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D3UPK5 (D3UPK5_LISSS) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pantothenate synthetase HAMAP-Rule MF_00158
Short name=PS HAMAP-Rule MF_00158
EC=6.3.2.1 HAMAP-Rule MF_00158
Alternative name(s):
Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Pantoate-activating enzyme HAMAP-Rule MF_00158
Gene names
Name:panC HAMAP-Rule MF_00158 EMBL CBH28038.1
Ordered Locus Names:lse_1887
OrganismListeria seeligeri serovar 1/2b (strain ATCC 35967 / DSM 20751 / CIP 100100 / SLCC 3954) [Complete proteome] [HAMAP]
Taxonomic identifier683837 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria ›

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158 SAAS SAAS003721

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158 SAAS SAAS003721

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158 SAAS SAAS003721

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158 SAAS SAAS003721

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158 SAAS SAAS003721.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP-Rule MF_00158

Sequence similarities

Belongs to the pantothenate synthetase family. HAMAP-Rule MF_00158

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding30 – 378ATP By similarity HAMAP-Rule MF_00158
Nucleotide binding147 – 1504ATP By similarity HAMAP-Rule MF_00158
Nucleotide binding184 – 1874ATP By similarity HAMAP-Rule MF_00158

Sites

Active site371Proton donor By similarity HAMAP-Rule MF_00158
Binding site611Beta-alanine By similarity HAMAP-Rule MF_00158
Binding site611Pantoate By similarity HAMAP-Rule MF_00158
Binding site1531Pantoate By similarity HAMAP-Rule MF_00158
Binding site1761ATP; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
D3UPK5 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: C367F6862326E6DD

FASTA28531,991
        10         20         30         40         50         60 
MQIIRNRQTL IDAITEQKKS NKTIGFVPTM GFLHEGHMTL VSHARKENDC VVMSVFVNPT 

        70         80         90        100        110        120 
QFGPNEDFDA YPRDEAHDAK FAEAGGVDIL FIPTVEEMYP AELATKLHVE KRVSVLDGAD 

       130        140        150        160        170        180 
REGHFDGVVT VLTKLFHLVS PDNAYFGQKD AQQVAVVSGL VDDYFFPVNL RVIATVREQD 

       190        200        210        220        230        240 
GLAKSSRNVY LSELERKEAP VIHEALTLGR KLIEAGETNE SKIIQQMTAK INEQTAHEKI 

       250        260        270        280 
AYLAIYSYPE FTPVTDWTKG IIIAAAVKYS KARLIDNELI NVKRR

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References

[1]"Complete genome sequence of Listeria seeligeri, a nonpathogenic member of the genus Listeria."
Steinweg C., Kuenne C.T., Billion A., Mraheil M.A., Domann E., Ghai R., Barbuddhe S.B., Karst U., Goesmann A., Puhler A., Weisshaar B., Wehland J., Lampidis R., Kreft J., Goebel W., Chakraborty T., Hain T.
J. Bacteriol. 192:1473-1474(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35967 / DSM 20751 / CIP 100100 / SLCC 3954.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN557490 Genomic DNA. Translation: CBH28038.1.
RefSeqYP_003465122.1. NC_013891.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBH28038; CBH28038; lse_1887.
GeneID9083391.
KEGGlsg:lse_1887.
PATRIC32263720. VBILisSee138575_1880.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000175517.
KOK01918.

Enzyme and pathway databases

BioCycLSEE683837:GI10-2460-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD3UPK5_LISSS
AccessionPrimary (citable) accession number: D3UPK5
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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