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Protein
Submitted name:

Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, isoform CRA_a

Gene

Pik3ca

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, isoform CRA_aImported
Submitted name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformImported
Gene namesi
Name:Pik3caImported
ORF Names:mCG_20268Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1206581. Pik3ca.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiD3YY41.

Expressioni

Gene expression databases

ExpressionAtlasiD3YY41. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029201.

Structurei

3D structure databases

SMRiD3YY41. Positions 1-924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 167103PI3K-RBDInterPro annotationAdd
BLAST
Domaini208 – 365158C2 PI3K-typeInterPro annotationAdd
BLAST
Domaini395 – 572178PIK helicalInterPro annotationAdd
BLAST
Domaini675 – 946272PI3K/PI4KInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation
Contains PI3K/PI4K domain.SAAS annotation
Contains PIK helical domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000252911.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YY41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVCEFDMVK DPEVQDFRRN ILNVCKEAVD LRDLNSPHSR AMYVYPPNVE
60 70 80 90 100
SSPELPKHIY NKLDKGQIIV VIWVIVSPNN DKQKYTLKIN HDCVPEQVIA
110 120 130 140 150
EAIRKKTRSM LLSSEQLKLC VLEYQGKYIL KVCGCDEYFL EKYPLSQYKY
160 170 180 190 200
IRSCIMLGRM PNLMLMAKES LYSQLPIDSF TMPSYSRRIS TATPYMNGET
210 220 230 240 250
STKSLWVINS ALRIKILCAT YVNVNIRDID KIYVRTGIYH GGEPLCDNVN
260 270 280 290 300
TQRVPCSNPR WNEWLNYDIY IPDLPRAARL CLSICSVKGR KGAKEEHCPL
310 320 330 340 350
AWGNINLFDY TDTLVSGKMA LNLWPVPHGL EDLLNPIGVT GSNPNKETPC
360 370 380 390 400
LELEFDWFSS VVKFPDMSVI EEHANWSVSR EAGFSYSHTG LSNRLARDNE
410 420 430 440 450
LRENDKEQLR ALCTRDPLSE ITEQEKDFLW SHRHYCVTIP EILPKLLLSV
460 470 480 490 500
KWNSRDEVAQ MYCLVKDWPP IKPEQAMELL DCNYPDPMVR SFAVRCLEKY
510 520 530 540 550
LTDDKLSQYL IQLVQVLKYE QYLDNLLVRF LLKKALTNQR IGHFFFWHLK
560 570 580 590 600
SEMHNKTVSQ RFGLLLESYC RACGMYLKHL NRQVEAMEKL INLTDILKQE
610 620 630 640 650
KKDETQKVQM KFLVEQMRQP DFMDALQGFL SPLNPAHQLG NLRLEECRIM
660 670 680 690 700
SSAKRPLWLN WENPDIMSEL LFQNNEIIFK NGDDLRQDML TLQIIRIMEN
710 720 730 740 750
IWQNQGLDLR MLPYGCLSIG DCVGLIEVVR NSHTIMQIQC KGGLKGALQF
760 770 780 790 800
NSHTLHQWLK DKNKGEIYDA AIDLFTRSCA GYCVATFILG IGDRHNSNIM
810 820 830 840 850
VKDDGQLFHI DFGHFLDHKK KKFGYKRERV PFVLTQDFLI VISKGAQEYT
860 870 880 890 900
KTREFERFQE MCYKAYLAIR QHANLFINLF SMMLGSGMPE LQSFDDIAYI
910 920 930 940
RKTLALDKTE QEALEYFTKQ MNDAHHGGWT TKMDWIFHTI KQHALN
Length:946
Mass (Da):110,138
Last modified:April 20, 2010 - v1
Checksum:i9C3C87E622B323D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110034 Genomic DNA. No translation available.
AC130281 Genomic DNA. No translation available.
CH466530 Genomic DNA. Translation: EDL34989.1.
UniGeneiMm.260521.

Genome annotation databases

EnsembliENSMUST00000108242; ENSMUSP00000103877; ENSMUSG00000027665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110034 Genomic DNA. No translation available.
AC130281 Genomic DNA. No translation available.
CH466530 Genomic DNA. Translation: EDL34989.1.
UniGeneiMm.260521.

3D structure databases

SMRiD3YY41. Positions 1-924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029201.

Proteomic databases

MaxQBiD3YY41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108242; ENSMUSP00000103877; ENSMUSG00000027665.

Organism-specific databases

MGIiMGI:1206581. Pik3ca.

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000252911.

Miscellaneous databases

ChiTaRSiPik3ca. mouse.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiD3YY41. baseline and differential.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YY41_MOUSE
AccessioniPrimary (citable) accession number: D3YY41
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.