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Protein
Submitted name:

N-lysine methyltransferase KMT5A

Gene

Setd8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2299718. Condensation of Prophase Chromosomes.
R-MMU-3214841. PKMTs methylate histone lysines.
R-MMU-6804760. Regulation of TP53 Activity through Methylation.

Names & Taxonomyi

Protein namesi
Submitted name:
N-lysine methyltransferase KMT5AImported
Gene namesi
Name:Setd8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915206. Setd8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiD3YXI6.
PRIDEiD3YXI6.

Expressioni

Gene expression databases

BgeeiD3YXI6.
ExpressionAtlasiD3YXI6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052953.

Structurei

3D structure databases

ProteinModelPortaliD3YXI6.
SMRiD3YXI6. Positions 204-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 349122SETInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1085. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00410000025501.
HOGENOMiHOG000020818.
KOiK11428.
PhylomeDBiD3YXI6.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YXI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEAGAVGRR RPFPGAPRRR WWRRQQQQQR RRQRWWPGRG EGEGAGRAAM
60 70 80 90 100
GLAGLQENVF AGQSKIYAYM SPNKCSAMRS PLQEENSVAH HEVKCPGKPL
110 120 130 140 150
AGIYRKREEK RNTGNVIRSA VKSDEQKSKD TRRGPLAPFP NQKSEAAEPP
160 170 180 190 200
KTPPPSCDST NVAVAKQALK KSLKGKQAPR KKSQGKTQQN RKLTDFYPVR
210 220 230 240 250
RSSRKSKAEL QSEERKKIDE LIESGKEEGM KIDLIDGKGR GVIATKQFSR
260 270 280 290 300
GDFVVEYHGD LIEITDAKKR EALYAQDPST GCYMYYFQYL SKTYCVDATQ
310 320 330 340 350
ETNRLGRLIN HSKCGNCQTK LHDIDGVPHL ILIASRDIAA GEELLYDYGD
360
RSKASIEAYP WLKH
Length:364
Mass (Da):41,108
Last modified:April 20, 2010 - v1
Checksum:iB32015343E91CA39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127339 Genomic DNA. No translation available.
RefSeqiNP_001297652.1. NM_001310723.1.
UniGeneiMm.137966.
Mm.472072.

Genome annotation databases

EnsembliENSMUST00000100709; ENSMUSP00000098275; ENSMUSG00000049327.
GeneIDi67956.
KEGGimmu:67956.
UCSCiuc008zpw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127339 Genomic DNA. No translation available.
RefSeqiNP_001297652.1. NM_001310723.1.
UniGeneiMm.137966.
Mm.472072.

3D structure databases

ProteinModelPortaliD3YXI6.
SMRiD3YXI6. Positions 204-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052953.

Proteomic databases

PaxDbiD3YXI6.
PRIDEiD3YXI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100709; ENSMUSP00000098275; ENSMUSG00000049327.
GeneIDi67956.
KEGGimmu:67956.
UCSCiuc008zpw.1. mouse.

Organism-specific databases

CTDi67956.
MGIiMGI:1915206. Setd8.

Phylogenomic databases

eggNOGiKOG1085. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00410000025501.
HOGENOMiHOG000020818.
KOiK11428.
PhylomeDBiD3YXI6.

Enzyme and pathway databases

ReactomeiR-MMU-2299718. Condensation of Prophase Chromosomes.
R-MMU-3214841. PKMTs methylate histone lysines.
R-MMU-6804760. Regulation of TP53 Activity through Methylation.

Miscellaneous databases

ChiTaRSiSetd8. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiD3YXI6.
ExpressionAtlasiD3YXI6. baseline and differential.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YXI6_MOUSE
AccessioniPrimary (citable) accession number: D3YXI6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.