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D3UX49

- CPDA_XENBS

UniProt

D3UX49 - CPDA_XENBS

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Xenorhabdus bovienii (strain SS-2004)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Metal cation 1UniRule annotation
    Metal bindingi10 – 101Metal cation 1UniRule annotation
    Binding sitei10 – 101cAMPUniRule annotation
    Metal bindingi52 – 521Metal cation 1UniRule annotation
    Metal bindingi52 – 521Metal cation 2UniRule annotation
    Binding sitei52 – 521cAMPUniRule annotation
    Metal bindingi82 – 821Metal cation 2UniRule annotation
    Metal bindingi154 – 1541Metal cation 2UniRule annotation
    Metal bindingi192 – 1921Metal cation 2UniRule annotation
    Metal bindingi194 – 1941Metal cation 1UniRule annotation
    Binding sitei194 – 1941cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 832cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciXBOV406818:GHLH-953-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:XBJ1_0953
    OrganismiXenorhabdus bovienii (strain SS-2004)
    Taxonomic identifieri406818 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus
    ProteomesiUP000002045: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2472473',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413384Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD3UX49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF12850. Metallophos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3UX49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVVNLTDIH LTRNRDKKLF DVNTYDNFDF VCEEIHRIQN LTEIELIIVS    50
    GDIANDGDVE AYRYFLNKME SLKTPYISIL GNHDLNKNFE ITLAEEKPKY 100
    IISSREYNND NWYITAVDTV VEGEDYGFIT QDNLAELERK IITNSNFNIA 150
    IFMHHHAMPV GTPIVDSCML NNAKAILELC EKHRVKFIGS GHAHTPRVWH 200
    HNNMTACVSP AVSFQWLSGT NTVKISKGFG FNVIDFSPDL SITSCIY 247
    Length:247
    Mass (Da):28,252
    Last modified:April 20, 2010 - v1
    Checksum:iAA8C05ADEE629557
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN667741 Genomic DNA. Translation: CBJ80094.1.
    RefSeqiWP_012987516.1. NC_013892.1.
    YP_003466886.1. NC_013892.1.

    Genome annotation databases

    EnsemblBacteriaiCBJ80094; CBJ80094; XBJ1_0953.
    GeneIDi8830580.
    KEGGixbo:XBJ1_0953.
    PATRICi35296986. VBIXenBov95754_0866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN667741 Genomic DNA. Translation: CBJ80094.1 .
    RefSeqi WP_012987516.1. NC_013892.1.
    YP_003466886.1. NC_013892.1.

    3D structure databases

    ProteinModelPortali D3UX49.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBJ80094 ; CBJ80094 ; XBJ1_0953 .
    GeneIDi 8830580.
    KEGGi xbo:XBJ1_0953.
    PATRICi 35296986. VBIXenBov95754_0866.

    Enzyme and pathway databases

    BioCyci XBOV406818:GHLH-953-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF12850. Metallophos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
      Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS-2004.

    Entry informationi

    Entry nameiCPDA_XENBS
    AccessioniPrimary (citable) accession number: D3UX49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3