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Protein

Pantothenate synthetase

Gene

panC

Organism
Staphylococcus staphylolyticus
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton donorUniRule annotation1
Binding sitei64Beta-alanineUniRule annotation1
Binding sitei64PantoateUniRule annotation1
Binding sitei156PantoateUniRule annotation1
Binding sitei179ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 40ATPUniRule annotation8
Nucleotide bindingi150 – 153ATPUniRule annotation4
Nucleotide bindingi187 – 190ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Encoded oniPlasmid pACK1Imported
Plasmid pACK3Imported
OrganismiStaphylococcus staphylolyticusImported
Taxonomic identifieri1287 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

D3X7K3:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiView protein in InterPro
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiView protein in Pfam
PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

D3X7K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMTKVIQTV AEMQHITQEL KRTGKTIGFV PTMGALHEGH LSMMRRSVED
60 70 80 90 100
NDVTVISIFV NPLQFGPNED FDDYPRQIDQ DVALVEAINV DYVFHPTVEE
110 120 130 140 150
MYPNELSITL KVGRLAEVLE GVQRPGHFNG VVTVVNKLFN IVNPDKAYFG
160 170 180 190 200
KKDAQQLAIV EKMVEDFNHP IEIVGVDIVR EADGLARSSR NIYLTDDERQ
210 220 230 240 250
EAVHLSKSLE LAQTLYNQGE RRSHIIVGEI KGYLTEHTRG HIDKVAIYSY
260 270 280
PGLEVVTEIQ GQIFISLAVK FSKARVIDNI ILGSES
Length:286
Mass (Da):32,174
Last modified:April 20, 2010 - v1
Checksum:iEE7C69A716B8DA16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU228571 Genomic DNA. Translation: ADD24875.1.
GU228572 Genomic DNA. Translation: ADD24924.1.
RefSeqiWP_013012268.1. NC_013945.1.
YP_003505743.1. NC_013944.1.
YP_003505792.1. NC_013945.1.

Genome annotation databases

GeneIDi8864991.
8865039.

Similar proteinsi

Entry informationi

Entry nameiD3X7K3_STAST
AccessioniPrimary (citable) accession number: D3X7K3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

PlasmidImported