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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Xenorhabdus bovienii (strain SS-2004)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Metal cation 1UniRule annotation1
Metal bindingi10Metal cation 1UniRule annotation1
Binding sitei10cAMPUniRule annotation1
Metal bindingi52Metal cation 1UniRule annotation1
Metal bindingi52Metal cation 2UniRule annotation1
Binding sitei52cAMPUniRule annotation1
Metal bindingi82Metal cation 2UniRule annotation1
Metal bindingi154Metal cation 2UniRule annotation1
Metal bindingi192Metal cation 2UniRule annotation1
Metal bindingi194Metal cation 1UniRule annotation1
Binding sitei194cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 83cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXBOV406818:G1GIZ-845-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:XBJ1_0953
OrganismiXenorhabdus bovienii (strain SS-2004)
Taxonomic identifieri406818 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeXenorhabdus
Proteomesi
  • UP000002045 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133841 – 2473',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST247

Interactioni

Protein-protein interaction databases

STRINGi406818.XBJ1_0953

Structurei

3D structure databases

ProteinModelPortaliD3UX49
SMRiD3UX49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG Bacteria
COG1409 LUCA
OMAiIPVFWIP
OrthoDBiPOG091H05L5

Family and domain databases

Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

D3UX49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVNLTDIH LTRNRDKKLF DVNTYDNFDF VCEEIHRIQN LTEIELIIVS
60 70 80 90 100
GDIANDGDVE AYRYFLNKME SLKTPYISIL GNHDLNKNFE ITLAEEKPKY
110 120 130 140 150
IISSREYNND NWYITAVDTV VEGEDYGFIT QDNLAELERK IITNSNFNIA
160 170 180 190 200
IFMHHHAMPV GTPIVDSCML NNAKAILELC EKHRVKFIGS GHAHTPRVWH
210 220 230 240
HNNMTACVSP AVSFQWLSGT NTVKISKGFG FNVIDFSPDL SITSCIY
Length:247
Mass (Da):28,252
Last modified:April 20, 2010 - v1
Checksum:iAA8C05ADEE629557
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667741 Genomic DNA Translation: CBJ80094.1
RefSeqiWP_012987516.1, NC_013892.1

Genome annotation databases

EnsemblBacteriaiCBJ80094; CBJ80094; XBJ1_0953
GeneIDi8830580
KEGGixbo:XBJ1_0953
PATRICifig|406818.4.peg.866

Similar proteinsi

Entry informationi

Entry nameiCPDA_XENBS
AccessioniPrimary (citable) accession number: D3UX49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health