Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease

Gene

Rnaseh2a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: MGI

GO - Biological processi

  1. mismatch repair Source: MGI
  2. RNA catabolic process Source: MGI
  3. RNA phosphodiester bond hydrolysis, endonucleolytic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
RibonucleaseUniRule annotation (EC:3.1.26.-UniRule annotation)
Gene namesi
Name:Rnaseh2aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916974. Rnaseh2a.

Subcellular locationi

GO - Cellular componenti

  1. ribonuclease H2 complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3YWG3.

Expressioni

Gene expression databases

BgeeiD3YWG3.
ExpressionAtlasiD3YWG3. baseline and differential.

Structurei

3D structure databases

SMRiD3YWG3. Positions 1-54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010768.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Fragment.

D3YWG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSELERDN TGRCRLSSPV PAVCLKEPCV LGVDEAGRGP VLGPMVYAIC

YCPL
Length:54
Mass (Da):5,795
Last modified:April 20, 2010 - v1
Checksum:iE3EF570F77767B76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei54 – 541Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163703 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000140561; ENSMUSP00000118442; ENSMUSG00000052926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163703 Genomic DNA. No translation available.

3D structure databases

SMRiD3YWG3. Positions 1-54.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD3YWG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000140561; ENSMUSP00000118442; ENSMUSG00000052926.

Organism-specific databases

MGIiMGI:1916974. Rnaseh2a.

Phylogenomic databases

GeneTreeiENSGT00390000010768.

Miscellaneous databases

ChiTaRSiRnaseh2a. mouse.
NextBioi35549089.
SOURCEiSearch...

Gene expression databases

BgeeiD3YWG3.
ExpressionAtlasiD3YWG3. baseline and differential.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YWG3_MOUSE
AccessioniPrimary (citable) accession number: D3YWG3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.