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D3V3H5 (D3V3H5_XENBS) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-erythrose-4-phosphate dehydrogenase HAMAP-Rule MF_01640

Short name=E4PDH HAMAP-Rule MF_01640
EC=1.2.1.72 HAMAP-Rule MF_01640
Gene names
Name:epd HAMAP-Rule MF_01640 EMBL CBJ82204.1
Ordered Locus Names:XBJ1_3081 EMBL CBJ82204.1
OrganismXenorhabdus bovienii (strain SS-2004) [Complete proteome] [HAMAP] EMBL CBJ82204.1
Taxonomic identifier406818 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate By similarity. HAMAP-Rule MF_01640 SAAS SAAS020830

Catalytic activity

D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH. HAMAP-Rule MF_01640 SAAS SAAS020830

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5. HAMAP-Rule MF_01640 SAAS SAAS020830

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01640 SAAS SAAS006422

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01640 SAAS SAAS006422.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily. HAMAP-Rule MF_01640

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 132NAD By similarity HAMAP-Rule MF_01640
Region154 – 1563Substrate binding By similarity HAMAP-Rule MF_01640
Region213 – 2142Substrate binding By similarity HAMAP-Rule MF_01640

Sites

Active site1551Nucleophile By similarity HAMAP-Rule MF_01640 PIRSR PIRSR000149-1
Binding site2001Substrate By similarity HAMAP-Rule MF_01640
Binding site2361Substrate By similarity HAMAP-Rule MF_01640
Binding site3181NAD By similarity HAMAP-Rule MF_01640
Site1821Activates thiol group during catalysis By similarity HAMAP-Rule MF_01640 PIRSR PIRSR000149-4

Sequences

Sequence LengthMass (Da)Tools
D3V3H5 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: E99A3A9F4AD66675

FASTA33936,855
        10         20         30         40         50         60 
MTIRIAINGF GRIGRSILRA LYESGRQTEI SVIAINELAD AEGIAHLLKY DSSHGRFAWD 

        70         80         90        100        110        120 
VRLNNNLLLV GDDSIRLFHQ PDISALPWKE LGIDIVLDCT GKYGDRADGE AHIASGAKKV 

       130        140        150        160        170        180 
LFSHPGGNDL DATVVYGVNH HELVAEDCIV SNASCTTNCI IPIIKLLDDA FNIESGTVTT 

       190        200        210        220        230        240 
IHASMNDQPV IDAYHSDLRR TRAASQSIIP VDTKLSAGIT RIFPKFSDRF EAISVRVPTI 

       250        260        270        280        290        300 
NVTAIDLSVT VSAAVDVGDV NQLLQESAGS SFRGIVDYTD LPLVSTDFNH DPHSAIVDGT 

       310        320        330 
QTRVSGNHLI KTLVWCDNEW GFANRMLDTT LVMAATGFK 

« Hide

References

[1]"Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS-2004.
[2]"The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus: convergent lifestyles from divergent genomes."
Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E., Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J. expand/collapse author list , Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.
PLoS ONE 6:e27909-e27909(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS-2004 EMBL CBJ82204.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN667741 Genomic DNA. Translation: CBJ82204.1.
RefSeqYP_003468968.1. NC_013892.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBJ82204; CBJ82204; XBJ1_3081.
GeneID8832690.
KEGGxbo:XBJ1_3081.
PATRIC35300847. VBIXenBov95754_2773.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000071679.
KOK03472.

Enzyme and pathway databases

BioCycXBOV406818:GHLH-3063-MONOMER.
UniPathwayUPA00244; UER00309.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01640. E4P_dehydrog.
InterProIPR006422. E4P_DH_bac.
IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR10836. PTHR10836. 1 hit.
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
PRINTSPR00078. G3PDHDRGNASE.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01532. E4PD_g-proteo. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3V3H5_XENBS
AccessionPrimary (citable) accession number: D3V3H5
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)