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Protein

D-erythrose-4-phosphate dehydrogenase

Gene

epd

Organism
Xenorhabdus bovienii (strain SS-2004)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.UniRule annotationSAAS annotation

Catalytic activityi

D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei155 – 1551NucleophileUniRule annotation
Sitei182 – 1821Activates thiol group during catalysisUniRule annotation
Binding sitei200 – 2001SubstrateUniRule annotation
Binding sitei236 – 2361SubstrateUniRule annotation
Binding sitei318 – 3181NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 132NADUniRule annotation

GO - Molecular functioni

  1. erythrose-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Pyridoxine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciXBOV406818:GHLH-3063-MONOMER.
UniPathwayiUPA00244; UER00309.

Names & Taxonomyi

Protein namesi
Recommended name:
D-erythrose-4-phosphate dehydrogenaseUniRule annotationSAAS annotation (EC:1.2.1.72UniRule annotationSAAS annotation)
Short name:
E4PDHUniRule annotation
Gene namesi
Name:epdUniRule annotationImported
Ordered Locus Names:XBJ1_3081Imported
OrganismiXenorhabdus bovienii (strain SS-2004)Imported
Taxonomic identifieri406818 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus
ProteomesiUP000002045 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 1563Substrate bindingUniRule annotation
Regioni213 – 2142Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000071679.
KOiK03472.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01640. E4P_dehydrog.
InterProiIPR006422. E4P_DH_bac.
IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10836. PTHR10836. 1 hit.
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
PRINTSiPR00078. G3PDHDRGNASE.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01532. E4PD_g-proteo. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3V3H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIRIAINGF GRIGRSILRA LYESGRQTEI SVIAINELAD AEGIAHLLKY
60 70 80 90 100
DSSHGRFAWD VRLNNNLLLV GDDSIRLFHQ PDISALPWKE LGIDIVLDCT
110 120 130 140 150
GKYGDRADGE AHIASGAKKV LFSHPGGNDL DATVVYGVNH HELVAEDCIV
160 170 180 190 200
SNASCTTNCI IPIIKLLDDA FNIESGTVTT IHASMNDQPV IDAYHSDLRR
210 220 230 240 250
TRAASQSIIP VDTKLSAGIT RIFPKFSDRF EAISVRVPTI NVTAIDLSVT
260 270 280 290 300
VSAAVDVGDV NQLLQESAGS SFRGIVDYTD LPLVSTDFNH DPHSAIVDGT
310 320 330
QTRVSGNHLI KTLVWCDNEW GFANRMLDTT LVMAATGFK
Length:339
Mass (Da):36,855
Last modified:April 20, 2010 - v1
Checksum:iE99A3A9F4AD66675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667741 Genomic DNA. Translation: CBJ82204.1.
RefSeqiYP_003468968.1. NC_013892.1.

Genome annotation databases

EnsemblBacteriaiCBJ82204; CBJ82204; XBJ1_3081.
KEGGixbo:XBJ1_3081.
PATRICi35300847. VBIXenBov95754_2773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667741 Genomic DNA. Translation: CBJ82204.1.
RefSeqiYP_003468968.1. NC_013892.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBJ82204; CBJ82204; XBJ1_3081.
KEGGixbo:XBJ1_3081.
PATRICi35300847. VBIXenBov95754_2773.

Phylogenomic databases

HOGENOMiHOG000071679.
KOiK03472.

Enzyme and pathway databases

UniPathwayiUPA00244; UER00309.
BioCyciXBOV406818:GHLH-3063-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01640. E4P_dehydrog.
InterProiIPR006422. E4P_DH_bac.
IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10836. PTHR10836. 1 hit.
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
PRINTSiPR00078. G3PDHDRGNASE.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01532. E4PD_g-proteo. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
    Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS-2004Imported.
  2. "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus: convergent lifestyles from divergent genomes."
    Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E., Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.
    , Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.
    PLoS ONE 6:e27909-e27909(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS-2004Imported.

Entry informationi

Entry nameiD3V3H5_XENBS
AccessioniPrimary (citable) accession number: D3V3H5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 29, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.