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D3V3H5

- D3V3H5_XENBS

UniProt

D3V3H5 - D3V3H5_XENBS

Protein

D-erythrose-4-phosphate dehydrogenase

Gene

epd

Organism
Xenorhabdus bovienii (strain SS-2004)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.UniRule annotationSAAS annotation

    Catalytic activityi

    D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei155 – 1551NucleophileUniRule annotation
    Sitei182 – 1821Activates thiol group during catalysisUniRule annotation
    Binding sitei200 – 2001SubstrateUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation
    Binding sitei318 – 3181NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 132NADUniRule annotation

    GO - Molecular functioni

    1. erythrose-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Pyridoxine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciXBOV406818:GHLH-3063-MONOMER.
    UniPathwayiUPA00244; UER00309.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-erythrose-4-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.72UniRule annotation)
    Short name:
    E4PDHUniRule annotation
    Gene namesi
    Name:epdUniRule annotationImported
    Ordered Locus Names:XBJ1_3081Imported
    OrganismiXenorhabdus bovienii (strain SS-2004)Imported
    Taxonomic identifieri406818 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus
    ProteomesiUP000002045: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni154 – 1563Substrate bindingUniRule annotation
    Regioni213 – 2142Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000071679.
    KOiK03472.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01640. E4P_dehydrog.
    InterProiIPR006422. E4P_DH_bac.
    IPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR10836. PTHR10836. 1 hit.
    PfamiPF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000149. GAP_DH. 1 hit.
    PRINTSiPR00078. G3PDHDRGNASE.
    SMARTiSM00846. Gp_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01532. E4PD_g-proteo. 1 hit.
    PROSITEiPS00071. GAPDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3V3H5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIRIAINGF GRIGRSILRA LYESGRQTEI SVIAINELAD AEGIAHLLKY    50
    DSSHGRFAWD VRLNNNLLLV GDDSIRLFHQ PDISALPWKE LGIDIVLDCT 100
    GKYGDRADGE AHIASGAKKV LFSHPGGNDL DATVVYGVNH HELVAEDCIV 150
    SNASCTTNCI IPIIKLLDDA FNIESGTVTT IHASMNDQPV IDAYHSDLRR 200
    TRAASQSIIP VDTKLSAGIT RIFPKFSDRF EAISVRVPTI NVTAIDLSVT 250
    VSAAVDVGDV NQLLQESAGS SFRGIVDYTD LPLVSTDFNH DPHSAIVDGT 300
    QTRVSGNHLI KTLVWCDNEW GFANRMLDTT LVMAATGFK 339
    Length:339
    Mass (Da):36,855
    Last modified:April 20, 2010 - v1
    Checksum:iE99A3A9F4AD66675
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN667741 Genomic DNA. Translation: CBJ82204.1.
    RefSeqiWP_012989467.1. NC_013892.1.
    YP_003468968.1. NC_013892.1.

    Genome annotation databases

    EnsemblBacteriaiCBJ82204; CBJ82204; XBJ1_3081.
    GeneIDi8832690.
    KEGGixbo:XBJ1_3081.
    PATRICi35300847. VBIXenBov95754_2773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN667741 Genomic DNA. Translation: CBJ82204.1 .
    RefSeqi WP_012989467.1. NC_013892.1.
    YP_003468968.1. NC_013892.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBJ82204 ; CBJ82204 ; XBJ1_3081 .
    GeneIDi 8832690.
    KEGGi xbo:XBJ1_3081.
    PATRICi 35300847. VBIXenBov95754_2773.

    Phylogenomic databases

    HOGENOMi HOG000071679.
    KOi K03472.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00309 .
    BioCyci XBOV406818:GHLH-3063-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01640. E4P_dehydrog.
    InterProi IPR006422. E4P_DH_bac.
    IPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10836. PTHR10836. 1 hit.
    Pfami PF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000149. GAP_DH. 1 hit.
    PRINTSi PR00078. G3PDHDRGNASE.
    SMARTi SM00846. Gp_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01532. E4PD_g-proteo. 1 hit.
    PROSITEi PS00071. GAPDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
      Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS-2004Imported.
    2. "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus: convergent lifestyles from divergent genomes."
      Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E., Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.
      , Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.
      PLoS ONE 6:e27909-e27909(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS-2004Imported.

    Entry informationi

    Entry nameiD3V3H5_XENBS
    AccessioniPrimary (citable) accession number: D3V3H5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3