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D3YU89 (D3YU89_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length2070 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. SAAS SAAS017892

Sequence similarities

Contains AGC-kinase C-terminal domain. SAAS SAAS017892

Contains PH domain. SAAS SAAS002219

Contains protein kinase domain. SAAS SAAS017892

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000099620

Ontologies

Keywords
   DomainZinc-finger SAAS SAAS017892
   LigandATP-binding SAAS SAAS017892 RuleBase RU000304
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Serine/threonine-protein kinase SAAS SAAS017892
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdendrite development

Inferred from mutant phenotype PubMed 12781320. Source: MGI

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

metaphase/anaphase transition of mitotic cell cycle

Inferred from mutant phenotype PubMed 12764032. Source: MGI

mitotic sister chromatid segregation

Inferred from mutant phenotype PubMed 12764032. Source: MGI

negative regulation of dendrite morphogenesis

Inferred from direct assay PubMed 12781320. Source: MGI

negative regulation of neuron differentiation

Inferred from sequence orthology PubMed 17488780. Source: MGI

spermatogenesis

Inferred from mutant phenotype PubMed 12432070. Source: MGI

   Cellular_componentactin cytoskeleton

Inferred from direct assay PubMed 9792683. Source: MGI

cytoplasm

Inferred from direct assay PubMed 12781320. Source: MGI

ruffle

Inferred from direct assay PubMed 12781320. Source: MGI

vacuole

Inferred from direct assay PubMed 17488780. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from direct assay PubMed 9792683. Source: MGI

small GTPase regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
D3YU89 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 79701BCB76A3308A

FASTA2,070237,060
        10         20         30         40         50         60 
MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG MLDALFALFE 

        70         80         90        100        110        120 
ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR SLVGCGHFAE VQVVREKATG 

       130        140        150        160        170        180 
DVYAMKIMKK KALLAQEQVS FFEEERNILS RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG 

       190        200        210        220        230        240 
DLLSLLNRYE DQLDESMIQF YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF 

       250        260        270        280        290        300 
GSAAKMNSNK VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT 

       310        320        330        340        350        360 
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF EGLCCHPFFA 

       370        380        390        400        410        420 
RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV CQLSPSGFSG EELPFVGFSY 

       430        440        450        460        470        480 
SKALGYLGRS ESVVSSLDSP AKVSSMEKKL LIKSKELQDS QDKCHKMEQE MTRLHRRVSE 

       490        500        510        520        530        540 
VEAVLSQKEV ELKASETQRS LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD 

       550        560        570        580        590        600 
IREQSRKLQE IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR 

       610        620        630        640        650        660 
KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA STEATELLQN 

       670        680        690        700        710        720 
IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE NKVKRLETME RRENRLKDDI 

       730        740        750        760        770        780 
QTKSEQIQQM ADKILELEEK HREAQVSAQH LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK 

       790        800        810        820        830        840 
ESLENMMQRH EEEAHEKGKI LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ 

       850        860        870        880        890        900 
RNMKAQEEMI SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKS RLLELETRLR 

       910        920        930        940        950        960 
EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT ELEETTAEAE 

       970        980        990       1000       1010       1020 
EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED NAELNNQNFY LSKQLDEASG 

      1030       1040       1050       1060       1070       1080 
ANDEIVQLRS EVDHLRREIT EREMQLTSQK QTMEALKTTC TMLEEQVLDL EALNDELLEK 

      1090       1100       1110       1120       1130       1140 
ERQWEAWRSV LGDEKSQFEC RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE 

      1150       1160       1170       1180       1190       1200 
ILALQQALKE QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL 

      1210       1220       1230       1240       1250       1260 
QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK VKMEGTISQQ 

      1270       1280       1290       1300       1310       1320 
TKLIDFLQAK MDQPAKKKKG LFSRRKEDPA LPTQVPLQYN ELKLALEKEK ARCAELEEAL 

      1330       1340       1350       1360       1370       1380 
QKTRIELRSA REEAAHRKAT DHPHPSTPAT ARQQIAMSAI VRSPEHQPSA MSLLAPPSSR 

      1390       1400       1410       1420       1430       1440 
RKESSTPEEF SRRLKERMHH NIPHRFNVGL NMRATKCAVC LDTVHFGRQA SKCLECQVMC 

      1450       1460       1470       1480       1490       1500 
HPKCSTCLPA TCGLPAEYAT HFTEAFCRDK MNSPGLQSKE PGSSLHLEGW MKVPRNNKRG 

      1510       1520       1530       1540       1550       1560 
QQGWDRKYIV LEGSKVLIYD NEAREAGQRP VEEFELCLPD GDVSIHGAVG ASELANTAKA 

      1570       1580       1590       1600       1610       1620 
DVPYILKMES HPHTTCWPGR TLYLLAPSFP DKQRWVTALE SVVAGGRVSR EKAEADAKLL 

      1630       1640       1650       1660       1670       1680 
GNSLLKLEGD DRLDMNCTLP FSDQVVLVGT EEGLYALNVL KNSLTHIPGI GAVFQIYIIK 

      1690       1700       1710       1720       1730       1740 
DLEKLLMIAG EERALCLVDV KKVKQSLAQS HLPAQPDVSP NIFEAVKGCH LFAAGKIENS 

      1750       1760       1770       1780       1790       1800 
LCICAAMPSK VVILRYNDNL SKYCIRKEIE TSEPCSCIHF TNYSILIGTN KFYEIDMKQY 

      1810       1820       1830       1840       1850       1860 
TLDEFLDKND HSLAPAVFAS SSNSFPVSIV QANSAGQREE YLLCFHEFGV FVDSYGRRSR 

      1870       1880       1890       1900       1910       1920 
TDDLKWSRLP LAFAYREPYL FVTHFNSLEV IEIQARSSLG SPARAYLEIP NPRYLGPAIS 

      1930       1940       1950       1960       1970       1980 
SGAIYLASSY QDKLRVICCK GNLVKESGTE QHRVPSTSRS SPNKRGPPTY NEHITKRVAS 

      1990       2000       2010       2020       2030       2040 
SPAPPEGPSH PREPSTPHRY RDREGRTELR RDKSPGRPLE REKSPGRMLS TRRERSPGRL 

      2050       2060       2070 
FEDSSRGRLP AGAVRTPLSQ VNKVWDQSSV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC115795 Genomic DNA. No translation available.
AC162461 Genomic DNA. No translation available.
RefSeqXP_006530203.1. XM_006530140.1.
UniGeneMm.426282.
Mm.8321.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102560; ENSMUSP00000099620; ENSMUSG00000029516.
GeneID12704.

Organism-specific databases

MGIMGI:105313. Cit.

Phylogenomic databases

GeneTreeENSGT00750000117422.
HOGENOMHOG000015347.
OMAMKAKDQG.

Gene expression databases

ArrayExpressD3YU89.
BgeeD3YU89.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR000961. AGC-kinase_C.
IPR001180. Citron.
IPR017405. Citron_Rho-interacting_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR001849. Pleckstrin_homology.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020684. Rho-assoc_coiled-coil_kin.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR22988:SF3. PTHR22988:SF3. 1 hit.
PfamPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFPIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMARTSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35548555.
SOURCESearch...

Entry information

Entry nameD3YU89_MOUSE
AccessionPrimary (citable) accession number: D3YU89
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)