ID   D3YVX9_MOUSE            Unreviewed;       263 AA.
AC   D3YVX9;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   27-MAR-2024, entry version 87.
DE   SubName: Full=Mitogen-activated protein kinase kinase kinase 1 {ECO:0000313|Ensembl:ENSMUSP00000117863.2};
DE   Flags: Fragment;
GN   Name=Map3k1 {ECO:0000313|Ensembl:ENSMUSP00000117863.2,
GN   ECO:0000313|MGI:MGI:1346872};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117863.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000117863.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117863.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000117863.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117863.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; D3YVX9; -.
DR   jPOST; D3YVX9; -.
DR   PeptideAtlas; D3YVX9; -.
DR   ProteomicsDB; 314055; -.
DR   Antibodypedia; 3855; 503 antibodies from 36 providers.
DR   Ensembl; ENSMUST00000145055.2; ENSMUSP00000117863.2; ENSMUSG00000021754.18.
DR   AGR; MGI:1346872; -.
DR   MGI; MGI:1346872; Map3k1.
DR   VEuPathDB; HostDB:ENSMUSG00000021754; -.
DR   GeneTree; ENSGT00940000159154; -.
DR   HOGENOM; CLU_1059792_0_0_1; -.
DR   OMA; HHTRMRR; -.
DR   ChiTaRS; Map3k1; mouse.
DR   Proteomes; UP000000589; Chromosome 13.
DR   Bgee; ENSMUSG00000021754; Expressed in substantia propria of cornea and 236 other cell types or tissues.
DR   ExpressionAtlas; D3YVX9; baseline and differential.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR007527; Znf_SWIM.
DR   InterPro; IPR039903; Zswim2.
DR   PANTHER; PTHR21540:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2; 1.
DR   PANTHER; PTHR21540; RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF04434; SWIM; 1.
DR   PROSITE; PS50966; ZF_SWIM; 1.
PE   1: Evidence at protein level;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00325};
KW   Proteomics identification {ECO:0007829|EPD:D3YVX9,
KW   ECO:0007829|MaxQB:D3YVX9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00325};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00325}.
FT   DOMAIN          175..203
FT                   /note="SWIM-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50966"
FT   REGION          40..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         263
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000117863.2"
SQ   SEQUENCE   263 AA;  29637 MW;  EB698A02CEB177A6 CRC64;
     MENKETLKGL HKMEDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV KPIPIKGDGS
     EMNNLAAEPQ GEGQAGSAAP APKGRRSPSP GSSPSGRSVK PESPGVRRKR VSPVPFQSGR
     ITPPRRAPSP DGFSPYSPEE TSRRVNKVMR ARLYLLQQIG PNSFLIGGDS PDNKYRVFIG
     PQNCSCGRGA FCIHLLFVML RVFQLEPSDP MLWRKTLKNF EVESLFQKYH SRRSSRIKAP
     SRNTIQKFVS RMSNCHTLSS SST
//