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Protein
Submitted name:

SHC-transforming protein 1

Gene

Shc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: MGI
  • activation of MAPK activity Source: MGI
  • angiogenesis Source: MGI
  • epidermal growth factor receptor signaling pathway Source: MGI
  • heart development Source: MGI
  • insulin receptor signaling pathway Source: GO_Central
  • MAPK cascade Source: MGI
  • regulation of cell proliferation Source: MGI
  • single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SHC-transforming protein 1Imported
Gene namesi
Name:Shc1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:98296. Shc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3YXZ9.

Expressioni

Gene expression databases

BgeeiD3YXZ9.
ExpressionAtlasiD3YXZ9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3YXZ9.
SMRiD3YXZ9. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018860.
HOGENOMiHOG000202186.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
[Graphical view]
PRINTSiPR00629. SHCPIDOMAIN.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3YXZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV
60 70 80 90 100
SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK
110
IIANHHMQSI SFASGGDP
Length:118
Mass (Da):12,881
Last modified:April 20, 2010 - v1
Checksum:i3FA288A8462E968A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei118 – 1181Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC171273 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000154791; ENSMUSP00000123635; ENSMUSG00000042626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC171273 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD3YXZ9.
SMRiD3YXZ9. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD3YXZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154791; ENSMUSP00000123635; ENSMUSG00000042626.

Organism-specific databases

MGIiMGI:98296. Shc1.

Phylogenomic databases

GeneTreeiENSGT00390000018860.
HOGENOMiHOG000202186.

Miscellaneous databases

ChiTaRSiShc1. mouse.
NextBioi35549434.
SOURCEiSearch...

Gene expression databases

BgeeiD3YXZ9.
ExpressionAtlasiD3YXZ9. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
[Graphical view]
PRINTSiPR00629. SHCPIDOMAIN.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YXZ9_MOUSE
AccessioniPrimary (citable) accession number: D3YXZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 24, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.