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Protein
Submitted name:

Hepatocyte growth factor receptor

Gene

Met

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-416550 Sema4D mediated inhibition of cell attachment and migration
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6806942 MET Receptor Activation
R-MMU-6807004 Negative regulation of MET activity
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8851805 MET activates RAS signaling
R-MMU-8851907 MET activates PI3K/AKT signaling
R-MMU-8865999 MET activates PTPN11
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8875513 MET interacts with TNS proteins
R-MMU-8875555 MET activates RAP1 and RAC1
R-MMU-8875656 MET receptor recycling
R-MMU-8875791 MET activates STAT3
R-MMU-9032759 NTRK2 activates RAC1

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor receptorImported
Gene namesi
Name:MetImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96969 Met

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500305250925 – 169Sequence analysisAdd BLAST145

Proteomic databases

MaxQBiD3YVY2
PeptideAtlasiD3YVY2
PRIDEiD3YVY2

Expressioni

Gene expression databases

BgeeiENSMUSG00000009376
ExpressionAtlasiD3YVY2 baseline and differential

Structurei

3D structure databases

SMRiD3YVY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 169SemaInterPro annotationAdd BLAST143

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
KOG3610 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00810000125384

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF01403 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Fragment.

D3YVY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPTVLAPG ILVLLLSLVQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET
60 70 80 90 100
PIQNVVLHGH HIYLGATNYI YVLNDKDLQK VSEFKTGPVL EHPDCLPCRD
110 120 130 140 150
CSSKANSSGG VWKDNINMAL LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN
160
SADIQSEVHC MFSPEEESG
Length:169
Mass (Da):18,688
Last modified:April 20, 2010 - v1
Checksum:iDD9181920EF51F2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei169Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024950 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000140070; ENSMUSP00000117856; ENSMUSG00000009376

Similar proteinsi

Entry informationi

Entry nameiD3YVY2_MOUSE
AccessioniPrimary (citable) accession number: D3YVY2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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