D3UX49 (CPDA_XENBS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17

Gene names

Name:	cpdA
Ordered Locus Names:	XBJ1_0953

Organism

Xenorhabdus bovienii (strain SS-2004) [Complete proteome] [HAMAP]

Taxonomic identifier

406818 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Xenorhabdus › Xenorhabdus bovienii

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905
Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905
Cofactor	Binds 2 metal cations per subunit By similarity.
Sequence similarities	Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
Ligand	Metal-binding Nucleotide-binding cAMP
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905		PRO_0000413384
Regions
	Nucleotide binding	82 – 83	2	cAMP By similarity
Sites
	Metal binding	8	1	Metal cation 1 By similarity
	Metal binding	10	1	Metal cation 1 By similarity
	Metal binding	52	1	Metal cation 1 By similarity
	Metal binding	52	1	Metal cation 2 By similarity
	Metal binding	82	1	Metal cation 2 By similarity
	Metal binding	154	1	Metal cation 2 By similarity
	Metal binding	192	1	Metal cation 2 By similarity
	Metal binding	194	1	Metal cation 1 By similarity
	Binding site	10	1	cAMP By similarity
	Binding site	52	1	cAMP By similarity
	Binding site	194	1	cAMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	D3UX49 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: AA8C05ADEE629557	FASTA	247	28,252
	10 20 30 40 50 60 MKVVNLTDIH LTRNRDKKLF DVNTYDNFDF VCEEIHRIQN LTEIELIIVS GDIANDGDVE 70 80 90 100 110 120 AYRYFLNKME SLKTPYISIL GNHDLNKNFE ITLAEEKPKY IISSREYNND NWYITAVDTV 130 140 150 160 170 180 VEGEDYGFIT QDNLAELERK IITNSNFNIA IFMHHHAMPV GTPIVDSCML NNAKAILELC 190 200 210 220 230 240 EKHRVKFIGS GHAHTPRVWH HNNMTACVSP AVSFQWLSGT NTVKISKGFG FNVIDFSPDL SITSCIY

References

[1]

"Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)." Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SS-2004.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FN667741 Genomic DNA. Translation: CBJ80094.1.
RefSeq	YP_003466886.1. NC_013892.1.
3D structure databases
ProteinModelPortal	D3UX49.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CBJ80094; CBJ80094; XBJ1_0953.
GeneID	8830580.
KEGG	xbo:XBJ1_0953.
PATRIC	35296986. VBIXenBov95754_0866.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00905. cAMP_phophodiest_CpdA.
InterPro	IPR024654. Calcineurin-like_PEstase_dom. IPR026575. cAMP_Pdiest_CpdA. [Graphical view]
Pfam	PF12850. Metallophos_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CPDA_XENBS

Accession

Primary (citable) accession number: D3UX49

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program