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D3V0W1 (D3V0W1_XENBS) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyrrolidone-carboxylate peptidase HAMAP-Rule MF_00417

EC=3.4.19.3 HAMAP-Rule MF_00417
Alternative name(s):
5-oxoprolyl-peptidase HAMAP-Rule MF_00417
Pyroglutamyl-peptidase I HAMAP-Rule MF_00417
Gene names
Name:pcp HAMAP-Rule MF_00417
Ordered Locus Names:XBJ1_1667 EMBL CBJ80793.1
OrganismXenorhabdus bovienii (strain SS-2004) [Complete proteome] [HAMAP] EMBL CBJ80793.1
Taxonomic identifier406818 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity. HAMAP-Rule MF_00417 SAAS SAAS000816

Catalytic activity

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. HAMAP-Rule MF_00417 SAAS SAAS000816

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00417

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00417 SAAS SAAS000816.

Sequence similarities

Belongs to the peptidase C15 family. HAMAP-Rule MF_00417

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region117 – 1204Phosphate 1 binding

Sites

Active site801 By similarity HAMAP-Rule MF_00417
Active site1431 By similarity HAMAP-Rule MF_00417
Active site1671 By similarity HAMAP-Rule MF_00417
Binding site181Chloride 1
Binding site521Chloride 3 PDB 4HPS
Binding site701Chloride 1; via amide nitrogen
Binding site721Chloride 2; via amide nitrogen PDB 4HPS
Binding site901Chloride 5; via amide nitrogen PDB 4HPS
Binding site901Chloride 6; via amide nitrogen PDB 4HPS
Binding site1191Chloride 7 PDB 4HPS
Binding site1361Chloride 8; via amide nitrogen PDB 4HPS
Binding site1401Chloride 10; via amide nitrogen PDB 4HPS
Binding site1401Chloride 9; via amide nitrogen PDB 4HPS
Binding site1721Phosphate 2
Binding site1821Chloride 4; via amide nitrogen PDB 4HPS
Binding site1861Chloride 11; via amide nitrogen PDB 4HPS
Binding site1861Chloride 12; via amide nitrogen PDB 4HPS
Binding site1861Phosphate 2; via amide nitrogen
Binding site2051Phosphate 1; via carbonyl oxygen

Sequences

Sequence LengthMass (Da)Tools
D3V0W1 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 6EE07B0220E6B059

FASTA21522,980
        10         20         30         40         50         60 
MKTILVTAFD PFGGEAINPS WEAIKPLQGS QVFGANIEIC QIPCIFDTSL EHLYAAVDKY 

        70         80         90        100        110        120 
QPELVISVGQ AGGRTNITVE RVAININDAR IPDNAGNQPI DTPVIVDGPA AYFSRLPIKT 

       130        140        150        160        170        180 
MVNALNTAGI PASVSQTAGT FVCNHVMYGL LHYLAQNTPS VRGGFIHVPY LPEQAVKDGN 

       190        200        210 
QSSMTLMLMT LALKIAIETA WKNTSDIAVT GGATH 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS-2004.
[2]"Crystal Structure of a Pyrrolidone-carboxylate peptidase 1 (target ID NYSGRC-012831) from Xenorhabdus bovienii SS-2004 (CASP Target)."
Ghosh A., Bhoshle R., Toro R., Gizzi A., Hillerich B., Seidel R., Almo S.C., New York Structural Genomics Research Consortium
Submitted (SEP-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH CHLORIDE AND PHOSPHATE.
[3]"Crystal Structure of a Pyrrolidone-carboxylate peptidase 1 (target ID NYSGRC-012831) from Xenorhabdus bovienii SS-2004 in space group P21."
Ghosh A., Ahmed A., Banu R., Bhoshle R., Bonanno J., Chamala S., Chowdhury S., Fiser A, Glenn A.S., Hillerich B., Khafizov K., Lafleur J., Love J.D., Seidel R., Stead M., Toro R., Almo S.C.
Submitted (OCT-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 1-206 IN COMPLEX WITH CHLORIDE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN667741 Genomic DNA. Translation: CBJ80793.1.
RefSeqYP_003467573.1. NC_013892.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GXHX-ray2.70A/B/C/D1-215[»]
4HPSX-ray1.55A/B/C/D1-206[»]
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC15.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBJ80793; CBJ80793; XBJ1_1667.
GeneID8831279.
KEGGxbo:XBJ1_1667.
PATRIC35298287. VBIXenBov95754_1510.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000242641.
KOK01304.

Enzyme and pathway databases

BioCycXBOV406818:GHLH-1652-MONOMER.

Family and domain databases

Gene3D3.40.630.20. 1 hit.
HAMAPMF_00417. Pyrrolid_peptidase.
InterProIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view]
PANTHERPTHR23402. PTHR23402. 1 hit.
PfamPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSPR00706. PYROGLUPTASE.
SUPFAMSSF53182. SSF53182. 1 hit.
TIGRFAMsTIGR00504. pyro_pdase. 1 hit.
PROSITEPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3V0W1_XENBS
AccessionPrimary (citable) accession number: D3V0W1
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 19, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)