRIRPMRNE QYRGKNPLLV PLLYDFRRMT ARRRVNRKMG FHVIYKTPCG
660 670 680 690 700
LCLRTMQEIE RYLFETGCDF LFLEMFCLDP YVLVDRKFQP FKPFYYILDI
710 720 730 740 750
TYGKEDVPLS CVNEIDTTPP PQVAYSKERI PGKGVFINTG PEFLVGCDCK
760 770 780 790 800
DGCRDKSKCA CHQLTIQATA CTPGGQVNPN SGYQYKRLEE CLPTGVYECN
810 820 830 840 850
KRCNCDPNMC TNRLVQHGLQ VRLQLFKTQN KGWGIRCLDD IAKGSFVCIY
860 870 880 890 900
AGKILTDDFA DKEGLEMGDE YFANLDHIES VENFKEGYES DVPTSSDSSG
910 920 930 940 950
VDMKDQEDGN SGSEDPEESN DDSSDDNFCK DEDFSTSSVW RSYATRRQTR
960 970 980 990 1000
GQKENELSEM TSKDSRPPDL GPPHVPIPSS VSVGGCNPPS SEETPKNKVA
1010 1020 1030 1040 1050
SWLSCNSVSE GGFADSDSRS SFKTSEGGDG RAGGGRGEAE RASTSGLSFK
1060 1070 1080 1090 1100
DEGDNKQPKK EDPENRNKMP VVTEGSQNHG HNPPMKSEGL RRSASKMSVL
1110 1120 1130 1140 1150
QSQRVVTSTQ SNPDDILTLS SSTESEGESG TSRKPTAGHT SATAVDSDDI
1160 1170 1180 1190 1200
QTISSGSDGD DFEDKKNLSG PTKRQVAVKS TRGFALKSTH GIAIKSTNMA
1210 1220 1230 1240 1250
SVDKGESAPV RKNTRQFYDG EESCYIIDAK LEGNLGRYLN HSCSPNLFVQ
1260 1270 1280 1290 1300
NVFVDTHDLR FPWVAFFASK RIRAGTELTW DYNYEVGSVE GKELLCCCGA
IECRGRLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092202 Genomic DNA. No translation available. |
RefSeqi | NP_001157113.1. NM_001163641.1. NP_061365.3. NM_018877.3. |
UniGenei | Mm.490259. |
Genome annotation databases
Ensembli | ENSMUST00000015841; ENSMUSP00000015841; ENSMUSG00000015697. ENSMUST00000107170; ENSMUSP00000102788; ENSMUSG00000015697. |
GeneIDi | 84505. |
KEGGi | mmu:84505. |
UCSCi | uc008qjl.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | D3YYC3_MOUSE | |
Accessioni | D3YYC3Primary (citable) accession number: D3YYC3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | March 28, 2018 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |