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Protein
Submitted name:

Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, isoform CRA_a

Gene

Pik3ca

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, isoform CRA_aImported
Submitted name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformImported
Gene namesi
Name:Pik3caImported
ORF Names:mCG_20268Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1206581. Pik3ca.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSMUSG00000027665.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 167PI3K-RBDInterPro annotationAdd BLAST103
Domaini208 – 365C2 PI3K-typeInterPro annotationAdd BLAST158
Domaini395 – 572PIK helicalInterPro annotationAdd BLAST178
Domaini675 – 946PI3K/PI4KInterPro annotationAdd BLAST272

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000252911.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiView protein in Pfam
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
SMARTiView protein in SMART
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.

Sequencei

Sequence statusi: Complete.

D3YY41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVCEFDMVK DPEVQDFRRN ILNVCKEAVD LRDLNSPHSR AMYVYPPNVE
60 70 80 90 100
SSPELPKHIY NKLDKGQIIV VIWVIVSPNN DKQKYTLKIN HDCVPEQVIA
110 120 130 140 150
EAIRKKTRSM LLSSEQLKLC VLEYQGKYIL KVCGCDEYFL EKYPLSQYKY
160 170 180 190 200
IRSCIMLGRM PNLMLMAKES LYSQLPIDSF TMPSYSRRIS TATPYMNGET
210 220 230 240 250
STKSLWVINS ALRIKILCAT YVNVNIRDID KIYVRTGIYH GGEPLCDNVN
260 270 280 290 300
TQRVPCSNPR WNEWLNYDIY IPDLPRAARL CLSICSVKGR KGAKEEHCPL
310 320 330 340 350
AWGNINLFDY TDTLVSGKMA LNLWPVPHGL EDLLNPIGVT GSNPNKETPC
360 370 380 390 400
LELEFDWFSS VVKFPDMSVI EEHANWSVSR EAGFSYSHTG LSNRLARDNE
410 420 430 440 450
LRENDKEQLR ALCTRDPLSE ITEQEKDFLW SHRHYCVTIP EILPKLLLSV
460 470 480 490 500
KWNSRDEVAQ MYCLVKDWPP IKPEQAMELL DCNYPDPMVR SFAVRCLEKY
510 520 530 540 550
LTDDKLSQYL IQLVQVLKYE QYLDNLLVRF LLKKALTNQR IGHFFFWHLK
560 570 580 590 600
SEMHNKTVSQ RFGLLLESYC RACGMYLKHL NRQVEAMEKL INLTDILKQE
610 620 630 640 650
KKDETQKVQM KFLVEQMRQP DFMDALQGFL SPLNPAHQLG NLRLEECRIM
660 670 680 690 700
SSAKRPLWLN WENPDIMSEL LFQNNEIIFK NGDDLRQDML TLQIIRIMEN
710 720 730 740 750
IWQNQGLDLR MLPYGCLSIG DCVGLIEVVR NSHTIMQIQC KGGLKGALQF
760 770 780 790 800
NSHTLHQWLK DKNKGEIYDA AIDLFTRSCA GYCVATFILG IGDRHNSNIM
810 820 830 840 850
VKDDGQLFHI DFGHFLDHKK KKFGYKRERV PFVLTQDFLI VISKGAQEYT
860 870 880 890 900
KTREFERFQE MCYKAYLAIR QHANLFINLF SMMLGSGMPE LQSFDDIAYI
910 920 930 940
RKTLALDKTE QEALEYFTKQ MNDAHHGGWT TKMDWIFHTI KQHALN
Length:946
Mass (Da):110,138
Last modified:April 20, 2010 - v1
Checksum:i9C3C87E622B323D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110034 Genomic DNA. No translation available.
AC130281 Genomic DNA. No translation available.
CH466530 Genomic DNA. Translation: EDL34989.1.
UniGeneiMm.260521.

Genome annotation databases

EnsembliENSMUST00000108242; ENSMUSP00000103877; ENSMUSG00000027665.

Similar proteinsi

Entry informationi

Entry nameiD3YY41_MOUSE
AccessioniPrimary (citable) accession number: D3YY41
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: August 30, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported