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Protein

Matrix metalloproteinase

Gene

Mmp27

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiM10.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:Mmp27Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3039232. Mmp27.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, ZymogenUniRule annotation

PTM databases

iPTMnetiD3YV89.
PhosphoSitePlusiD3YV89.

Expressioni

Gene expression databases

BgeeiENSMUSG00000070323.
ExpressionAtlasiD3YV89. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091423.

Structurei

3D structure databases

ProteinModelPortaliD3YV89.
SMRiD3YV89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati317 – 366HemopexinPROSITE-ProRule annotationAdd BLAST50
Repeati367 – 412HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati414 – 462HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati463 – 506HemopexinPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.
HOGENOMiHOG000217927.
OMAiPHACDPD.
OrthoDBiEOG091G03DP.
PhylomeDBiD3YV89.
TreeFamiTF315428.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 2 hits.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR028732. MMP27.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF171. PTHR10201:SF171. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 2 hits.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.

Sequencei

Sequence statusi: Complete.

D3YV89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYKQKQALT EETGMKCLLS LMVNFITLSA AFPPDRKDKN EENNQLAQAY
60 70 80 90 100
LNQFYSLEIE GSHFVQSKNR SLFDGKLREM QAFFGLTVTG KLDSDTLAIM
110 120 130 140 150
KVPRCGVPDV GQYGYTLPGW RKYSLTYRIM NYTPDMTPAD VDEAIQKALQ
160 170 180 190 200
VWSKVTPLTF TRISKGVADI MIAFRTGGKA CSEGSDFFED HRELTYLPIN
210 220 230 240 250
CLSVHGWCPR HFDGPLGVLG HAFPPGLGLG GDTHFDEDET WIAKDGEGFN
260 270 280 290 300
LFLVAAHEFG HSLGLSHSND QTALMFPNYI SLDPSKYPLS QDDIDGIQSI
310 320 330 340 350
YGSPPKVTTK PSGNSEPHAC DPTLTFDAIT TFRREVMFFK GRHLWRVYSD
360 370 380 390 400
IAGAEFEFID SFWPSLPADL QAAYESPRDE LLVFKDENFW VIRGYSVLPG
410 420 430 440 450
YPKSIHTLGF PRRVKKIDAA VCDHDTRKTF FFVGIWCWRY DEMAQAMDRG
460 470 480 490 500
FPQRIIKCFP GIRLRVDAVF QHNGFLYFFH GSRQFEYDMK AKNITQVIKT
510 520 530 540 550
NSWFLCNEPL NASFNVSVKG KANSIGTVIL HHKRLSLLTF SIVHVLTKTY

N
Length:551
Mass (Da):62,544
Last modified:April 20, 2010 - v1
Checksum:iDCB1EB235899FD0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115689 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000151853; ENSMUSP00000117469; ENSMUSG00000070323.
UCSCiuc009ocs.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiD3YV89_MOUSE
AccessioniPrimary (citable) accession number: D3YV89
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 27, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported