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D3YWU5

- D3YWU5_MOUSE

UniProt

D3YWU5 - D3YWU5_MOUSE

Protein
Submitted name:

Insulin-2

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. ER overload response Source: MGI
    4. glucose metabolic process Source: MGI
    5. glucose transport Source: MGI
    6. insulin receptor signaling pathway Source: MGI
    7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
    8. lipid catabolic process Source: MGI
    9. myoblast fusion Source: MGI
    10. myotube differentiation Source: MGI
    11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    12. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
    13. regulation of gene expression Source: MGI
    14. regulation of phosphorylation Source: MGI
    15. regulation of protein binding Source: MGI

    Keywords - Molecular functioni

    HormoneSAAS annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Insulin-2Imported
    Gene namesi
    Name:Ins2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:96573. Ins2.

    Subcellular locationi

    Secreted SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular region Source: InterPro
    3. nucleus Source: MGI
    4. secretory granule Source: MGI
    5. small nucleolar ribonucleoprotein complex Source: MGI

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiD3YWU5.

    Expressioni

    Gene expression databases

    ArrayExpressiD3YWU5.
    BgeeiD3YWU5.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3YWU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000015440.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR004825. Insulin.
    IPR016179. Insulin-like.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00277. INSULIN.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    D3YWU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY   50
    TPMSRREVED PQAGELLQLD 70
    Length:70
    Mass (Da):8,151
    Last modified:May 14, 2014 - v2
    Checksum:i328F1449986DB475
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei70 – 701Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013548 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000125933; ENSMUSP00000115147; ENSMUSG00000000215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013548 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D3YWU5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi D3YWU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000125933 ; ENSMUSP00000115147 ; ENSMUSG00000000215 .

    Organism-specific databases

    MGIi MGI:96573. Ins2.

    Phylogenomic databases

    GeneTreei ENSGT00390000015440.

    Miscellaneous databases

    ChiTaRSi Ins2. mouse.
    NextBioi 35549176.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D3YWU5.
    Bgeei D3YWU5.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR004825. Insulin.
    IPR016179. Insulin-like.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00277. INSULIN.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiD3YWU5_MOUSE
    AccessioniPrimary (citable) accession number: D3YWU5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 37 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3