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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Helicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198) (Campylobacter mustelae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421SubstrateUniRule annotation
Sitei252 – 2521Critical for catalysisUniRule annotation
Metal bindingi345 – 3451Magnesium or manganeseUniRule annotation
Sitei415 – 4151Critical for catalysisUniRule annotation
Binding sitei547 – 5471SubstrateUniRule annotation
Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciHMUS679897:GJBK-426-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:HMU04060Imported
OrganismiHelicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198) (Campylobacter mustelae)Imported
Taxonomic identifieri679897 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000001522 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi679897.HMU04060.

Structurei

3D structure databases

ProteinModelPortaliD3UGP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1368Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D3UGP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITYTLTDE SPALATYSFL PIVRAFLHTA GIEVESADIS LAGRILAQFP
60 70 80 90 100
QHLTPSQRIP NALEALGELV KHKDANLIKT PNISASIPQL KNAIAELQAK
110 120 130 140 150
GYNVPNYPDN PKNQEEEEIK ENYQKILGSA VNPVLRQGNS DRRSTKAVKQ
160 170 180 190 200
YAKKNPYKIA PFDSNSKTIV SYMQEGDFFS NEKAVWIKEP TEARIVFENK
210 220 230 240 250
EGKREILKKG LKLEKEEILD ATFMDVEALD RFYVDQIALC KKQDILFSLH
260 270 280 290 300
LKATMMKVSD PVIFGHAVRT FFAELFEEFA DELHALGVNP NNGISELLQK
310 320 330 340 350
IQTSAKKDAI LQKYEEILHK SAKISMVNSD KGITNLHVPS DVIVDASMPA
360 370 380 390 400
MLKNGAKLWD KEGRECDTNA VIPDRTYATI YEAVIEDLHK FGPLDPSKLG
410 420 430 440 450
SVANVGLMAK KAQEYGSHDK TFIAKEAGSF KILDHQDRVL LEHAVQKGDI
460 470 480 490 500
YRANQAKHDA IINWIDLGIQ RSETSHTPAI FWLDEKRPSN KIMIEMVQKR
510 520 530 540 550
LQERGIALKS SHGANLEILP PKAACLKSLE IIRNGGDVIS ITGNVLRDYL
560 570 580 590 600
TDLFPILELG TSAKMLSIVP MLSGGAMFET GAGGSAPKQV EQLLLENHLR
610 620 630 640 650
WDSLGEFLAL QASLEFFAQQ NHNARAKVLA DALDVAIGKW LDNNKAPSRN
660 670 680 690 700
AGQDDNRTSH FYLAMYFAEA LAKQKEDTAL QERFAPIASE LQAKEQKIKE
710 720 730 740
EFLSKEGVSV DLGGYYKFDD EKAIKIMRPS ATFNEILHKI AQ
Length:742
Mass (Da):82,856
Last modified:April 20, 2010 - v1
Checksum:iDAF8E1C16F4A3276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN555004 Genomic DNA. Translation: CBG39668.1.
RefSeqiWP_013022759.1. NC_013949.1.

Genome annotation databases

EnsemblBacteriaiCBG39668; CBG39668; HMU04060.
KEGGihms:HMU04060.
PATRICi35378142. VBIHelMus149082_0479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN555004 Genomic DNA. Translation: CBG39668.1.
RefSeqiWP_013022759.1. NC_013949.1.

3D structure databases

ProteinModelPortaliD3UGP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi679897.HMU04060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBG39668; CBG39668; HMU04060.
KEGGihms:HMU04060.
PATRICi35378142. VBIHelMus149082_0479.

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Enzyme and pathway databases

BioCyciHMUS679897:GJBK-426-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen."
    O'Toole P.W., Snelling W.J., Canchaya C., Forde B.M., Hardie K.R., Josenhans C., Graham R.L., McMullan G., Parkhill J., Belda E., Bentley S.D.
    BMC Genomics 11:164-164(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43772 / LMG 18044 / NCTC 12198 / 12198Imported.

Entry informationi

Entry nameiD3UGP7_HELM1
AccessioniPrimary (citable) accession number: D3UGP7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.