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D3UGP7

- D3UGP7_HELM1

UniProt

D3UGP7 - D3UGP7_HELM1

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Helicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198) (Campylobacter mustelae)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei142 – 1421SubstrateUniRule annotation
    Sitei252 – 2521Critical for catalysisUniRule annotation
    Metal bindingi345 – 3451Magnesium or manganeseUniRule annotation
    Sitei415 – 4151Critical for catalysisUniRule annotation
    Binding sitei547 – 5471SubstrateUniRule annotation
    Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
    Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciHMUS679897:GJBK-426-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:HMU04060Imported
    OrganismiHelicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198) (Campylobacter mustelae)Imported
    Taxonomic identifieri679897 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000001522: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD3UGP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1368Substrate bindingUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3UGP7-1 [UniParc]FASTAAdd to Basket

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    MKITYTLTDE SPALATYSFL PIVRAFLHTA GIEVESADIS LAGRILAQFP    50
    QHLTPSQRIP NALEALGELV KHKDANLIKT PNISASIPQL KNAIAELQAK 100
    GYNVPNYPDN PKNQEEEEIK ENYQKILGSA VNPVLRQGNS DRRSTKAVKQ 150
    YAKKNPYKIA PFDSNSKTIV SYMQEGDFFS NEKAVWIKEP TEARIVFENK 200
    EGKREILKKG LKLEKEEILD ATFMDVEALD RFYVDQIALC KKQDILFSLH 250
    LKATMMKVSD PVIFGHAVRT FFAELFEEFA DELHALGVNP NNGISELLQK 300
    IQTSAKKDAI LQKYEEILHK SAKISMVNSD KGITNLHVPS DVIVDASMPA 350
    MLKNGAKLWD KEGRECDTNA VIPDRTYATI YEAVIEDLHK FGPLDPSKLG 400
    SVANVGLMAK KAQEYGSHDK TFIAKEAGSF KILDHQDRVL LEHAVQKGDI 450
    YRANQAKHDA IINWIDLGIQ RSETSHTPAI FWLDEKRPSN KIMIEMVQKR 500
    LQERGIALKS SHGANLEILP PKAACLKSLE IIRNGGDVIS ITGNVLRDYL 550
    TDLFPILELG TSAKMLSIVP MLSGGAMFET GAGGSAPKQV EQLLLENHLR 600
    WDSLGEFLAL QASLEFFAQQ NHNARAKVLA DALDVAIGKW LDNNKAPSRN 650
    AGQDDNRTSH FYLAMYFAEA LAKQKEDTAL QERFAPIASE LQAKEQKIKE 700
    EFLSKEGVSV DLGGYYKFDD EKAIKIMRPS ATFNEILHKI AQ 742
    Length:742
    Mass (Da):82,856
    Last modified:April 20, 2010 - v1
    Checksum:iDAF8E1C16F4A3276
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN555004 Genomic DNA. Translation: CBG39668.1.
    RefSeqiWP_013022759.1. NC_013949.1.
    YP_003516410.1. NC_013949.1.

    Genome annotation databases

    EnsemblBacteriaiCBG39668; CBG39668; HMU04060.
    GeneIDi8866251.
    KEGGihms:HMU04060.
    PATRICi35378142. VBIHelMus149082_0479.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN555004 Genomic DNA. Translation: CBG39668.1 .
    RefSeqi WP_013022759.1. NC_013949.1.
    YP_003516410.1. NC_013949.1.

    3D structure databases

    ProteinModelPortali D3UGP7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBG39668 ; CBG39668 ; HMU04060 .
    GeneIDi 8866251.
    KEGGi hms:HMU04060.
    PATRICi 35378142. VBIHelMus149082_0479.

    Phylogenomic databases

    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.

    Enzyme and pathway databases

    BioCyci HMUS679897:GJBK-426-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen."
      O'Toole P.W., Snelling W.J., Canchaya C., Forde B.M., Hardie K.R., Josenhans C., Graham R.L.J., McMullan G., Parkhill J., Belda E., Bentley S.D.
      BMC Genomics 11:164-164(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43772 / LMG 18044 / NCTC 12198 / 12198Imported.

    Entry informationi

    Entry nameiD3UGP7_HELM1
    AccessioniPrimary (citable) accession number: D3UGP7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3