D3YU89 (D3YU89_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Citron Rho-interacting kinase Ensembl ENSMUSP00000099620

Gene names

Name:

Cit Ensembl ENSMUSP00000099620 MGI 105313

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000099620

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2070 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS017892
Sequence similarities	Contains 1 AGC-kinase C-terminal domain. Contains 1 PH domain. SAAS SAAS002219 Contains 1 protein kinase domain. SAAS SAAS017892
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000099620

Ontologies

Keywords
Domain	Zinc-finger SAAS SAAS017892
Ligand	ATP-binding SAAS SAAS017892 RuleBase RU000304 Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS017892 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokinesis Inferred from mutant phenotype PubMed 11086988PubMed 12432070. Source: MGI dendrite development Inferred from mutant phenotype PubMed 12781320. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: InterPro mitotic metaphase/anaphase transition Inferred from mutant phenotype PubMed 12764032. Source: MGI mitotic sister chromatid segregation Inferred from mutant phenotype PubMed 12764032. Source: MGI negative regulation of dendrite morphogenesis Inferred from direct assay PubMed 12781320. Source: MGI negative regulation of neuron differentiation Inferred from sequence orthology PubMed 17488780. Source: MGI spermatogenesis Inferred from mutant phenotype PubMed 12432070. Source: MGI
Cellular_component	actin cytoskeleton Inferred from direct assay PubMed 9792683. Source: MGI ruffle Inferred from direct assay PubMed 12781320. Source: MGI vacuole Inferred from direct assay PubMed 17488780. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from direct assay PubMed 9792683. Source: MGI small GTPase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3YU89 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: 79701BCB76A3308A	FASTA	2,070	237,060
	10 20 30 40 50 60 MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG MLDALFALFE 70 80 90 100 110 120 ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR SLVGCGHFAE VQVVREKATG 130 140 150 160 170 180 DVYAMKIMKK KALLAQEQVS FFEEERNILS RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG 190 200 210 220 230 240 DLLSLLNRYE DQLDESMIQF YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF 250 260 270 280 290 300 GSAAKMNSNK VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT 310 320 330 340 350 360 PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF EGLCCHPFFA 370 380 390 400 410 420 RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV CQLSPSGFSG EELPFVGFSY 430 440 450 460 470 480 SKALGYLGRS ESVVSSLDSP AKVSSMEKKL LIKSKELQDS QDKCHKMEQE MTRLHRRVSE 490 500 510 520 530 540 VEAVLSQKEV ELKASETQRS LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD 550 560 570 580 590 600 IREQSRKLQE IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR 610 620 630 640 650 660 KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA STEATELLQN 670 680 690 700 710 720 IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE NKVKRLETME RRENRLKDDI 730 740 750 760 770 780 QTKSEQIQQM ADKILELEEK HREAQVSAQH LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK 790 800 810 820 830 840 ESLENMMQRH EEEAHEKGKI LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ 850 860 870 880 890 900 RNMKAQEEMI SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKS RLLELETRLR 910 920 930 940 950 960 EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT ELEETTAEAE 970 980 990 1000 1010 1020 EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED NAELNNQNFY LSKQLDEASG 1030 1040 1050 1060 1070 1080 ANDEIVQLRS EVDHLRREIT EREMQLTSQK QTMEALKTTC TMLEEQVLDL EALNDELLEK 1090 1100 1110 1120 1130 1140 ERQWEAWRSV LGDEKSQFEC RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE 1150 1160 1170 1180 1190 1200 ILALQQALKE QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL 1210 1220 1230 1240 1250 1260 QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK VKMEGTISQQ 1270 1280 1290 1300 1310 1320 TKLIDFLQAK MDQPAKKKKG LFSRRKEDPA LPTQVPLQYN ELKLALEKEK ARCAELEEAL 1330 1340 1350 1360 1370 1380 QKTRIELRSA REEAAHRKAT DHPHPSTPAT ARQQIAMSAI VRSPEHQPSA MSLLAPPSSR 1390 1400 1410 1420 1430 1440 RKESSTPEEF SRRLKERMHH NIPHRFNVGL NMRATKCAVC LDTVHFGRQA SKCLECQVMC 1450 1460 1470 1480 1490 1500 HPKCSTCLPA TCGLPAEYAT HFTEAFCRDK MNSPGLQSKE PGSSLHLEGW MKVPRNNKRG 1510 1520 1530 1540 1550 1560 QQGWDRKYIV LEGSKVLIYD NEAREAGQRP VEEFELCLPD GDVSIHGAVG ASELANTAKA 1570 1580 1590 1600 1610 1620 DVPYILKMES HPHTTCWPGR TLYLLAPSFP DKQRWVTALE SVVAGGRVSR EKAEADAKLL 1630 1640 1650 1660 1670 1680 GNSLLKLEGD DRLDMNCTLP FSDQVVLVGT EEGLYALNVL KNSLTHIPGI GAVFQIYIIK 1690 1700 1710 1720 1730 1740 DLEKLLMIAG EERALCLVDV KKVKQSLAQS HLPAQPDVSP NIFEAVKGCH LFAAGKIENS 1750 1760 1770 1780 1790 1800 LCICAAMPSK VVILRYNDNL SKYCIRKEIE TSEPCSCIHF TNYSILIGTN KFYEIDMKQY 1810 1820 1830 1840 1850 1860 TLDEFLDKND HSLAPAVFAS SSNSFPVSIV QANSAGQREE YLLCFHEFGV FVDSYGRRSR 1870 1880 1890 1900 1910 1920 TDDLKWSRLP LAFAYREPYL FVTHFNSLEV IEIQARSSLG SPARAYLEIP NPRYLGPAIS 1930 1940 1950 1960 1970 1980 SGAIYLASSY QDKLRVICCK GNLVKESGTE QHRVPSTSRS SPNKRGPPTY NEHITKRVAS 1990 2000 2010 2020 2030 2040 SPAPPEGPSH PREPSTPHRY RDREGRTELR RDKSPGRPLE REKSPGRMLS TRRERSPGRL 2050 2060 2070 FEDSSRGRLP AGAVRTPLSQ VNKVWDQSSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000099620.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000099620.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC115795 Genomic DNA. No translation available. AC162461 Genomic DNA. No translation available.
IPI	IPI00406762.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000102560; ENSMUSP00000099620; ENSMUSG00000029516.
UCSC	uc008zer.1. mouse.
Organism-specific databases
MGI	MGI:105313. Cit.
Phylogenomic databases
GeneTree	ENSGT00690000101983.
HOGENOM	HOG000015347.
OMA	MKAKDQG.
Gene expression databases
ArrayExpress	D3YU89.
Bgee	D3YU89.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000961. AGC-kinase_C. IPR001180. Citron. IPR017405. Citron_Rho-interacting_kinase. IPR011009. Kinase-like_dom. IPR011993. PH_like_dom. IPR017892. Pkinase_C. IPR001849. Pleckstrin_homology. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
PANTHER	PTHR22988:SF1. PTHR22988:SF1. 1 hit.
Pfam	PF00780. CNH. 1 hit. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
PIRSF	PIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMART	SM00109. C1. 1 hit. SM00036. CNH. 1 hit. SM00233. PH. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS50219. CNH. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35548555.
SOURCE	Search...

Entry information

Entry name

D3YU89_MOUSE

Accession

Primary (citable) accession number: D3YU89

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)