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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Xenorhabdus bovienii (strain SS-2004)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Metal cation 1UniRule annotation1
Metal bindingi10Metal cation 1UniRule annotation1
Binding sitei10cAMPUniRule annotation1
Metal bindingi52Metal cation 1UniRule annotation1
Metal bindingi52Metal cation 2UniRule annotation1
Binding sitei52cAMPUniRule annotation1
Metal bindingi82Metal cation 2UniRule annotation1
Metal bindingi154Metal cation 2UniRule annotation1
Metal bindingi192Metal cation 2UniRule annotation1
Metal bindingi194Metal cation 1UniRule annotation1
Binding sitei194cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 83cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:XBJ1_0953
OrganismiXenorhabdus bovienii (strain SS-2004)
Taxonomic identifieri406818 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeXenorhabdus
Proteomesi
  • UP000002045 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133841 – 2473',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST247

Interactioni

Protein-protein interaction databases

STRINGi406818.XBJ1_0953.

Structurei

3D structure databases

ProteinModelPortaliD3UX49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
OMAiENYGANI.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 2 hits.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

D3UX49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVNLTDIH LTRNRDKKLF DVNTYDNFDF VCEEIHRIQN LTEIELIIVS
60 70 80 90 100
GDIANDGDVE AYRYFLNKME SLKTPYISIL GNHDLNKNFE ITLAEEKPKY
110 120 130 140 150
IISSREYNND NWYITAVDTV VEGEDYGFIT QDNLAELERK IITNSNFNIA
160 170 180 190 200
IFMHHHAMPV GTPIVDSCML NNAKAILELC EKHRVKFIGS GHAHTPRVWH
210 220 230 240
HNNMTACVSP AVSFQWLSGT NTVKISKGFG FNVIDFSPDL SITSCIY
Length:247
Mass (Da):28,252
Last modified:April 20, 2010 - v1
Checksum:iAA8C05ADEE629557
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667741 Genomic DNA. Translation: CBJ80094.1.
RefSeqiWP_012987516.1. NC_013892.1.

Genome annotation databases

EnsemblBacteriaiCBJ80094; CBJ80094; XBJ1_0953.
GeneIDi8830580.
KEGGixbo:XBJ1_0953.
PATRICi35296986. VBIXenBov95754_0866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667741 Genomic DNA. Translation: CBJ80094.1.
RefSeqiWP_012987516.1. NC_013892.1.

3D structure databases

ProteinModelPortaliD3UX49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi406818.XBJ1_0953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBJ80094; CBJ80094; XBJ1_0953.
GeneIDi8830580.
KEGGixbo:XBJ1_0953.
PATRICi35296986. VBIXenBov95754_0866.

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
OMAiENYGANI.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 2 hits.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_XENBS
AccessioniPrimary (citable) accession number: D3UX49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.