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Protein
Submitted name:

SHC-transforming protein 1

Gene

Shc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: MGI
  • activation of MAPK activity Source: MGI
  • angiogenesis Source: MGI
  • epidermal growth factor receptor signaling pathway Source: MGI
  • heart development Source: MGI
  • insulin receptor signaling pathway Source: GO_Central
  • MAPK cascade Source: MGI
  • regulation of cell proliferation Source: MGI
  • single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SHC-transforming protein 1Imported
Gene namesi
Name:Shc1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:98296. Shc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3YXZ9.

Expressioni

Gene expression databases

BgeeiD3YXZ9.
ExpressionAtlasiD3YXZ9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3YXZ9.
SMRiD3YXZ9. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018860.
HOGENOMiHOG000202186.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
[Graphical view]
PRINTSiPR00629. SHCPIDOMAIN.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3YXZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV
60 70 80 90 100
SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK
110
IIANHHMQSI SFASGGDP
Length:118
Mass (Da):12,881
Last modified:April 20, 2010 - v1
Checksum:i3FA288A8462E968A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei118 – 1181Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC171273 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000154791; ENSMUSP00000123635; ENSMUSG00000042626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC171273 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD3YXZ9.
SMRiD3YXZ9. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD3YXZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154791; ENSMUSP00000123635; ENSMUSG00000042626.

Organism-specific databases

MGIiMGI:98296. Shc1.

Phylogenomic databases

GeneTreeiENSGT00390000018860.
HOGENOMiHOG000202186.

Miscellaneous databases

ChiTaRSiShc1. mouse.
NextBioi35549434.
SOURCEiSearch...

Gene expression databases

BgeeiD3YXZ9.
ExpressionAtlasiD3YXZ9. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
[Graphical view]
PRINTSiPR00629. SHCPIDOMAIN.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD3YXZ9_MOUSE
AccessioniPrimary (citable) accession number: D3YXZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.