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D3UML3

- D3UML3_LISSS

UniProt

D3UML3 - D3UML3_LISSS

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

gid

Organism
Listeria seeligeri serovar 1/2b (strain ATCC 35967 / DSM 20751 / CIP 100100 / SLCC 3954)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

    Cofactori

    FAD.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    FADUniRule annotationSAAS annotation, Flavoprotein

    Enzyme and pathway databases

    BioCyciLSEE683837:GI10-1218-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:gidImported
    Synonyms:trmFOUniRule annotation
    Ordered Locus Names:lse_1195Imported
    OrganismiListeria seeligeri serovar 1/2b (strain ATCC 35967 / DSM 20751 / CIP 100100 / SLCC 3954)Imported
    Taxonomic identifieri683837 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002044: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3UML3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3UML3-1 [UniParc]FASTAAdd to Basket

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    MEKRVNVIGA GLAGSEATWQ LVKRGIEVDL YEMRPVKQTP AHHTDKFAEL    50
    VCTNSLRANG LTNAVGVIKE EMRILDSIII EAADEASVPA GGALAVDRHE 100
    FSGYITDKVK NHPLVTVHTE EVTTIPTGPT IIATGPLTSP ALAEEIKRLT 150
    GEEYLYFYDA AAPIIEKESI DMNKVYLKSR YDKGEAAYLN CPMSEEEFKA 200
    FYEALVTAET AALKDFEKEV FFEGCMPIEV MAKRGIKTML FGPLKPVGLE 250
    DPKNGKRPYA VLQLRQDDAA GSLYNMVGFQ THLKWGEQKR VFGMIPGLEN 300
    AEIVRYGVMH RNTFINSPTV LEPTYQLKSR NDLFFAGQMT GVEGYVESAA 350
    SGLAAGINAA NFVEEKELII FPKETAIGSL AHYITSASKK SFQPMNVNFG 400
    LFPELASKIR VKQERNEKLA ERALNAIKGV AEGL 434
    Length:434
    Mass (Da):47,849
    Last modified:April 20, 2010 - v1
    Checksum:iA9670A30ACBB0FB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN557490 Genomic DNA. Translation: CBH27346.1.
    RefSeqiYP_003464432.1. NC_013891.1.

    Genome annotation databases

    EnsemblBacteriaiCBH27346; CBH27346; lse_1195.
    GeneIDi9082759.
    KEGGilsg:lse_1195.
    PATRICi32262285. VBILisSee138575_1189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN557490 Genomic DNA. Translation: CBH27346.1 .
    RefSeqi YP_003464432.1. NC_013891.1.

    3D structure databases

    ProteinModelPortali D3UML3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBH27346 ; CBH27346 ; lse_1195 .
    GeneIDi 9082759.
    KEGGi lsg:lse_1195.
    PATRICi 32262285. VBILisSee138575_1189.

    Phylogenomic databases

    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.

    Enzyme and pathway databases

    BioCyci LSEE683837:GI10-1218-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35967 / DSM 20751 / CIP 100100 / SLCC 3954Imported.

    Entry informationi

    Entry nameiD3UML3_LISSS
    AccessioniPrimary (citable) accession number: D3UML3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3