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D3YVX9

- D3YVX9_MOUSE

UniProt

D3YVX9 - D3YVX9_MOUSE

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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 1

Gene

Map3k1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. JUN kinase kinase activity Source: MGI
  2. protein kinase activity Source: MGI
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. activation of JUN kinase activity Source: MGI
  2. apoptotic mitochondrial changes Source: MGI
  3. camera-type eye development Source: MGI
  4. cellular response to mechanical stimulus Source: Ensembl
  5. epithelial cell morphogenesis Source: MGI
  6. eyelid development in camera-type eye Source: MGI
  7. JNK cascade Source: MGI
  8. positive regulation of actin filament polymerization Source: MGI
  9. protein phosphorylation Source: GOC
  10. regulation of cell migration Source: MGI
  11. transforming growth factor beta receptor signaling pathway Source: MGI
  12. wound healing Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_188530. FCERI mediated MAPK activation.
REACT_202898. TRAF6 mediated NF-kB activation.
REACT_229712. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_230045. MyD88:Mal cascade initiated on plasma membrane.
REACT_245896. MyD88 cascade initiated on plasma membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 1Imported
Gene namesi
Name:Map3k1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1346872. Map3k1.

PTM / Processingi

Proteomic databases

PRIDEiD3YVX9.

Expressioni

Gene expression databases

BgeeiD3YVX9.
ExpressionAtlasiD3YVX9. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119077.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3YVX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENKETLKGL HKMEDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV
60 70 80 90 100
KPIPIKGDGS EMNNLAAEPQ GEGQAGSAAP APKGRRSPSP GSSPSGRSVK
110 120 130 140 150
PESPGVRRKR VSPVPFQSGR ITPPRRAPSP DGFSPYSPEE TSRRVNKVMR
160 170 180 190 200
ARLYLLQQIG PNSFLIGGDS PDNKYRVFIG PQNCSCGRGA FCIHLLFVML
210 220 230 240 250
RVFQLEPSDP MLWRKTLKNF EVESLFQKYH SRRSSRIKAP SRNTIQKFVS
260
RMSNCHTLSS SSTS
Length:264
Mass (Da):29,724
Last modified:October 29, 2014 - v3
Checksum:i9E9B698A02CEB177
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei264 – 2641Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118704 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000145055; ENSMUSP00000117863; ENSMUSG00000021754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118704 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi D3YVX9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000145055 ; ENSMUSP00000117863 ; ENSMUSG00000021754 .

Organism-specific databases

MGIi MGI:1346872. Map3k1.

Phylogenomic databases

GeneTreei ENSGT00760000119077.

Enzyme and pathway databases

Reactomei REACT_188530. FCERI mediated MAPK activation.
REACT_202898. TRAF6 mediated NF-kB activation.
REACT_229712. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_230045. MyD88:Mal cascade initiated on plasma membrane.
REACT_245896. MyD88 cascade initiated on plasma membrane.

Miscellaneous databases

ChiTaRSi Map3k1. mouse.
NextBioi 35548973.
SOURCEi Search...

Gene expression databases

Bgeei D3YVX9.
ExpressionAtlasi D3YVX9. baseline and differential.

Family and domain databases

InterProi IPR007527. Znf_SWIM.
[Graphical view ]
Pfami PF04434. SWIM. 1 hit.
[Graphical view ]
PROSITEi PS50966. ZF_SWIM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YVX9_MOUSE
AccessioniPrimary (citable) accession number: D3YVX9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: October 29, 2014
Last modified: November 26, 2014
This is version 36 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3