ID   D3YU40_MOUSE            Unreviewed;       158 AA.
AC   D3YU40;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   RecName: Full=Insulin-like growth factor-binding protein 2 {ECO:0000256|ARBA:ARBA00013676};
GN   Name=Igfbp2 {ECO:0000313|Ensembl:ENSMUSP00000112706.2,
GN   ECO:0000313|MGI:MGI:96437};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000112706.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000112706.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112706.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000112706.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112706.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   RefSeq; NP_001297588.1; NM_001310659.1.
DR   AlphaFoldDB; D3YU40; -.
DR   SMR; D3YU40; -.
DR   EPD; D3YU40; -.
DR   MaxQB; D3YU40; -.
DR   PeptideAtlas; D3YU40; -.
DR   ProteomicsDB; 326826; -.
DR   Antibodypedia; 11351; 512 antibodies from 37 providers.
DR   DNASU; 16008; -.
DR   Ensembl; ENSMUST00000120564.2; ENSMUSP00000112706.2; ENSMUSG00000039323.19.
DR   GeneID; 16008; -.
DR   AGR; MGI:96437; -.
DR   CTD; 3485; -.
DR   MGI; MGI:96437; Igfbp2.
DR   VEuPathDB; HostDB:ENSMUSG00000039323; -.
DR   GeneTree; ENSGT00940000158542; -.
DR   HOGENOM; CLU_070833_3_2_1; -.
DR   OrthoDB; 5394492at2759; -.
DR   BioGRID-ORCS; 16008; 2 hits in 79 CRISPR screens.
DR   ChiTaRS; Igfbp2; mouse.
DR   Proteomes; UP000000589; Chromosome 1.
DR   Bgee; ENSMUSG00000039323; Expressed in choroid plexus of fourth ventricle and 281 other cell types or tissues.
DR   ExpressionAtlas; D3YU40; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR   InterPro; IPR012210; IGFBP-2.
DR   InterPro; IPR022321; IGFBP_1-6_chordata.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR   PANTHER; PTHR11551:SF5; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   PRINTS; PR01976; IGFBPFAMILY.
DR   PRINTS; PR01978; IGFBPFAMILY2.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Proteomics identification {ECO:0007829|EPD:D3YU40,
KW   ECO:0007829|MaxQB:D3YU40};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          57..139
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   158 AA;  17706 MW;  E9399437D961AD28 CRC64;
     MNMLGGGSSA GRKPLKSGMK ELAVFREKVN EQHRQMGKGA KHLSLEEPKK LRPPPARTPC
     QQELDQVLER ISTMRLPDDR GPLEHLYSLH IPNCDKHGRY NLKQCKMSLN GQRGECWCVN
     PNTGKPIQGA PTIRGDPECH LFYNEQQETG GAHAQSVQ
//