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Protein
Submitted name:

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Gene

Pip5k1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: MGI
  2. kinase binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton reorganization Source: MGI
  2. activation of Rac GTPase activity Source: MGI
  3. cell chemotaxis Source: MGI
  4. fibroblast migration Source: MGI
  5. focal adhesion assembly Source: MGI
  6. phosphatidylinositol metabolic process Source: MGI
  7. phosphatidylinositol phosphorylation Source: MGI
  8. phospholipid biosynthetic process Source: MGI
  9. protein targeting to plasma membrane Source: MGI
  10. ruffle assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaImported
Gene namesi
Name:Pip5k1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:107929. Pip5k1a.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. focal adhesion Source: MGI
  3. lamellipodium Source: MGI
  4. nuclear speck Source: MGI
  5. nucleoplasm Source: MGI
  6. nucleus Source: MGI
  7. plasma membrane Source: MGI
  8. ruffle membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3YUY3.
ExpressionAtlasiD3YUY3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3YUY3.
SMRiD3YUY3. Positions 66-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains PIPK domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119184.
HOGENOMiHOG000193876.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YUY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASASSGPAA AGFSSLDAGA PAGTAASGIK RATVSEGPSA SVMPVKKIGH
60 70 80 90 100
RSVDSSGETT YKKTTSSALK GAIQLGITHT VGSLSTKPER DVLMQDFYVV
110 120 130 140 150
ESIFFPSEGS NLTPAHHYND FRFKTYAPVA FRYFRELFGI RPDDYLYSLC
160 170 180 190 200
SEPLIELSNS GASGSLFYVS SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN
210 220 230 240 250
QNPRTLLPKF YGLYCVQAGG KNIRIVVMNN LLPRSVKMHM KYDLKGSTYK
260 270 280 290 300
RRASQKEREK TLPTFKDLDF LQDIPDGLFL DADMYSALCK TLQRDCLVLQ
310 320 330 340 350
SFKIMDYSLL MSIHNMDHAQ REPTSNDTQY SADTRRPAPQ KALYSTAMES
360 370 380 390 400
IQGEARRGGT VETEDHMGGI PARNNKGERL LLYIGIIDIL QSYRFVKKLE
410 420 430 440 450
HSWKALVHDG DTVSVHRPGF YAERFQRFMC NTVFKKIPYV HLGRPDVLPQ
460 470 480 490
TPPLEEISEG SPVPGPSFSP VVGQPLQILN LSSTLEKLDV AESEFTH
Length:497
Mass (Da):55,361
Last modified:April 20, 2010 - v1
Checksum:iCD14065CB3B087F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087062 Genomic DNA. No translation available.
AC131769 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000107232; ENSMUSP00000102851; ENSMUSG00000028126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087062 Genomic DNA. No translation available.
AC131769 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD3YUY3.
SMRiD3YUY3. Positions 66-351.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107232; ENSMUSP00000102851; ENSMUSG00000028126.

Organism-specific databases

MGIiMGI:107929. Pip5k1a.

Phylogenomic databases

GeneTreeiENSGT00760000119184.
HOGENOMiHOG000193876.

Miscellaneous databases

ChiTaRSiPip5k1a. mouse.
NextBioi35548735.
SOURCEiSearch...

Gene expression databases

BgeeiD3YUY3.
ExpressionAtlasiD3YUY3. baseline and differential.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YUY3_MOUSE
AccessioniPrimary (citable) accession number: D3YUY3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.