Histone-lysine N-methyltransferase

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: InterPro
• histone-lysine N-methyltransferase activity Source: UniProtKB-UniRule
• promoter-specific chromatin binding Source: Ensembl
• zinc ion binding Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• positive regulation of methylation-dependent chromatin silencing Source: Ensembl
• Ras protein signal transduction Source: Ensembl
• response to ethanol Source: Ensembl
• response to vitamin Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK 
        60         70         80         90        100
MDCIQQRKKQ LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY 
       110        120        130        140        150
SKLGLQYHDS SSEDEASRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL 
       160        170        180        190        200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLGQVSG ELSKDGDLIV 
       210        220        230        240        250
SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS LLSGNHIAYD 
       260        270        280        290        300
YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 
       310        320        330        340        350
YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS 
       360        370        380        390        400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS 
       410        420        430        440        450
MKTSSASAME KKQGGQLRTR PNMGAVRSKG PVVQYTQDLT GTGIQFKPME 
       460        470        480        490        500
PLQPIAPPAP LPIPPLSPQA ADTESLESQL AQSRKQVAKK STSFRPGSVG 
       510        520        530        540        550
SGHSSPTSST LSENVSAGKL GINQTYRSPL ASVTSTPASA APPVPPVPPG 
       560        570        580        590        600
PPTPPGPPAP PGPLAPPAFH GMLERAPAEP SYRAPMEKLF YLPHVCSYTC 
       610        620        630        640        650
LSRIRPMRNE QYRGKNPLLV PLLYDFRRMT ARRRVNRKMG FHVIYKTPCG 
       660        670        680        690        700
LCLRTMQEIE RYLFETGCDF LFLEMFCLDP YVLVDRKFQP FKPFYYILDI 
       710        720        730        740        750
TYGKEDVPLS CVNEIDTTPP PQVAYSKERI PGKGVFINTG PEFLVGCDCK 
       760        770        780        790        800
DGCRDKSKCA CHQLTIQATA CTPGGQVNPN SGYQYKRLEE CLPTGVYECN 
       810        820        830        840        850
KRCNCDPNMC TNRLVQHGLQ VRLQLFKTQN KGWGIRCLDD IAKGSFVCIY 
       860        870        880        890        900
AGKILTDDFA DKEGLEMGDE YFANLDHIES VENFKEGYES DVPTSSDSSG 
       910        920        930        940        950
VDMKDQEDGN SGSEDPEESN DDSSDDNFCK DEDFSTSSVW RSYATRRQTR 
       960        970        980        990       1000
GQKENELSEM TSKDSRPPDL GPPHVPIPSS VSVGGCNPPS SEETPKNKVA 
      1010       1020       1030       1040       1050
SWLSCNSVSE GGFADSDSRS SFKTSEGGDG RAGGGRGEAE RASTSGLSFK 
      1060       1070       1080       1090       1100
DEGDNKQPKK EDPENRNKMP VVTEGSQNHG HNPPMKSEGL RRSASKMSVL 
      1110       1120       1130       1140       1150
QSQRVVTSTQ SNPDDILTLS SSTESEGESG TSRKPTAGHT SATAVDSDDI 
      1160       1170       1180       1190       1200
QTISSGSDGD DFEDKKNLSG PTKRQVAVKS TRGFALKSTH GIAIKSTNMA 
      1210       1220       1230       1240       1250
SVDKGESAPV RKNTRQFYDG EESCYIIDAK LEGNLGRYLN HSCSPNLFVQ 
      1260       1270       1280       1290       1300
NVFVDTHDLR FPWVAFFASK RIRAGTELTW DYNYEVGSVE GKELLCCCGA 

IECRGRLL                                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ