Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional activator MN1

Gene

Mn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418). Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418). Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590). Necessary for normal development of the membranous bones of the skull (PubMed:15870292). May play a role in tumor suppression (By similarity).By similarity3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator MN1Curated
Gene namesi
Name:Mn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1261813. Mn1.

Pathology & Biotechi

Disruption phenotypei

Lethality occurs at or shortly after birth, associated with cleft secondary palate (PubMed:15870292). Skulls at late embryonic stages show multiple abnormalities including complete loss of alisphenoid, squamosal and vomer bones, and poorly developed presphenoid and basisphenoid bones (PubMed:15870292). Other parts of the skeleton are not affected (PubMed:15870292). Early palate development is normal but later the palatal shelves fail to grow and elevate towards the midline, associated with both impaired cell division and apoptosis (PubMed:18948418).2 Publications

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12971297Transcriptional activator MN1PRO_0000435338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei932 – 9321PhosphoserineBy similarity
Modified residuei936 – 9361PhosphoserineBy similarity
Modified residuei988 – 9881PhosphoserineBy similarity
Modified residuei1062 – 10621PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiD3YWE6.
PRIDEiD3YWE6.

PTM databases

iPTMnetiD3YWE6.
PhosphoSiteiD3YWE6.

Expressioni

Tissue specificityi

Detected in brain, heart, tibia, and calvarial osteoclasts.1 Publication

Developmental stagei

Detected in the midbrain, hindbrain and craniofacial mesenchyme at E9.5. At E10.5 and E11.5, strong expression is detected in the brain, frontonasal processes, maxillary processes, mandibular processes, the second brachial arch, and also in somites and limb buds. In the developing palatal shelves from E12.5-E14.5, shows graded expression with highest levels in the posterior and middle regions and very low levels in the anterior region.1 Publication

Inductioni

By calcitrol (1,25-dihydroxyvitamin D3).1 Publication

Gene expression databases

BgeeiENSMUSG00000070576.
GenevisibleiD3YWE6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092034.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi71 – 14474Gly/His-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi292 – 506215Pro-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi509 – 56456Gln-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi620 – 775156Pro-richPROSITE-ProRule annotationAdd
BLAST

Phylogenomic databases

GeneTreeiENSGT00390000001777.
HOGENOMiHOG000088640.
InParanoidiD3YWE6.
OMAiLSPNYNM.
OrthoDBiEOG091G01PB.
PhylomeDBiD3YWE6.
TreeFamiTF331780.

Sequencei

Sequence statusi: Complete.

D3YWE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGLDQFEPQ INSRHAGQGE GNFNEAGLSM NAHFKAPAFH AGPPTGPVDP
60 70 80 90 100
AISALGEPPI LGLNMEPYGF HARSHSELHA GGLQAQPVHG FFGGQQPHHS
110 120 130 140 150
HPGGHHPHQH HPHFGGNFGG PDPGASCLHG GRLLGYGGAA GGLGSQPPFA
160 170 180 190 200
ESYEHMAESQ GPEGFGPQRP GNLPDFHSSG TSGHAVPAPC LPLDQSPNRA
210 220 230 240 250
ASFHGLSASS GSDSHSLEPR RVTNQGAVDS LEYNYPSEPP SGHFDMFSPS
260 270 280 290 300
DSEGQLPHYA AGRQVPGGAF PGASAMPRAS GMVGLSKMHS QPPQPPPQQQ
310 320 330 340 350
QPQHGVFFER FGGARKMPVG LEPAVGSRHP LMQPPQQAPP PPQQPPPQQQ
360 370 380 390 400
PPPPGLLVRQ NSCPPALPRP QQGEAGTPSG GLQDGGPMLP SQHAQFEYPI
410 420 430 440 450
HRLENRSMHP YSEPVFSMQH PPPQQAPNQR LQHFDAPPYM NVAKRPRFDF
460 470 480 490 500
PGSAGVDRCA SWNGSMHNGT LDNQLSPSAY PGLPGEFTPP VPDSFSSGPP
510 520 530 540 550
LQHPGPDHQS LQQQQQQQQQ QQQQQQQQQQ QQQQQQQRQN AALMIKQMAS
560 570 580 590 600
RNQQQRLRQP NLAQLGHPGD VGQGGLVHGG SVGGLAQTNF EREGGSAGAG
610 620 630 640 650
RLSGFEQQAP HLAQESAWFP GPHPPGDLLP RRMGGAGLPT DCGPHDPALA
660 670 680 690 700
PPPAPGGSGV LFRGSLQEPL RMPGEGHVPA LASPGLQFGG SLAGLGQLQS
710 720 730 740 750
PGAGVGLPNA PSERRPPPPD FPAPALGGQP GFPFGSGSRQ ATPHSAPGVN
760 770 780 790 800
SPPSAGSGSS GAGGGAYPPQ PDFQPSQRNS ASKLGALSLG SFNKPSSKDN
810 820 830 840 850
LFGQSCLAAL STACQNMIAS LGAPNLNVTF NKKNPPEGKR KLSQNEPDSA
860 870 880 890 900
VAAGNPGSDY FPGGTTPGAP GPGGPSGTSG GGSKASGPPN PPIQGDSTSL
910 920 930 940 950
SPNYTLESTS GNDGKPVPGG SGRGRGRRKR DSGHVSPGTF FDKYSTAPDS
960 970 980 990 1000
GGAPGVSPGQ QQAPGSAAGG SSVNEARGPT PHEKALTSPS WGKGAELLLG
1010 1020 1030 1040 1050
DQPDLMASLD STAKSDGSSP HVGEFASDEV STSYANEDEV SSSSDNTTAL
1060 1070 1080 1090 1100
AKASRSPLVT SSPKLPPRGV GAGEHTPKAS ALGLGILSTS TSTPDSYGGG
1110 1120 1130 1140 1150
VGTGHPGTPG LEQVRTPTSS SGAQPPDEIH PLEILQAQIQ LQRQQFSISE
1160 1170 1180 1190 1200
DQPLGLKGSK KAECAVGASG AQNGDSELGS CCSEAVKSAM STIDLDSLMA
1210 1220 1230 1240 1250
EHSTTWYMPP DKALVDGGDE DKTLAPWEKA KSQNPNNKEA HDHPTNKASA
1260 1270 1280 1290
TQPGSHLQCL TVHCTDGDPK ARTSVPTWRS LHSDISNRFG TFVAALT
Length:1,297
Mass (Da):134,072
Last modified:April 20, 2010 - v1
Checksum:i41130654703FF053
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122226 Genomic DNA. No translation available.
AC124749 Genomic DNA. No translation available.
CCDSiCCDS39214.1.
RefSeqiNP_001074704.1. NM_001081235.1.
UniGeneiMm.332576.

Genome annotation databases

EnsembliENSMUST00000094463; ENSMUSP00000092034; ENSMUSG00000070576.
GeneIDi433938.
KEGGimmu:433938.
UCSCiuc008yse.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122226 Genomic DNA. No translation available.
AC124749 Genomic DNA. No translation available.
CCDSiCCDS39214.1.
RefSeqiNP_001074704.1. NM_001081235.1.
UniGeneiMm.332576.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092034.

PTM databases

iPTMnetiD3YWE6.
PhosphoSiteiD3YWE6.

Proteomic databases

MaxQBiD3YWE6.
PRIDEiD3YWE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094463; ENSMUSP00000092034; ENSMUSG00000070576.
GeneIDi433938.
KEGGimmu:433938.
UCSCiuc008yse.1. mouse.

Organism-specific databases

CTDi4330.
MGIiMGI:1261813. Mn1.

Phylogenomic databases

GeneTreeiENSGT00390000001777.
HOGENOMiHOG000088640.
InParanoidiD3YWE6.
OMAiLSPNYNM.
OrthoDBiEOG091G01PB.
PhylomeDBiD3YWE6.
TreeFamiTF331780.

Miscellaneous databases

PROiD3YWE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070576.
GenevisibleiD3YWE6. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMN1_MOUSE
AccessioniPrimary (citable) accession number: D3YWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.