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Protein
Submitted name:

Serine/threonine-protein kinase receptor R3

Gene

Acvrl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. activin binding Source: MGI
  2. activin receptor activity, type I Source: MGI
  3. ATP binding Source: MGI
  4. protein kinase binding Source: MGI
  5. protein serine/threonine kinase activity Source: MGI
  6. receptor signaling protein serine/threonine kinase activity Source: Ensembl
  7. SMAD binding Source: MGI
  8. transforming growth factor beta-activated receptor activity Source: MGI
  9. transforming growth factor beta binding Source: MGI
  10. transforming growth factor beta receptor activity, type I Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: MGI
  2. blood circulation Source: MGI
  3. blood vessel morphogenesis Source: MGI
  4. BMP signaling pathway Source: MGI
  5. cellular response to BMP stimulus Source: MGI
  6. cellular response to transforming growth factor beta stimulus Source: MGI
  7. endothelial tube morphogenesis Source: MGI
  8. in utero embryonic development Source: MGI
  9. lymphatic endothelial cell differentiation Source: MGI
  10. negative regulation of blood vessel endothelial cell migration Source: MGI
  11. negative regulation of cell adhesion Source: MGI
  12. negative regulation of cell growth Source: MGI
  13. negative regulation of cell migration Source: MGI
  14. negative regulation of cell proliferation Source: MGI
  15. negative regulation of DNA biosynthetic process Source: MGI
  16. negative regulation of endothelial cell migration Source: MGI
  17. negative regulation of focal adhesion assembly Source: MGI
  18. positive regulation of angiogenesis Source: MGI
  19. positive regulation of BMP signaling pathway Source: MGI
  20. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  21. positive regulation of transcription, DNA-templated Source: MGI
  22. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  23. protein heterooligomerization Source: Ensembl
  24. protein phosphorylation Source: MGI
  25. regulation of blood pressure Source: MGI
  26. regulation of transcription, DNA-templated Source: MGI
  27. signal transduction Source: MGI
  28. transforming growth factor beta receptor signaling pathway Source: MGI
  29. wound healing, spreading of epidermal cells Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase receptor R3Imported
Gene namesi
Name:Acvrl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1338946. Acvrl1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. dendrite Source: Ensembl
  3. integral component of plasma membrane Source: MGI
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3YUY5.
ExpressionAtlasiD3YUY5. baseline and differential.

Interactioni

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118876.

Family and domain databases

InterProiIPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.

Sequencei

Sequence statusi: Fragment.

D3YUY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLGSFRRGL LMLSVAFGLT RGDLAKPSKL VNCTCESPHC KRPFCQGSWC
60 70
TVVLVREQGR HPQVYRGCGS LNQELC
Length:76
Mass (Da):8,429
Last modified:April 20, 2010 - v1
Checksum:iCA4A2348973AA4AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei76 – 761Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104834 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000124151; ENSMUSP00000114829; ENSMUSG00000000530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104834 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiD3YUY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124151; ENSMUSP00000114829; ENSMUSG00000000530.

Organism-specific databases

MGIiMGI:1338946. Acvrl1.

Phylogenomic databases

GeneTreeiENSGT00760000118876.

Miscellaneous databases

NextBioi35548736.
SOURCEiSearch...

Gene expression databases

BgeeiD3YUY5.
ExpressionAtlasiD3YUY5. baseline and differential.

Family and domain databases

InterProiIPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YUY5_MOUSE
AccessioniPrimary (citable) accession number: D3YUY5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.