ID   D3YWU4_MOUSE            Unreviewed;       239 AA.
AC   D3YWU4;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=Protein spinster homolog 1 {ECO:0000256|ARBA:ARBA00039482};
DE   AltName: Full=Spns1 {ECO:0000256|ARBA:ARBA00041462};
DE   Flags: Fragment;
GN   Name=Spns1 {ECO:0000313|Ensembl:ENSMUSP00000115152.2,
GN   ECO:0000313|MGI:MGI:1920908};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115152.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000115152.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115152.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000115152.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115152.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)
CC         = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in);
CC         Xref=Rhea:RHEA:74447, ChEBI:CHEBI:15378, ChEBI:CHEBI:77287;
CC         Evidence={ECO:0000256|ARBA:ARBA00036769};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) +
CC         H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) +
CC         H(+)(in); Xref=Rhea:RHEA:74455, ChEBI:CHEBI:15378, ChEBI:CHEBI:77288;
CC         Evidence={ECO:0000256|ARBA:ARBA00036994};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1-
CC         acyl-sn-glycero-3-phosphocholine(in) + H(+)(in);
CC         Xref=Rhea:RHEA:74435, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168;
CC         Evidence={ECO:0000256|ARBA:ARBA00035932};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a
CC         1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in);
CC         Xref=Rhea:RHEA:74439, ChEBI:CHEBI:15378, ChEBI:CHEBI:64381;
CC         Evidence={ECO:0000256|ARBA:ARBA00036238};
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster
CC       (TC 2.A.1.49) family. {ECO:0000256|ARBA:ARBA00024338}.
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DR   AlphaFoldDB; D3YWU4; -.
DR   SMR; D3YWU4; -.
DR   jPOST; D3YWU4; -.
DR   MaxQB; D3YWU4; -.
DR   ProteomicsDB; 370129; -.
DR   Antibodypedia; 26665; 85 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000150476.3; ENSMUSP00000115152.2; ENSMUSG00000030741.16.
DR   AGR; MGI:1920908; -.
DR   MGI; MGI:1920908; Spns1.
DR   VEuPathDB; HostDB:ENSMUSG00000030741; -.
DR   GeneTree; ENSGT00390000005976; -.
DR   HOGENOM; CLU_071210_0_0_1; -.
DR   OMA; TYYKEHF; -.
DR   ChiTaRS; Spns1; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000030741; Expressed in yolk sac and 228 other cell types or tissues.
DR   ExpressionAtlas; D3YWU4; baseline and differential.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd17328; MFS_spinster_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044770; MFS_spinster-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23505:SF13; PROTEIN SPINSTER HOMOLOG 1; 1.
DR   PANTHER; PTHR23505; SPINSTER; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:D3YWU4,
KW   ECO:0007829|MaxQB:D3YWU4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        27..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        135..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        158..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..239
FT                   /note="Major facilitator superfamily (MFS) profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
FT   NON_TER         239
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000115152.2"
SQ   SEQUENCE   239 AA;  26103 MW;  7895BBE76A106155 CRC64;
     MGNPKSGELE VPDCEGLQRI TGLSRGHSTL IVVVLCYINL LNYMDRFTVA GVLTDIEQFF
     NIGDGSTGLI QTVFISSYMV LAPVFGYLGD RYNRKYLMCG GIAFWSLVTL GSSFIPREHF
     WLLLLTRGLV GVGEASYSTI APTLIADLFV ADQRSRMLSI FYFAIPVGSG LGYIAGSKVK
     DVAGDWHWAL RVTPGLGVLA VLLLFLVVQE PPRGAVERHS GSPPLSPTSW WADLKALAR
//