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D3YU89

- D3YU89_MOUSE

UniProt

D3YU89 - D3YU89_MOUSE

Protein
Submitted name:

Citron Rho-interacting kinase

Gene

Cit

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: MGI
    4. protein serine/threonine kinase activity Source: MGI
    5. small GTPase regulator activity Source: InterPro

    GO - Biological processi

    1. dendrite development Source: MGI
    2. intracellular signal transduction Source: InterPro
    3. metaphase/anaphase transition of mitotic cell cycle Source: MGI
    4. mitotic sister chromatid segregation Source: MGI
    5. negative regulation of dendrite morphogenesis Source: MGI
    6. negative regulation of neuron differentiation Source: MGI
    7. spermatogenesis Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Citron Rho-interacting kinaseImported
    Gene namesi
    Name:CitImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:105313. Cit.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: MGI
    2. cytoplasm Source: MGI
    3. ruffle Source: MGI
    4. vacuole Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiD3YU89.
    BgeeiD3YU89.

    Family & Domainsi

    Sequence similaritiesi

    Contains AGC-kinase C-terminal domain.SAAS annotation
    Contains PH domain.SAAS annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117422.
    HOGENOMiHOG000015347.
    KOiK16308.
    OMAiMKAKDQG.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR000961. AGC-kinase_C.
    IPR001180. Citron.
    IPR017405. Citron_Rho-interacting_kinase.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR017892. Pkinase_C.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
    SMARTiSM00109. C1. 1 hit.
    SM00036. CNH. 1 hit.
    SM00233. PH. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS50219. CNH. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3YU89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG     50
    MLDALFALFE ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR 100
    SLVGCGHFAE VQVVREKATG DVYAMKIMKK KALLAQEQVS FFEEERNILS 150
    RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG DLLSLLNRYE DQLDESMIQF 200
    YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF GSAAKMNSNK 250
    VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT 300
    PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF 350
    EGLCCHPFFA RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV 400
    CQLSPSGFSG EELPFVGFSY SKALGYLGRS ESVVSSLDSP AKVSSMEKKL 450
    LIKSKELQDS QDKCHKMEQE MTRLHRRVSE VEAVLSQKEV ELKASETQRS 500
    LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD IREQSRKLQE 550
    IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR 600
    KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA 650
    STEATELLQN IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE 700
    NKVKRLETME RRENRLKDDI QTKSEQIQQM ADKILELEEK HREAQVSAQH 750
    LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK ESLENMMQRH EEEAHEKGKI 800
    LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ RNMKAQEEMI 850
    SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKS RLLELETRLR 900
    EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT 950
    ELEETTAEAE EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED 1000
    NAELNNQNFY LSKQLDEASG ANDEIVQLRS EVDHLRREIT EREMQLTSQK 1050
    QTMEALKTTC TMLEEQVLDL EALNDELLEK ERQWEAWRSV LGDEKSQFEC 1100
    RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE ILALQQALKE 1150
    QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL 1200
    QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK 1250
    VKMEGTISQQ TKLIDFLQAK MDQPAKKKKG LFSRRKEDPA LPTQVPLQYN 1300
    ELKLALEKEK ARCAELEEAL QKTRIELRSA REEAAHRKAT DHPHPSTPAT 1350
    ARQQIAMSAI VRSPEHQPSA MSLLAPPSSR RKESSTPEEF SRRLKERMHH 1400
    NIPHRFNVGL NMRATKCAVC LDTVHFGRQA SKCLECQVMC HPKCSTCLPA 1450
    TCGLPAEYAT HFTEAFCRDK MNSPGLQSKE PGSSLHLEGW MKVPRNNKRG 1500
    QQGWDRKYIV LEGSKVLIYD NEAREAGQRP VEEFELCLPD GDVSIHGAVG 1550
    ASELANTAKA DVPYILKMES HPHTTCWPGR TLYLLAPSFP DKQRWVTALE 1600
    SVVAGGRVSR EKAEADAKLL GNSLLKLEGD DRLDMNCTLP FSDQVVLVGT 1650
    EEGLYALNVL KNSLTHIPGI GAVFQIYIIK DLEKLLMIAG EERALCLVDV 1700
    KKVKQSLAQS HLPAQPDVSP NIFEAVKGCH LFAAGKIENS LCICAAMPSK 1750
    VVILRYNDNL SKYCIRKEIE TSEPCSCIHF TNYSILIGTN KFYEIDMKQY 1800
    TLDEFLDKND HSLAPAVFAS SSNSFPVSIV QANSAGQREE YLLCFHEFGV 1850
    FVDSYGRRSR TDDLKWSRLP LAFAYREPYL FVTHFNSLEV IEIQARSSLG 1900
    SPARAYLEIP NPRYLGPAIS SGAIYLASSY QDKLRVICCK GNLVKESGTE 1950
    QHRVPSTSRS SPNKRGPPTY NEHITKRVAS SPAPPEGPSH PREPSTPHRY 2000
    RDREGRTELR RDKSPGRPLE REKSPGRMLS TRRERSPGRL FEDSSRGRLP 2050
    AGAVRTPLSQ VNKVWDQSSV 2070
    Length:2,070
    Mass (Da):237,060
    Last modified:April 20, 2010 - v1
    Checksum:i79701BCB76A3308A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115795 Genomic DNA. No translation available.
    AC162461 Genomic DNA. No translation available.
    RefSeqiXP_006530203.1. XM_006530140.1.
    UniGeneiMm.426282.
    Mm.8321.

    Genome annotation databases

    EnsembliENSMUST00000102560; ENSMUSP00000099620; ENSMUSG00000029516.
    GeneIDi12704.
    KEGGimmu:12704.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115795 Genomic DNA. No translation available.
    AC162461 Genomic DNA. No translation available.
    RefSeqi XP_006530203.1. XM_006530140.1.
    UniGenei Mm.426282.
    Mm.8321.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102560 ; ENSMUSP00000099620 ; ENSMUSG00000029516 .
    GeneIDi 12704.
    KEGGi mmu:12704.

    Organism-specific databases

    CTDi 11113.
    MGIi MGI:105313. Cit.

    Phylogenomic databases

    GeneTreei ENSGT00750000117422.
    HOGENOMi HOG000015347.
    KOi K16308.
    OMAi MKAKDQG.

    Miscellaneous databases

    NextBioi 35548555.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D3YU89.
    Bgeei D3YU89.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR000961. AGC-kinase_C.
    IPR001180. Citron.
    IPR017405. Citron_Rho-interacting_kinase.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR017892. Pkinase_C.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
    SMARTi SM00109. C1. 1 hit.
    SM00036. CNH. 1 hit.
    SM00233. PH. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS50219. CNH. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiD3YU89_MOUSE
    AccessioniPrimary (citable) accession number: D3YU89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3