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D3YU89

- D3YU89_MOUSE

UniProt

D3YU89 - D3YU89_MOUSE

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Protein
Submitted name:

Citron Rho-interacting kinase

Gene
Cit
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: MGI
  4. protein serine/threonine kinase activity Source: MGI
  5. small GTPase regulator activity Source: InterPro

GO - Biological processi

  1. dendrite development Source: MGI
  2. intracellular signal transduction Source: InterPro
  3. metaphase/anaphase transition of mitotic cell cycle Source: MGI
  4. mitotic sister chromatid segregation Source: MGI
  5. negative regulation of dendrite morphogenesis Source: MGI
  6. negative regulation of neuron differentiation Source: MGI
  7. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Citron Rho-interacting kinaseImported
Gene namesi
Name:CitImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:105313. Cit.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: MGI
  2. cytoplasm Source: MGI
  3. ruffle Source: MGI
  4. vacuole Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiD3YU89.
BgeeiD3YU89.

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotations
Contains PH domain.SAAS annotations
Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117422.
HOGENOMiHOG000015347.
KOiK16308.
OMAiMKAKDQG.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR001180. Citron.
IPR017405. Citron_Rho-interacting_kinase.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YU89-1 [UniParc]FASTAAdd to Basket

« Hide

MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG     50
MLDALFALFE ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR 100
SLVGCGHFAE VQVVREKATG DVYAMKIMKK KALLAQEQVS FFEEERNILS 150
RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG DLLSLLNRYE DQLDESMIQF 200
YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF GSAAKMNSNK 250
VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT 300
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF 350
EGLCCHPFFA RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV 400
CQLSPSGFSG EELPFVGFSY SKALGYLGRS ESVVSSLDSP AKVSSMEKKL 450
LIKSKELQDS QDKCHKMEQE MTRLHRRVSE VEAVLSQKEV ELKASETQRS 500
LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD IREQSRKLQE 550
IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR 600
KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA 650
STEATELLQN IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE 700
NKVKRLETME RRENRLKDDI QTKSEQIQQM ADKILELEEK HREAQVSAQH 750
LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK ESLENMMQRH EEEAHEKGKI 800
LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ RNMKAQEEMI 850
SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKS RLLELETRLR 900
EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT 950
ELEETTAEAE EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED 1000
NAELNNQNFY LSKQLDEASG ANDEIVQLRS EVDHLRREIT EREMQLTSQK 1050
QTMEALKTTC TMLEEQVLDL EALNDELLEK ERQWEAWRSV LGDEKSQFEC 1100
RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE ILALQQALKE 1150
QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL 1200
QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK 1250
VKMEGTISQQ TKLIDFLQAK MDQPAKKKKG LFSRRKEDPA LPTQVPLQYN 1300
ELKLALEKEK ARCAELEEAL QKTRIELRSA REEAAHRKAT DHPHPSTPAT 1350
ARQQIAMSAI VRSPEHQPSA MSLLAPPSSR RKESSTPEEF SRRLKERMHH 1400
NIPHRFNVGL NMRATKCAVC LDTVHFGRQA SKCLECQVMC HPKCSTCLPA 1450
TCGLPAEYAT HFTEAFCRDK MNSPGLQSKE PGSSLHLEGW MKVPRNNKRG 1500
QQGWDRKYIV LEGSKVLIYD NEAREAGQRP VEEFELCLPD GDVSIHGAVG 1550
ASELANTAKA DVPYILKMES HPHTTCWPGR TLYLLAPSFP DKQRWVTALE 1600
SVVAGGRVSR EKAEADAKLL GNSLLKLEGD DRLDMNCTLP FSDQVVLVGT 1650
EEGLYALNVL KNSLTHIPGI GAVFQIYIIK DLEKLLMIAG EERALCLVDV 1700
KKVKQSLAQS HLPAQPDVSP NIFEAVKGCH LFAAGKIENS LCICAAMPSK 1750
VVILRYNDNL SKYCIRKEIE TSEPCSCIHF TNYSILIGTN KFYEIDMKQY 1800
TLDEFLDKND HSLAPAVFAS SSNSFPVSIV QANSAGQREE YLLCFHEFGV 1850
FVDSYGRRSR TDDLKWSRLP LAFAYREPYL FVTHFNSLEV IEIQARSSLG 1900
SPARAYLEIP NPRYLGPAIS SGAIYLASSY QDKLRVICCK GNLVKESGTE 1950
QHRVPSTSRS SPNKRGPPTY NEHITKRVAS SPAPPEGPSH PREPSTPHRY 2000
RDREGRTELR RDKSPGRPLE REKSPGRMLS TRRERSPGRL FEDSSRGRLP 2050
AGAVRTPLSQ VNKVWDQSSV 2070
Length:2,070
Mass (Da):237,060
Last modified:April 20, 2010 - v1
Checksum:i79701BCB76A3308A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115795 Genomic DNA. No translation available.
AC162461 Genomic DNA. No translation available.
RefSeqiXP_006530203.1. XM_006530140.1.
UniGeneiMm.426282.
Mm.8321.

Genome annotation databases

EnsembliENSMUST00000102560; ENSMUSP00000099620; ENSMUSG00000029516.
GeneIDi12704.
KEGGimmu:12704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115795 Genomic DNA. No translation available.
AC162461 Genomic DNA. No translation available.
RefSeqi XP_006530203.1. XM_006530140.1.
UniGenei Mm.426282.
Mm.8321.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102560 ; ENSMUSP00000099620 ; ENSMUSG00000029516 .
GeneIDi 12704.
KEGGi mmu:12704.

Organism-specific databases

CTDi 11113.
MGIi MGI:105313. Cit.

Phylogenomic databases

GeneTreei ENSGT00750000117422.
HOGENOMi HOG000015347.
KOi K16308.
OMAi MKAKDQG.

Miscellaneous databases

NextBioi 35548555.
SOURCEi Search...

Gene expression databases

ArrayExpressi D3YU89.
Bgeei D3YU89.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR001180. Citron.
IPR017405. Citron_Rho-interacting_kinase.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMARTi SM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YU89_MOUSE
AccessioniPrimary (citable) accession number: D3YU89
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi