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D3YTK6

- D3YTK6_MOUSE

UniProt

D3YTK6 - D3YTK6_MOUSE

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Protein
Submitted name:

NAD-dependent protein deacetylase sirtuin-3

Gene

Sirt3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. NAD+ binding Source: InterPro
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: MGI

GO - Biological processi

  1. histone H3 deacetylation Source: GOC
  2. protein deacetylation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent protein deacetylase sirtuin-3Imported
Gene namesi
Name:Sirt3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1927665. Sirt3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane Source: MGI
  3. mitochondrion Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3YTK6.
ExpressionAtlasiD3YTK6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3YTK6.
SMRiD3YTK6. Positions 57-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00740000115546.
HOGENOMiHOG000085952.
PhylomeDBiD3YTK6.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3YTK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALDPLGAVV LQSIMALSGR LALAALRLWG PGGGRRPISL CVGASGGFGG
60 70 80 90 100
GGSSEKKFSL QDVAELLRTR ACSRVVVMVG AGISTPSGIP DFRSPGSGLY
110 120 130 140 150
SNLQQYDIPY PEAIFELGFF FHNPKPFFML AKELYPGHYR PNVTHYFLRL
160 170 180 190 200
LHDKELLLRL YTQNIDGLER ASGIPASKLV EAHGTFVTAT CTVCRRSFPG
210 220 230 240 250
EDIWADVMAD RVPRCPVCTG VVKPDIVFFG EQLPARFLLH MADFALADLL

LILGTSLE
Length:258
Mass (Da):28,029
Last modified:April 5, 2011 - v2
Checksum:iF5983F76F1FA157B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei258 – 2581Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107815 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000147331; ENSMUSP00000121151; ENSMUSG00000025486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107815 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali D3YTK6.
SMRi D3YTK6. Positions 57-258.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000147331 ; ENSMUSP00000121151 ; ENSMUSG00000025486 .

Organism-specific databases

MGIi MGI:1927665. Sirt3.

Phylogenomic databases

GeneTreei ENSGT00740000115546.
HOGENOMi HOG000085952.
PhylomeDBi D3YTK6.

Miscellaneous databases

ChiTaRSi SIRT3. mouse.
NextBioi 35548408.
SOURCEi Search...

Gene expression databases

Bgeei D3YTK6.
ExpressionAtlasi D3YTK6. baseline and differential.

Family and domain databases

Gene3Di 3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProi IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR026590. Ssirtuin_cat_dom.
[Graphical view ]
PANTHERi PTHR11085. PTHR11085. 1 hit.
Pfami PF02146. SIR2. 1 hit.
[Graphical view ]
SUPFAMi SSF52467. SSF52467. 1 hit.
PROSITEi PS50305. SIRTUIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD3YTK6_MOUSE
AccessioniPrimary (citable) accession number: D3YTK6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3