ID   D3YVG0_MOUSE            Unreviewed;      1001 AA.
AC   D3YVG0;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 2.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN   Name=Slc4a5 {ECO:0000313|Ensembl:ENSMUSP00000041007.8,
GN   ECO:0000313|MGI:MGI:2443220};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000041007.8, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000041007.8, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000041007.8,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000041007.8}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000041007.8};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362035}.
CC   -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC       {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR   RefSeq; NP_001159539.1; NM_001166067.1.
DR   AlphaFoldDB; D3YVG0; -.
DR   SMR; D3YVG0; -.
DR   MaxQB; D3YVG0; -.
DR   PeptideAtlas; D3YVG0; -.
DR   ProteomicsDB; 322760; -.
DR   Antibodypedia; 47475; 92 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000039212.8; ENSMUSP00000041007.8; ENSMUSG00000068323.13.
DR   GeneID; 232156; -.
DR   KEGG; mmu:232156; -.
DR   UCSC; uc012enx.1; mouse.
DR   AGR; MGI:2443220; -.
DR   CTD; 57835; -.
DR   MGI; MGI:2443220; Slc4a5.
DR   VEuPathDB; HostDB:ENSMUSG00000068323; -.
DR   GeneTree; ENSGT00940000157488; -.
DR   HOGENOM; CLU_002289_5_0_1; -.
DR   OMA; RETEGNC; -.
DR   OrthoDB; 1013180at2759; -.
DR   BioGRID-ORCS; 232156; 2 hits in 80 CRISPR screens.
DR   ChiTaRS; Slc4a5; mouse.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000068323; Expressed in choroid plexus of fourth ventricle and 67 other cell types or tissues.
DR   ExpressionAtlas; D3YVG0; baseline and differential.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR   GO; GO:0098660; P:inorganic ion transmembrane transport; IEA:UniProt.
DR   GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR   Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR   InterPro; IPR013769; Band3_cytoplasmic_dom.
DR   InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR   InterPro; IPR003020; HCO3_transpt_euk.
DR   InterPro; IPR003024; Na/HCO3_transpt.
DR   InterPro; IPR016152; PTrfase/Anion_transptr.
DR   NCBIfam; TIGR00834; ae; 1.
DR   PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR   PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR   Pfam; PF07565; Band_3_cyto; 1.
DR   Pfam; PF00955; HCO3_cotransp; 1.
DR   PRINTS; PR01231; HCO3TRNSPORT.
DR   PRINTS; PR01232; NAHCO3TRSPRT.
DR   SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR   Genevisible; D3YVG0; MM.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU362035};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:D3YVG0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362035};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362035};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT   TRANSMEM        399..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        433..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        484..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        517..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        620..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        658..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        706..724
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        744..760
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        806..825
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        831..851
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        901..918
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   DOMAIN          26..292
FT                   /note="Band 3 cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF07565"
FT   DOMAIN          370..884
FT                   /note="Bicarbonate transporter-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF00955"
FT   REGION          107..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1001 AA;  111516 MW;  3C75F2BD60AA80DF CRC64;
     MDTLQHDGDQ MEWKESARWI KFEEKVEEGG ERWSKPHVST LSLHSLFELR TCLQTGTVLL
     DLDSCSLPQI IDDVIEKQIE DGLLRPELRE RVSYVLLRKH RHQTKKPIHR SLADIGKSVS
     TTNRSSARSS SAGPTLHRST EDLRIRQSTS YGHLCHAQSR SMNDISHTPN TDQRKNKFMK
     KIPKDSEASN VLVGEVDFLD QPFIAFVRLV QSAMLGGVTE VPVPTRFLFI LLGPSGRAKS
     YNEIGRAIAT LMVDDLFSDV AYKARNREDL IAGIDEFLDE VIVLPPGEWD PNIRIEPPKK
     VPSADKRKSV FSLAEPGQMN GSVGGGGASA GGGGSGGGAG GSGAGGVGSG DEAEMPAMHE
     IGEELIWTGR FFGGLCLDVK RKLPWFPSDF YDGFHLQSIS AVLFIYLGCI TNAITFGGLL
     GDATDNYQGV MESFLGTAMA GSLFCLFSGQ PLIILSSTGP ILIFEKLLFD FSKANGLDYM
     EFRLWIGLHS AIQCLILVAT DASFIIKYIT RFTEEGFSTL ISFIFIYDAI KKMIGAFKYY
     PINTDFKPDF ITTYKCECVA PDTVNTTTVN ASAPLAPNTN TSLYTPLNLT ALDWSLLSKK
     ECLSYGGRLL GSSCQFVPDL ALMSFILFFG TYSMTLTLKK FKFSRYFPTK VRTLVADFSI
     VFSILLFCGI DACFGLQTPK LHVPSVIKPT RPDRGWFVAP FGKNPWWVYP ASILPALLVT
     ILIFMDQQIT AVIVNRKENK LRKAAGYHLD LFWVGILMAL CSFTGLPWYV AATVISIAHI
     DSLKMETETS APGEQPQFLG VREQRVTGVM VFILTGISVF LAPILKYIPM PVLYGVFLYM
     GVASLNGIQF WERCKLFLMP AKHQPDHAFL RHVPLRRIHL FTLVQILCLA LLWILKSTMA
     AIIFPVMILG LIIVRRLLDL IFSQHDLAWI DNILPEKDKK ETDKKKKRRK EVHETAEKEV
     AMPQFLPPSV VKIPMEGIPS DPQNGIHCVA RKRSSSWSYS L
//