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Protein

Histone-lysine N-methyltransferase

Gene

Kmt5a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei283S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-6804760 Regulation of TP53 Activity through Methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:Kmt5aImported
Synonyms:Setd8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915206 Kmt5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiD3YXI6

Expressioni

Gene expression databases

BgeeiENSMUSG00000049327
ExpressionAtlasiD3YXI6 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliD3YXI6
SMRiD3YXI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 349SETInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 240S-adenosyl-L-methionine bindingUniRule annotation3
Regioni310 – 311S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1085 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00410000025501
HOGENOMiHOG000020818
OrthoDBiEOG091G0UBI
PhylomeDBiD3YXI6

Family and domain databases

InterProiView protein in InterPro
IPR016858 Hist_H4-K20_MeTrfase
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
PIRSFiPIRSF027717 Histone_H4-K20_mtfrase, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51571 SAM_MT43_PR_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

D3YXI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEAGAVGRR RPFPGAPRRR WWRRQQQQQR RRQRWWPGRG EGEGAGRAAM
60 70 80 90 100
GLAGLQENVF AGQSKIYAYM SPNKCSAMRS PLQEENSVAH HEVKCPGKPL
110 120 130 140 150
AGIYRKREEK RNTGNVIRSA VKSDEQKSKD TRRGPLAPFP NQKSEAAEPP
160 170 180 190 200
KTPPPSCDST NVAVAKQALK KSLKGKQAPR KKSQGKTQQN RKLTDFYPVR
210 220 230 240 250
RSSRKSKAEL QSEERKKIDE LIESGKEEGM KIDLIDGKGR GVIATKQFSR
260 270 280 290 300
GDFVVEYHGD LIEITDAKKR EALYAQDPST GCYMYYFQYL SKTYCVDATQ
310 320 330 340 350
ETNRLGRLIN HSKCGNCQTK LHDIDGVPHL ILIASRDIAA GEELLYDYGD
360
RSKASIEAYP WLKH
Length:364
Mass (Da):41,108
Last modified:April 20, 2010 - v1
Checksum:iB32015343E91CA39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127339 Genomic DNA No translation available.
RefSeqiNP_001297652.1, NM_001310723.1
UniGeneiMm.137966
Mm.472072

Genome annotation databases

EnsembliENSMUST00000100709; ENSMUSP00000098275; ENSMUSG00000049327
GeneIDi67956
UCSCiuc008zpw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiD3YXI6_MOUSE
AccessioniPrimary (citable) accession number: D3YXI6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health