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D3UX49

- CPDA_XENBS

UniProt

D3UX49 - CPDA_XENBS

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, XBJ1_0953
Organism
Xenorhabdus bovienii (strain SS-2004)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1 By similarity
Metal bindingi10 – 101Metal cation 1 By similarity
Binding sitei10 – 101cAMP By similarity
Metal bindingi52 – 521Metal cation 1 By similarity
Metal bindingi52 – 521Metal cation 2 By similarity
Binding sitei52 – 521cAMP By similarity
Metal bindingi82 – 821Metal cation 2 By similarity
Metal bindingi154 – 1541Metal cation 2 By similarity
Metal bindingi192 – 1921Metal cation 2 By similarity
Metal bindingi194 – 1941Metal cation 1 By similarity
Binding sitei194 – 1941cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 832cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXBOV406818:GHLH-953-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:XBJ1_0953
OrganismiXenorhabdus bovienii (strain SS-2004)
Taxonomic identifieri406818 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus
ProteomesiUP000002045: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2472473',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000413384Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD3UX49.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

D3UX49-1 [UniParc]FASTAAdd to Basket

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MKVVNLTDIH LTRNRDKKLF DVNTYDNFDF VCEEIHRIQN LTEIELIIVS    50
GDIANDGDVE AYRYFLNKME SLKTPYISIL GNHDLNKNFE ITLAEEKPKY 100
IISSREYNND NWYITAVDTV VEGEDYGFIT QDNLAELERK IITNSNFNIA 150
IFMHHHAMPV GTPIVDSCML NNAKAILELC EKHRVKFIGS GHAHTPRVWH 200
HNNMTACVSP AVSFQWLSGT NTVKISKGFG FNVIDFSPDL SITSCIY 247
Length:247
Mass (Da):28,252
Last modified:April 20, 2010 - v1
Checksum:iAA8C05ADEE629557
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN667741 Genomic DNA. Translation: CBJ80094.1.
RefSeqiWP_012987516.1. NC_013892.1.
YP_003466886.1. NC_013892.1.

Genome annotation databases

EnsemblBacteriaiCBJ80094; CBJ80094; XBJ1_0953.
GeneIDi8830580.
KEGGixbo:XBJ1_0953.
PATRICi35296986. VBIXenBov95754_0866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN667741 Genomic DNA. Translation: CBJ80094.1 .
RefSeqi WP_012987516.1. NC_013892.1.
YP_003466886.1. NC_013892.1.

3D structure databases

ProteinModelPortali D3UX49.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBJ80094 ; CBJ80094 ; XBJ1_0953 .
GeneIDi 8830580.
KEGGi xbo:XBJ1_0953.
PATRICi 35296986. VBIXenBov95754_0866.

Enzyme and pathway databases

BioCyci XBOV406818:GHLH-953-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
    Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS-2004.

Entry informationi

Entry nameiCPDA_XENBS
AccessioniPrimary (citable) accession number: D3UX49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3