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D3YWD4

- D3YWD4_MOUSE

UniProt

D3YWD4 - D3YWD4_MOUSE

Protein

Fibroblast growth factor

Gene

Fgf3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    GO - Biological processi

    1. fibroblast growth factor receptor signaling pathway Source: MGI
    2. negative regulation of cardiac muscle tissue development Source: Ensembl
    3. organ induction Source: MGI
    4. otic vesicle formation Source: MGI
    5. positive regulation of cell proliferation Source: MGI
    6. post-anal tail morphogenesis Source: MGI
    7. semicircular canal morphogenesis Source: MGI
    8. thymus development Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_220836. FGFR1b ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factorUniRule annotation
    Short name:
    FGFUniRule annotation
    Gene namesi
    Name:Fgf3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95517. Fgf3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular region Source: InterPro
    3. Golgi apparatus Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiD3YWD4.
    BgeeiD3YWD4.

    Structurei

    3D structure databases

    ProteinModelPortaliD3YWD4.
    SMRiD3YWD4. Positions 35-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heparin-binding growth factors family.UniRule annotation

    Keywords - Domaini

    SignalUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110261.
    HOGENOMiHOG000236341.
    OrthoDBiEOG7992S1.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028232. FGF3.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF26. PTHR11486:SF26. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D3YWD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLIWLLLLS LLEPSWPTTG PGTRLRRDAG GRGGVYEHLG GAPRRRKLYC    50
    ATKYHLQLHP SGRVNGSLEN SAYSILEITA VEVGVVAIKG LFSGRYLAMN 100
    KRGRLYASDH YNAECEFVER IHELGYNTYA SRLYRTGSSG PGAQRQPGAQ 150
    RPWYVS 156
    Length:156
    Mass (Da):17,340
    Last modified:April 20, 2010 - v1
    Checksum:i49D89E640C3434B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei156 – 1561Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149593 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000155320; ENSMUSP00000115205; ENSMUSG00000031074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149593 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D3YWD4.
    SMRi D3YWD4. Positions 35-152.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000155320 ; ENSMUSP00000115205 ; ENSMUSG00000031074 .

    Organism-specific databases

    MGIi MGI:95517. Fgf3.

    Phylogenomic databases

    GeneTreei ENSGT00730000110261.
    HOGENOMi HOG000236341.
    OrthoDBi EOG7992S1.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_220836. FGFR1b ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 35549074.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D3YWD4.
    Bgeei D3YWD4.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028232. FGF3.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF26. PTHR11486:SF26. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiD3YWD4_MOUSE
    AccessioniPrimary (citable) accession number: D3YWD4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3