Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hepatocyte growth factor receptor

Gene

Met

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-416550. Sema4D mediated inhibition of cell attachment and migration.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6806942. MET Receptor Activation.
R-MMU-6807004. Negative regulation of MET activity.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8851805. MET activates RAS signaling.
R-MMU-8851907. MET activates PI3K/AKT signaling.
R-MMU-8865999. MET activates PTPN11.
R-MMU-8874081. MET activates PTK2 signaling.
R-MMU-8875513. MET interacts with TNS proteins.
R-MMU-8875555. MET activates RAP1 and RAC1.
R-MMU-8875656. MET receptor recycling.
R-MMU-8875791. MET activates STAT3.

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor receptorImported
Gene namesi
Name:MetImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96969. Met.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500305250925 – 169Sequence analysisAdd BLAST145

Proteomic databases

PaxDbiD3YVY2.
PeptideAtlasiD3YVY2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009376.
ExpressionAtlasiD3YVY2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 169SemaInterPro annotationAdd BLAST143

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR031148. Plexin.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3YVY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPTVLAPG ILVLLLSLVQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET
60 70 80 90 100
PIQNVVLHGH HIYLGATNYI YVLNDKDLQK VSEFKTGPVL EHPDCLPCRD
110 120 130 140 150
CSSKANSSGG VWKDNINMAL LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN
160
SADIQSEVHC MFSPEEESG
Length:169
Mass (Da):18,688
Last modified:April 20, 2010 - v1
Checksum:iDD9181920EF51F2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei169Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024950 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000140070; ENSMUSP00000117856; ENSMUSG00000009376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024950 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079324.

Proteomic databases

PaxDbiD3YVY2.
PeptideAtlasiD3YVY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000140070; ENSMUSP00000117856; ENSMUSG00000009376.

Organism-specific databases

MGIiMGI:96969. Met.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.

Enzyme and pathway databases

ReactomeiR-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-416550. Sema4D mediated inhibition of cell attachment and migration.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6806942. MET Receptor Activation.
R-MMU-6807004. Negative regulation of MET activity.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8851805. MET activates RAS signaling.
R-MMU-8851907. MET activates PI3K/AKT signaling.
R-MMU-8865999. MET activates PTPN11.
R-MMU-8874081. MET activates PTK2 signaling.
R-MMU-8875513. MET interacts with TNS proteins.
R-MMU-8875555. MET activates RAP1 and RAC1.
R-MMU-8875656. MET receptor recycling.
R-MMU-8875791. MET activates STAT3.

Miscellaneous databases

ChiTaRSiMet. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009376.
ExpressionAtlasiD3YVY2. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR031148. Plexin.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3YVY2_MOUSE
AccessioniPrimary (citable) accession number: D3YVY2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.