ID   D3UJ25_HELM1            Unreviewed;       586 AA.
AC   D3UJ25;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Putative penicillin-binding protein {ECO:0000313|EMBL:CBG40500.1};
GN   Name=pbpB {ECO:0000313|EMBL:CBG40500.1};
GN   OrderedLocusNames=HMU12460 {ECO:0000313|EMBL:CBG40500.1};
OS   Helicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198)
OS   (Campylobacter mustelae).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=679897 {ECO:0000313|EMBL:CBG40500.1, ECO:0000313|Proteomes:UP000001522};
RN   [1] {ECO:0000313|EMBL:CBG40500.1, ECO:0000313|Proteomes:UP000001522}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43772 / LMG 18044 / NCTC 12198 / 12198
RC   {ECO:0000313|Proteomes:UP000001522};
RX   PubMed=20219135; DOI=10.1186/1471-2164-11-164;
RA   O'Toole P.W., Snelling W.J., Canchaya C., Forde B.M., Hardie K.R.,
RA   Josenhans C., Graham R.L.J., McMullan G., Parkhill J., Belda E.,
RA   Bentley S.D.;
RT   "Comparative genomics and proteomics of Helicobacter mustelae, an
RT   ulcerogenic and carcinogenic gastric pathogen.";
RL   BMC Genomics 11:164-164(2010).
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DR   EMBL; FN555004; CBG40500.1; -; Genomic_DNA.
DR   RefSeq; WP_013023568.1; NC_013949.1.
DR   AlphaFoldDB; D3UJ25; -.
DR   STRING; 679897.HMU12460; -.
DR   KEGG; hms:HMU12460; -.
DR   eggNOG; COG0768; Bacteria.
DR   HOGENOM; CLU_009289_6_4_7; -.
DR   Proteomes; UP000001522; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001522};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          49..226
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          268..573
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   586 AA;  65523 MW;  2096E79859BB7D80 CRC64;
     MNEQSGRIVK VFSVFVVFII IALLLCLFTL GKILGPNHIP FWQSKRIQVA TRGSIYSDDN
     FDLASSQVLY KVSINTLSID PDKRELFINL FSIYSGMSRE ELQAKLKQKG YIVFSYNIPA
     NVAANLRQLR SKLLAYDVFR EYQDSSGRIV QKMGIDVEVS GINRNYAYND ALEPVLGYVK
     KREARSVTIP EGVKGLEKYY NKELSPKQNG IERGDRDIRG NIIRNKTTIL RERINGSDIA
     LHVNLGLQRK VEKMLDEFYQ QYQVDEIVAG VMDPKSGAIF ALATTNRFDP KNITSNHALN
     ASVTERPFEP GSTIKPIVFS ILLDKNLINP LELIDLNKGF LQLGRYTIKD DIYPKKNSIV
     QDILIRSSNV GMIKISRKLS GKEFYEGLKS FGISEASGID LPYERDGVIP SIRKLSGEAY
     KASASYGYGL TTTFIQLLRA YGVFCNNGIL VTPHLIKNIT DPDGKITTPT FPTRQAIAAP
     TARKIQEILI KTVQEGTGKR AKIDNLIVGG KTGTARIAKS GGGYSDNIYN GSFFGFVKGG
     NQTYVIGVVV FGTQHKEDYY GSQTAAPIFK EIARIMQKQN FFKEQK
//