Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 1

Gene

Map3k1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of JNKK activity Source: GOC
  • activation of JUN kinase activity Source: MGI
  • apoptotic mitochondrial changes Source: MGI
  • camera-type eye development Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • epithelial cell morphogenesis Source: MGI
  • eyelid development in camera-type eye Source: MGI
  • JNK cascade Source: MGI
  • positive regulation of actin filament polymerization Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell migration Source: MGI
  • regulation of mitotic cell cycle Source: GO_Central
  • transforming growth factor beta receptor signaling pathway Source: MGI
  • wound healing Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_271614. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_273973. MyD88 cascade initiated on plasma membrane.
REACT_275137. TRAF6 mediated NF-kB activation.
REACT_309099. MyD88:Mal cascade initiated on plasma membrane.
REACT_314186. FCERI mediated MAPK activation.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 1Imported
Gene namesi
Name:Map3k1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1346872. Map3k1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3YVX9.

Expressioni

Gene expression databases

BgeeiD3YVX9.
ExpressionAtlasiD3YVX9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104890.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00790000122958.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3YVX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKETLKGL HKMEDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV
60 70 80 90 100
KPIPIKGDGS EMNNLAAEPQ GEGQAGSAAP APKGRRSPSP GSSPSGRSVK
110 120 130 140 150
PESPGVRRKR VSPVPFQSGR ITPPRRAPSP DGFSPYSPEE TSRRVNKVMR
160 170 180 190 200
ARLYLLQQIG PNSFLIGGDS PDNKYRVFIG PQNCSCGRGA FCIHLLFVML
210 220 230 240 250
RVFQLEPSDP MLWRKTLKNF EVESLFQKYH SRRSSRIKAP SRNTIQKFVS
260
RMSNCHTLSS SSTS
Length:264
Mass (Da):29,724
Last modified:May 27, 2015 - v5
Checksum:i9E9B698A02CEB177
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei264 – 2641Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118704 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000145055; ENSMUSP00000117863; ENSMUSG00000021754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118704 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104890.

Proteomic databases

PRIDEiD3YVX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000145055; ENSMUSP00000117863; ENSMUSG00000021754.

Organism-specific databases

MGIiMGI:1346872. Map3k1.

Phylogenomic databases

GeneTreeiENSGT00790000122958.

Enzyme and pathway databases

ReactomeiREACT_271614. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_273973. MyD88 cascade initiated on plasma membrane.
REACT_275137. TRAF6 mediated NF-kB activation.
REACT_309099. MyD88:Mal cascade initiated on plasma membrane.
REACT_314186. FCERI mediated MAPK activation.

Miscellaneous databases

ChiTaRSiMap3k1. mouse.
NextBioi35548973.
SOURCEiSearch...

Gene expression databases

BgeeiD3YVX9.
ExpressionAtlasiD3YVX9. baseline and differential.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YVX9_MOUSE
AccessioniPrimary (citable) accession number: D3YVX9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: May 27, 2015
Last modified: June 24, 2015
This is version 41 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.