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D3UGP7

- D3UGP7_HELM1

UniProt

D3UGP7 - D3UGP7_HELM1

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene
icd, HMU04060
Organism
Helicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198) (Campylobacter mustelae)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421Substrate By similarityUniRule annotation
Sitei252 – 2521Critical for catalysis By similarityUniRule annotation
Metal bindingi345 – 3451Magnesium or manganese By similarity
Sitei415 – 4151Critical for catalysis By similarityUniRule annotation
Binding sitei547 – 5471Substrate By similarityUniRule annotation
Metal bindingi548 – 5481Magnesium or manganese By similarity
Metal bindingi552 – 5521Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciHMUS679897:GJBK-426-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:HMU04060Imported
OrganismiHelicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198) (Campylobacter mustelae)Imported
Taxonomic identifieri679897 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000001522: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD3UGP7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1368Substrate binding By similarityUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D3UGP7-1 [UniParc]FASTAAdd to Basket

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MKITYTLTDE SPALATYSFL PIVRAFLHTA GIEVESADIS LAGRILAQFP    50
QHLTPSQRIP NALEALGELV KHKDANLIKT PNISASIPQL KNAIAELQAK 100
GYNVPNYPDN PKNQEEEEIK ENYQKILGSA VNPVLRQGNS DRRSTKAVKQ 150
YAKKNPYKIA PFDSNSKTIV SYMQEGDFFS NEKAVWIKEP TEARIVFENK 200
EGKREILKKG LKLEKEEILD ATFMDVEALD RFYVDQIALC KKQDILFSLH 250
LKATMMKVSD PVIFGHAVRT FFAELFEEFA DELHALGVNP NNGISELLQK 300
IQTSAKKDAI LQKYEEILHK SAKISMVNSD KGITNLHVPS DVIVDASMPA 350
MLKNGAKLWD KEGRECDTNA VIPDRTYATI YEAVIEDLHK FGPLDPSKLG 400
SVANVGLMAK KAQEYGSHDK TFIAKEAGSF KILDHQDRVL LEHAVQKGDI 450
YRANQAKHDA IINWIDLGIQ RSETSHTPAI FWLDEKRPSN KIMIEMVQKR 500
LQERGIALKS SHGANLEILP PKAACLKSLE IIRNGGDVIS ITGNVLRDYL 550
TDLFPILELG TSAKMLSIVP MLSGGAMFET GAGGSAPKQV EQLLLENHLR 600
WDSLGEFLAL QASLEFFAQQ NHNARAKVLA DALDVAIGKW LDNNKAPSRN 650
AGQDDNRTSH FYLAMYFAEA LAKQKEDTAL QERFAPIASE LQAKEQKIKE 700
EFLSKEGVSV DLGGYYKFDD EKAIKIMRPS ATFNEILHKI AQ 742
Length:742
Mass (Da):82,856
Last modified:April 20, 2010 - v1
Checksum:iDAF8E1C16F4A3276
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN555004 Genomic DNA. Translation: CBG39668.1.
RefSeqiWP_013022759.1. NC_013949.1.
YP_003516410.1. NC_013949.1.

Genome annotation databases

EnsemblBacteriaiCBG39668; CBG39668; HMU04060.
GeneIDi8866251.
KEGGihms:HMU04060.
PATRICi35378142. VBIHelMus149082_0479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN555004 Genomic DNA. Translation: CBG39668.1 .
RefSeqi WP_013022759.1. NC_013949.1.
YP_003516410.1. NC_013949.1.

3D structure databases

ProteinModelPortali D3UGP7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBG39668 ; CBG39668 ; HMU04060 .
GeneIDi 8866251.
KEGGi hms:HMU04060.
PATRICi 35378142. VBIHelMus149082_0479.

Phylogenomic databases

HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.

Enzyme and pathway databases

BioCyci HMUS679897:GJBK-426-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen."
    O'Toole P.W., Snelling W.J., Canchaya C., Forde B.M., Hardie K.R., Josenhans C., Graham R.L.J., McMullan G., Parkhill J., Belda E., Bentley S.D.
    BMC Genomics 11:164-164(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43772 / LMG 18044 / NCTC 12198 / 12198.

Entry informationi

Entry nameiD3UGP7_HELM1
AccessioniPrimary (citable) accession number: D3UGP7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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