ID   D3YWD1_MOUSE            Unreviewed;      1703 AA.
AC   D3YWD1;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 2.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Collagen, type VI, alpha 3 {ECO:0000313|Ensembl:ENSMUSP00000115210.3};
DE   Flags: Fragment;
GN   Name=Col6a3 {ECO:0000313|Ensembl:ENSMUSP00000115210.3,
GN   ECO:0000313|MGI:MGI:88461};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115210.3, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000115210.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115210.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000115210.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115210.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   SASBDB; D3YWD1; -.
DR   SMR; D3YWD1; -.
DR   jPOST; D3YWD1; -.
DR   PeptideAtlas; D3YWD1; -.
DR   ProteomicsDB; 345218; -.
DR   Antibodypedia; 1395; 99 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000130846.9; ENSMUSP00000115210.3; ENSMUSG00000048126.17.
DR   AGR; MGI:88461; -.
DR   MGI; MGI:88461; Col6a3.
DR   VEuPathDB; HostDB:ENSMUSG00000048126; -.
DR   GeneTree; ENSGT00940000156462; -.
DR   HOGENOM; CLU_001732_0_0_1; -.
DR   OMA; KGGRQAN; -.
DR   ChiTaRS; Col6a3; mouse.
DR   Proteomes; UP000000589; Chromosome 1.
DR   Bgee; ENSMUSG00000048126; Expressed in umbilical cord and 204 other cell types or tissues.
DR   ExpressionAtlas; D3YWD1; baseline and differential.
DR   GO; GO:0005581; C:collagen trimer; IDA:MGI.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR   GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0042383; C:sarcolemma; IDA:MGI.
DR   GO; GO:0051402; P:neuron apoptotic process; IDA:MGI.
DR   GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IDA:MGI.
DR   GO; GO:0009411; P:response to UV; IDA:MGI.
DR   CDD; cd01481; vWA_collagen_alpha3-VI-like; 1.
DR   CDD; cd01450; vWFA_subfamily_ECM; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR   InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR   PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00092; VWA; 9.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00327; VWA; 8.
DR   SUPFAM; SSF53300; vWA-like; 9.
DR   PROSITE; PS50234; VWFA; 9.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:D3YWD1,
KW   ECO:0007829|MaxQB:D3YWD1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..1703
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003052344"
FT   DOMAIN          38..212
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          241..414
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          444..619
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          638..811
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          836..1008
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          1026..1202
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          1230..1401
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          1433..1606
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          1636..1703
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1610..1630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1703
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000115210.3"
SQ   SEQUENCE   1703 AA;  185729 MW;  B12CA8944C16FB66 CRC64;
     MRKHRHLPLV AVFSLLLSGI ATTHAQQHGD VKNGAAADIV FLVDSSWSAG KDRFLLVQEF
     LSDVVESLAV GDNDFHFALV RLNGNPHTEF LLNTYHSKQE VLSHIVNMSY IGGSNQTGKG
     LEYVIHSHLT EASGSRAADG VPQVIIVLTD GQSEDGFALP SAELKSADVN VFAVGVEGAD
     ERALGEVASE PLSMHVFNLE NVTSLHGLVG NLVSCIHSSV NPERAGDKES LKDITAQDSA
     DIIFLIDGSQ NTGNANFDVI RDFLVNVLER LSVGNQQVQV GVVQYSEEPI TMFSLNSYPS
     KAAVLDAVKG LSLVGGESAN IGQALDFVVE NHFTRAGGSR VEEGVPQVLV LISAGPSSDE
     IRDSVVALKQ ASVFSFGLGA QAASRAELQH IATDDSLVFT VPEFRSFGDL QEQILPYLVG
     VAQRHIVLQP PAIVTQVMEV NKRDIVFLVD GSSSLGPSNF NAIRDFVTRV IQRLEIGQDL
     VQVSVAQYAD TVKPEFYLNS YTNKRDAITA VRKMRALNGS ALYTGSSLDF VRNNLFTSSA
     GHRAAEGVPK LLVLITGGKS LDEVSQPAQE LKRGSIMALA VGSKAADEDE LKEIAFDSSL
     VFIPAEFRPA PLQNMLPSLM APLRTLTGTT EVHVNKRDII FLLDGSDNVG KNNFPYVRDF
     VTNLVNSLDV GSDNIRVGLV QFSDTPVTEF SLDTYQTKSE LLAHLRRLQL KGGSGLNAGS
     ALSYIHANHF TEAGGSRTRE HVPQLLLLLM AGPSEDAYLQ AANALVRSGV LTFCVGTNRA
     DKAELEHIAF NPSLVYLMDD FRSLPSLPQQ LIQPLTTYVS GGVQEVPLSQ PESKRDILFL
     FDGSVNVLGQ FPAVRDFLYR IIEELDVKPD GTRVAIAQFS DDVRLESRFS EHQTKAEILN
     LVKKMKLKTG KALNLGYALD YALRNIFVRS AGSRIEDNVQ QFLVLLVAGR SSDAVAGPAS
     SLKQRGVVPF IFQAKNANPS ELEQIVLSPA FILAAESLPK IGDLQSQIVS LLKAEQGSGP
     VSGEKDVVFL IDGSEGVRSG FPLLKDFVQR VVESLDVGPD RVRVALVQYS DRTRPEFYLN
     SHMDQQGVIS AIRRLTLLGG PTPNTGAALE FVLRNILTSS TGSRIAEGVP QLLIVLTAEP
     SGDDVRGPSV VLKQGGAVPI GIGIGNADIS EMQTISFIPD FAVAIPTFRE LGTIQQVISE
     RVIQLNREEL SSLKPILTPS TGAGVGSKKD VVFLIDGSRN AGPEFQYIRT LIERIVEYLD
     IGFDTTRVAV IQFSEDSKME FPLNAHFSKD EVQNAVRRLR PKGGSQVYIG NALEYVLKNI
     FQRPLGSRIE EGVPQFLVLI SSGKSDDEVD DSAVELKQFG VAPLTIARHT DQEELVKISL
     SPEYVYSVST FRELPRLEQK LLTPITTLTS QQIHQILAST RYPPSVVESD AADIVFLIDS
     SDAVKPDGIA HIRDFVSRIV RRLNIGPSKV RIGVVQFSND VFPEFYLKTH KSQSSVLEAI
     RRLRFKGGSP LNTGRALEFV ARNLFVKSAG SRIEDGVPQH LVLFLGGKSQ DDVARHAQVI
     SSSGIVSLGI GDRNIDRTDL QTITNDPRLV FTVREFRELP NIEERVMLSF GPSGATPQPP
     GVDLPSPSRP EKKKADIVFL LDGSINFRRD SFQEVLRFAS EIVDTVYEDG DSIRVGLVQY
     NSDPTDEFFL RDFSTKRQII DAI
//