Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D3UX49 (CPDA_XENBS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:XBJ1_0953
OrganismXenorhabdus bovienii (strain SS-2004) [Complete proteome] [HAMAP]
Taxonomic identifier406818 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2472473',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413384

Regions

Nucleotide binding82 – 832cAMP By similarity

Sites

Metal binding81Metal cation 1 By similarity
Metal binding101Metal cation 1 By similarity
Metal binding521Metal cation 1 By similarity
Metal binding521Metal cation 2 By similarity
Metal binding821Metal cation 2 By similarity
Metal binding1541Metal cation 2 By similarity
Metal binding1921Metal cation 2 By similarity
Metal binding1941Metal cation 1 By similarity
Binding site101cAMP By similarity
Binding site521cAMP By similarity
Binding site1941cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
D3UX49 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: AA8C05ADEE629557

FASTA24728,252
        10         20         30         40         50         60 
MKVVNLTDIH LTRNRDKKLF DVNTYDNFDF VCEEIHRIQN LTEIELIIVS GDIANDGDVE 

        70         80         90        100        110        120 
AYRYFLNKME SLKTPYISIL GNHDLNKNFE ITLAEEKPKY IISSREYNND NWYITAVDTV 

       130        140        150        160        170        180 
VEGEDYGFIT QDNLAELERK IITNSNFNIA IFMHHHAMPV GTPIVDSCML NNAKAILELC 

       190        200        210        220        230        240 
EKHRVKFIGS GHAHTPRVWH HNNMTACVSP AVSFQWLSGT NTVKISKGFG FNVIDFSPDL 


SITSCIY 

« Hide

References

[1]"Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS-2004.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN667741 Genomic DNA. Translation: CBJ80094.1.
RefSeqYP_003466886.1. NC_013892.1.

3D structure databases

ProteinModelPortalD3UX49.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBJ80094; CBJ80094; XBJ1_0953.
GeneID8830580.
KEGGxbo:XBJ1_0953.
PATRIC35296986. VBIXenBov95754_0866.

Organism-specific databases

CMRSearch...

Enzyme and pathway databases

BioCycXBOV406818:GHLH-953-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPDA_XENBS
AccessionPrimary (citable) accession number: D3UX49
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 20, 2010
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families