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D3YU89

- D3YU89_MOUSE

UniProt

D3YU89 - D3YU89_MOUSE

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Protein
Submitted name:

Citron Rho-interacting kinase

Gene

Cit

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: MGI
  4. small GTPase regulator activity Source: InterPro

GO - Biological processi

  1. dendrite development Source: MGI
  2. intracellular signal transduction Source: InterPro
  3. metaphase/anaphase transition of mitotic cell cycle Source: MGI
  4. mitotic sister chromatid segregation Source: MGI
  5. negative regulation of dendrite morphogenesis Source: MGI
  6. negative regulation of neuron differentiation Source: MGI
  7. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Citron Rho-interacting kinaseImported
Gene namesi
Name:CitImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:105313. Cit.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: MGI
  2. cytoplasm Source: MGI
  3. ruffle Source: MGI
  4. vacuole Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3YU89.
ExpressionAtlasiD3YU89. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotation
Contains PH domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118994.
HOGENOMiHOG000015347.
KOiK16308.
OMAiMKAKDQG.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR001180. Citron.
IPR017405. Citron_Rho-interacting_kinase.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YU89-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG
60 70 80 90 100
MLDALFALFE ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR
110 120 130 140 150
SLVGCGHFAE VQVVREKATG DVYAMKIMKK KALLAQEQVS FFEEERNILS
160 170 180 190 200
RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG DLLSLLNRYE DQLDESMIQF
210 220 230 240 250
YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF GSAAKMNSNK
260 270 280 290 300
VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT
310 320 330 340 350
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF
360 370 380 390 400
EGLCCHPFFA RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV
410 420 430 440 450
CQLSPSGFSG EELPFVGFSY SKALGYLGRS ESVVSSLDSP AKVSSMEKKL
460 470 480 490 500
LIKSKELQDS QDKCHKMEQE MTRLHRRVSE VEAVLSQKEV ELKASETQRS
510 520 530 540 550
LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD IREQSRKLQE
560 570 580 590 600
IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR
610 620 630 640 650
KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA
660 670 680 690 700
STEATELLQN IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE
710 720 730 740 750
NKVKRLETME RRENRLKDDI QTKSEQIQQM ADKILELEEK HREAQVSAQH
760 770 780 790 800
LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK ESLENMMQRH EEEAHEKGKI
810 820 830 840 850
LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ RNMKAQEEMI
860 870 880 890 900
SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKS RLLELETRLR
910 920 930 940 950
EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT
960 970 980 990 1000
ELEETTAEAE EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED
1010 1020 1030 1040 1050
NAELNNQNFY LSKQLDEASG ANDEIVQLRS EVDHLRREIT EREMQLTSQK
1060 1070 1080 1090 1100
QTMEALKTTC TMLEEQVLDL EALNDELLEK ERQWEAWRSV LGDEKSQFEC
1110 1120 1130 1140 1150
RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE ILALQQALKE
1160 1170 1180 1190 1200
QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL
1210 1220 1230 1240 1250
QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK
1260 1270 1280 1290 1300
VKMEGTISQQ TKLIDFLQAK MDQPAKKKKG LFSRRKEDPA LPTQVPLQYN
1310 1320 1330 1340 1350
ELKLALEKEK ARCAELEEAL QKTRIELRSA REEAAHRKAT DHPHPSTPAT
1360 1370 1380 1390 1400
ARQQIAMSAI VRSPEHQPSA MSLLAPPSSR RKESSTPEEF SRRLKERMHH
1410 1420 1430 1440 1450
NIPHRFNVGL NMRATKCAVC LDTVHFGRQA SKCLECQVMC HPKCSTCLPA
1460 1470 1480 1490 1500
TCGLPAEYAT HFTEAFCRDK MNSPGLQSKE PGSSLHLEGW MKVPRNNKRG
1510 1520 1530 1540 1550
QQGWDRKYIV LEGSKVLIYD NEAREAGQRP VEEFELCLPD GDVSIHGAVG
1560 1570 1580 1590 1600
ASELANTAKA DVPYILKMES HPHTTCWPGR TLYLLAPSFP DKQRWVTALE
1610 1620 1630 1640 1650
SVVAGGRVSR EKAEADAKLL GNSLLKLEGD DRLDMNCTLP FSDQVVLVGT
1660 1670 1680 1690 1700
EEGLYALNVL KNSLTHIPGI GAVFQIYIIK DLEKLLMIAG EERALCLVDV
1710 1720 1730 1740 1750
KKVKQSLAQS HLPAQPDVSP NIFEAVKGCH LFAAGKIENS LCICAAMPSK
1760 1770 1780 1790 1800
VVILRYNDNL SKYCIRKEIE TSEPCSCIHF TNYSILIGTN KFYEIDMKQY
1810 1820 1830 1840 1850
TLDEFLDKND HSLAPAVFAS SSNSFPVSIV QANSAGQREE YLLCFHEFGV
1860 1870 1880 1890 1900
FVDSYGRRSR TDDLKWSRLP LAFAYREPYL FVTHFNSLEV IEIQARSSLG
1910 1920 1930 1940 1950
SPARAYLEIP NPRYLGPAIS SGAIYLASSY QDKLRVICCK GNLVKESGTE
1960 1970 1980 1990 2000
QHRVPSTSRS SPNKRGPPTY NEHITKRVAS SPAPPEGPSH PREPSTPHRY
2010 2020 2030 2040 2050
RDREGRTELR RDKSPGRPLE REKSPGRMLS TRRERSPGRL FEDSSRGRLP
2060 2070
AGAVRTPLSQ VNKVWDQSSV
Length:2,070
Mass (Da):237,060
Last modified:April 20, 2010 - v1
Checksum:i79701BCB76A3308A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115795 Genomic DNA. No translation available.
AC162461 Genomic DNA. No translation available.
RefSeqiXP_006530203.1. XM_006530140.1.
UniGeneiMm.426282.
Mm.8321.

Genome annotation databases

EnsembliENSMUST00000102560; ENSMUSP00000099620; ENSMUSG00000029516.
GeneIDi12704.
KEGGimmu:12704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115795 Genomic DNA. No translation available.
AC162461 Genomic DNA. No translation available.
RefSeqi XP_006530203.1. XM_006530140.1.
UniGenei Mm.426282.
Mm.8321.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102560 ; ENSMUSP00000099620 ; ENSMUSG00000029516 .
GeneIDi 12704.
KEGGi mmu:12704.

Organism-specific databases

CTDi 11113.
MGIi MGI:105313. Cit.

Phylogenomic databases

GeneTreei ENSGT00760000118994.
HOGENOMi HOG000015347.
KOi K16308.
OMAi MKAKDQG.

Miscellaneous databases

NextBioi 35548555.
SOURCEi Search...

Gene expression databases

Bgeei D3YU89.
ExpressionAtlasi D3YU89. baseline and differential.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR001180. Citron.
IPR017405. Citron_Rho-interacting_kinase.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMARTi SM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3YU89_MOUSE
AccessioniPrimary (citable) accession number: D3YU89
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3