ID   D3YVS6_MOUSE            Unreviewed;       197 AA.
AC   D3YVS6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=Megakaryocyte and platelet inhibitory receptor G6b {ECO:0000313|Ensembl:ENSMUSP00000094950.2};
GN   Name=Mpig6b {ECO:0000313|Ensembl:ENSMUSP00000094950.2,
GN   ECO:0000313|MGI:MGI:2146995};
GN   Synonyms=G6b {ECO:0000313|MGI:MGI:2146995};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000094950.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000094950.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000094950.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000094950.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000094950.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001028393.1; NM_001033221.3.
DR   AlphaFoldDB; D3YVS6; -.
DR   SMR; D3YVS6; -.
DR   MaxQB; D3YVS6; -.
DR   ProteomicsDB; 348903; -.
DR   Antibodypedia; 27557; 113 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000097337.8; ENSMUSP00000094950.2; ENSMUSG00000073414.9.
DR   GeneID; 106722; -.
DR   UCSC; uc008cfj.1; mouse.
DR   AGR; MGI:2146995; -.
DR   CTD; 80739; -.
DR   MGI; MGI:2146995; Mpig6b.
DR   VEuPathDB; HostDB:ENSMUSG00000073414; -.
DR   GeneTree; ENSGT00390000017793; -.
DR   OrthoDB; 4640612at2759; -.
DR   PhylomeDB; D3YVS6; -.
DR   TreeFam; TF337394; -.
DR   BioGRID-ORCS; 106722; 2 hits in 77 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 17.
DR   Bgee; ENSMUSG00000073414; Expressed in bone marrow and 39 other cell types or tissues.
DR   ExpressionAtlas; D3YVS6; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028070; G6B.
DR   InterPro; IPR048308; G6B_V-set.
DR   PANTHER; PTHR37347; MEGAKARYOCYTE AND PLATELET INHIBITORY RECEPTOR G6B; 1.
DR   PANTHER; PTHR37347:SF1; MEGAKARYOCYTE AND PLATELET INHIBITORY RECEPTOR G6B; 1.
DR   Pfam; PF15096; G6B; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:D3YVS6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..197
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003053081"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          18..129
FT                   /note="G6b-B extracellular V-set Ig-like"
FT                   /evidence="ECO:0000259|Pfam:PF15096"
SQ   SEQUENCE   197 AA;  21199 MW;  44C41105BB238D2B CRC64;
     MALVLPLLPL LLSKVQGNPE VSLEGSPGDR VNLSCIGVSD PTRWAWAPSF PACKGLSKGR
     RPILWASTRG TPTVLQHFSG RLRSLDNGIK RLELLLSAGD SGTFFCKGRH ENESRTVLQV
     LGDKAGCRPA GSTHGYEYPK VLIPLLGVGL VLGLGVAGVV WRRRRACTTL IWTTLSSGGT
     AGCPQWFLVM PPLSMRL
//