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Protein
Submitted name:

F-box/WD repeat-containing protein 7

Gene

Fbxw7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
F-box/WD repeat-containing protein 7Imported
Gene namesi
Name:Fbxw7Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1354695. Fbxw7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103305.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini281 – 32747F-boxInterPro annotationAdd
BLAST
Domaini379 – 662284WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili94 – 12734Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
ENOG410XRWX. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000236264.
TreeFamiTF101074.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YUA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQELLSVGS KRRRTGGSLR GNASSSQVDE GQMNRVVEED PQQQARHQEE
60 70 80 90 100
EHTARNGELV GANPRPGDQN DTQQGQVEEN NNRFISVDED SSGNQEEQEE
110 120 130 140 150
DEEHAGEQEE EEEEEEEEEE MDQESDDFDP SDDSSREDEH THNSNVTNCS
160 170 180 190 200
SVSDLPAHQL SSPFYTKTTK MKRKLDHGSE VRSFSLGKKP CKVSDYTSTT
210 220 230 240 250
GLVPCSATPT TFGDLRAANG QGQQRRRITS VQPPTGLQEW LKMFQSWSGP
260 270 280 290 300
EKLLALDELI DSCEPTQVKH MMQVIEPQFQ RDFISLLPKE LALYVLSFLE
310 320 330 340 350
PKDLLQAAQT CRYWRILAED NLLWREKCKE EGIDEPLHIK RRKIIKPGFI
360 370 380 390 400
HSPWKSAYIR QHRIDTNWRR GELKSPKVLK GHDDHVITCL QFCGNRIVSG
410 420 430 440 450
SDDNTLKVWS AVTGKCLRTL VGHTGGVWSS QMRDNIIISG STDRTLKVWN
460 470 480 490 500
AETGECIHTL YGHTSTVRCM HLHEKRVVSG SRDATLRVWD IETGQCLHVL
510 520 530 540 550
MGHVAAVRCV QYDGRRVVSG AYDFMVKVWD PETETCLHTL QGHTNRVYSL
560 570 580 590 600
QFDGIHVVSG SLDTSIRVWD VETGNCIHTL TGHQSLTSGM ELKDNILVSG
610 620 630 640 650
NADSTVKIWD IKTGQCLQTL QGPSKHQSAV TCLQFNKNFV ITSSDDGTVK
660 670 680 690 700
LWDLKTGEFI RNLVTLESGG SGGVVWRIRA SNTKLVCAVG SRNGTEETKL
710
LVLDFDVDMK
Length:710
Mass (Da):79,848
Last modified:April 20, 2010 - v1
Checksum:i9D56F7E81E6E390B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124496 Genomic DNA. No translation available.
AC158583 Genomic DNA. No translation available.
RefSeqiNP_001171244.1. NM_001177773.1.
NP_001171245.1. NM_001177774.1.
XP_006501719.1. XM_006501656.2.
XP_006501720.1. XM_006501657.2.
UniGeneiMm.196475.

Genome annotation databases

EnsembliENSMUST00000107678; ENSMUSP00000103305; ENSMUSG00000028086.
ENSMUST00000107679; ENSMUSP00000103306; ENSMUSG00000028086.
GeneIDi50754.
UCSCiuc008pqk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124496 Genomic DNA. No translation available.
AC158583 Genomic DNA. No translation available.
RefSeqiNP_001171244.1. NM_001177773.1.
NP_001171245.1. NM_001177774.1.
XP_006501719.1. XM_006501656.2.
XP_006501720.1. XM_006501657.2.
UniGeneiMm.196475.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107678; ENSMUSP00000103305; ENSMUSG00000028086.
ENSMUST00000107679; ENSMUSP00000103306; ENSMUSG00000028086.
GeneIDi50754.
UCSCiuc008pqk.2. mouse.

Organism-specific databases

CTDi55294.
MGIiMGI:1354695. Fbxw7.

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
ENOG410XRWX. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000236264.
TreeFamiTF101074.

Miscellaneous databases

NextBioi307631.
SOURCEiSearch...

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YUA5_MOUSE
AccessioniPrimary (citable) accession number: D3YUA5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 11, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.