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D3YTK6

- D3YTK6_MOUSE

UniProt

D3YTK6 - D3YTK6_MOUSE

Protein
Submitted name:

NAD-dependent protein deacetylase sirtuin-3

Gene

Sirt3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 2 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. NAD+ binding Source: InterPro
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: MGI

    GO - Biological processi

    1. histone H3 deacetylation Source: GOC
    2. protein deacetylation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NAD-dependent protein deacetylase sirtuin-3Imported
    Gene namesi
    Name:Sirt3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1927665. Sirt3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. membrane Source: MGI
    3. mitochondrion Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiD3YTK6.
    BgeeiD3YTK6.

    Structurei

    3D structure databases

    ProteinModelPortaliD3YTK6.
    SMRiD3YTK6. Positions 57-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00740000115546.
    HOGENOMiHOG000085952.
    PhylomeDBiD3YTK6.

    Family and domain databases

    Gene3Di3.30.1600.10. 2 hits.
    3.40.50.1220. 3 hits.
    InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
    IPR003000. Sirtuin.
    IPR026591. Sirtuin_cat_small_dom.
    IPR026590. Ssirtuin_cat_dom.
    [Graphical view]
    PANTHERiPTHR11085. PTHR11085. 1 hit.
    PfamiPF02146. SIR2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52467. SSF52467. 1 hit.
    PROSITEiPS50305. SIRTUIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D3YTK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALDPLGAVV LQSIMALSGR LALAALRLWG PGGGRRPISL CVGASGGFGG    50
    GGSSEKKFSL QDVAELLRTR ACSRVVVMVG AGISTPSGIP DFRSPGSGLY 100
    SNLQQYDIPY PEAIFELGFF FHNPKPFFML AKELYPGHYR PNVTHYFLRL 150
    LHDKELLLRL YTQNIDGLER ASGIPASKLV EAHGTFVTAT CTVCRRSFPG 200
    EDIWADVMAD RVPRCPVCTG VVKPDIVFFG EQLPARFLLH MADFALADLL 250
    LILGTSLE 258
    Length:258
    Mass (Da):28,029
    Last modified:April 5, 2011 - v2
    Checksum:iF5983F76F1FA157B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei258 – 2581Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC107815 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000147331; ENSMUSP00000121151; ENSMUSG00000025486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC107815 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D3YTK6.
    SMRi D3YTK6. Positions 57-258.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000147331 ; ENSMUSP00000121151 ; ENSMUSG00000025486 .

    Organism-specific databases

    MGIi MGI:1927665. Sirt3.

    Phylogenomic databases

    GeneTreei ENSGT00740000115546.
    HOGENOMi HOG000085952.
    PhylomeDBi D3YTK6.

    Miscellaneous databases

    ChiTaRSi SIRT3. mouse.
    NextBioi 35548408.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D3YTK6.
    Bgeei D3YTK6.

    Family and domain databases

    Gene3Di 3.30.1600.10. 2 hits.
    3.40.50.1220. 3 hits.
    InterProi IPR029035. DHS-like_NAD/FAD-binding_dom.
    IPR003000. Sirtuin.
    IPR026591. Sirtuin_cat_small_dom.
    IPR026590. Ssirtuin_cat_dom.
    [Graphical view ]
    PANTHERi PTHR11085. PTHR11085. 1 hit.
    Pfami PF02146. SIR2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52467. SSF52467. 1 hit.
    PROSITEi PS50305. SIRTUIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiD3YTK6_MOUSE
    AccessioniPrimary (citable) accession number: D3YTK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 37 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3