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Protein
Submitted name:

Solute carrier family 12 (Potassium/chloride transporters), member 8, isoform CRA_c

Gene

Slc12a8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 12 (Potassium/chloride transporters), member 8, isoform CRA_cImported
Submitted name:
Solute carrier family 12 member 8Imported
Gene namesi
Name:Slc12a8Imported
ORF Names:mCG_130131Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443672. Slc12a8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20
Transmembranei60 – 82HelicalSequence analysisAdd BLAST23
Transmembranei114 – 140HelicalSequence analysisAdd BLAST27
Transmembranei332 – 353HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000035506.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 161AA_permeaseInterPro annotationAdd BLAST160

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000045198.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3YTS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFNMGGDL RDPADSVPLG SLAAVGVSWF LYIIFAFLLG AVCTREALRS
60 70 80 90 100
DFLIAEKVSL VGFLFLLGLY ISSLASCMGG LYGAPRILQC IAQDKVIPAL
110 120 130 140 150
AFLANGKGPN KTPVAAICLT SLVTMAFVLV GQVNVLAPVV TINFMLTYIM
160 170 180 190 200
VDYSYFALSM AHCGLAPSPE PVPRQGPDTL HCSEHLLQDR APSYGSDVPA
210 220 230 240 250
RSLSEGTLLE FTKDMDQFLQ PIEELESRQL GSREGNNPKN QKRKGKKGAK
260 270 280 290 300
QTLQDSFLLD PGSPLSFPTR TSERLSVAFC GEQESYQKQQ TSRSESHDHL
310 320 330 340 350
VPDLRNQPRV NREDFFLKCR LQEQEIQRRP SVFYACMCNP WVSLLGALAS
360 370 380 390 400
LLIMFVIQWL YTLASMGVAA LVYFYIGQAS PGLYLGSASN FSFFQWMKSF
410 420
LVPSCRSVPT GAGTRRDECP RGWGGA
Length:426
Mass (Da):46,750
Last modified:April 20, 2010 - v1
Checksum:i4016A810E9A8942F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97844.1.
UniGeneiMm.35253.

Genome annotation databases

EnsembliENSMUST00000117134; ENSMUSP00000112925; ENSMUSG00000035506.
UCSCiuc007zaf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121570 Genomic DNA. No translation available.
AC127412 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97844.1.
UniGeneiMm.35253.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117134; ENSMUSP00000112925; ENSMUSG00000035506.
UCSCiuc007zaf.1. mouse.

Organism-specific databases

CTDi84561.
MGIiMGI:2443672. Slc12a8.

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000045198.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035506.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3YTS8_MOUSE
AccessioniPrimary (citable) accession number: D3YTS8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.