Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor

Gene

Fgf3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  1. fibroblast growth factor receptor signaling pathway Source: MGI
  2. negative regulation of cardiac muscle tissue development Source: MGI
  3. organ induction Source: MGI
  4. otic vesicle formation Source: MGI
  5. positive regulation of cell proliferation Source: MGI
  6. post-anal tail morphogenesis Source: MGI
  7. semicircular canal morphogenesis Source: MGI
  8. thymus development Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_289551. FGFR1b ligand binding and activation.
REACT_297015. FGFR2b ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:Fgf3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95517. Fgf3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: InterPro
  3. Golgi apparatus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717UniRule annotationAdd
BLAST
Chaini18 – 156139Fibroblast growth factorUniRule annotationPRO_5001341142Add
BLAST

Expressioni

Gene expression databases

BgeeiD3YWD4.
ExpressionAtlasiD3YWD4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3YWD4.
SMRiD3YWD4. Positions 35-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
OrthoDBiEOG7992S1.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028232. FGF3.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF26. PTHR11486:SF26. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3YWD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLIWLLLLS LLEPSWPTTG PGTRLRRDAG GRGGVYEHLG GAPRRRKLYC
60 70 80 90 100
ATKYHLQLHP SGRVNGSLEN SAYSILEITA VEVGVVAIKG LFSGRYLAMN
110 120 130 140 150
KRGRLYASDH YNAECEFVER IHELGYNTYA SRLYRTGSSG PGAQRQPGAQ

RPWYVS
Length:156
Mass (Da):17,340
Last modified:April 20, 2010 - v1
Checksum:i49D89E640C3434B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei156 – 1561Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149593 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000155320; ENSMUSP00000115205; ENSMUSG00000031074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149593 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD3YWD4.
SMRiD3YWD4. Positions 35-152.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000155320; ENSMUSP00000115205; ENSMUSG00000031074.

Organism-specific databases

MGIiMGI:95517. Fgf3.

Phylogenomic databases

GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
OrthoDBiEOG7992S1.

Enzyme and pathway databases

ReactomeiREACT_289551. FGFR1b ligand binding and activation.
REACT_297015. FGFR2b ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Miscellaneous databases

NextBioi35549074.
SOURCEiSearch...

Gene expression databases

BgeeiD3YWD4.
ExpressionAtlasiD3YWD4. baseline and differential.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028232. FGF3.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF26. PTHR11486:SF26. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YWD4_MOUSE
AccessioniPrimary (citable) accession number: D3YWD4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 1, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.