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Protein
Submitted name:

Retinoic acid inducible protein I

Gene

RIG-I

Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei706 – 7061ADPCombined sources
Binding sitei733 – 7331ADPCombined sources
Metal bindingi812 – 8121ZincCombined sources
Metal bindingi815 – 8151ZincCombined sources
Metal bindingi866 – 8661ZincCombined sources
Metal bindingi871 – 8711ZincCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi245 – 2506ADPCombined sources
Nucleotide bindingi270 – 2745ADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-bindingCombined sources, Nucleotide-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Retinoic acid inducible protein IImported
Submitted name:
Retinoic acid inducible protein I transcript variant 1Imported
Submitted name:
Retinoic acid inducible protein I transcript variant 2Imported
Gene namesi
Name:RIG-IImported
OrganismiAnas platyrhynchos (Mallard) (Anas boschas)Imported
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnas

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: CACAO
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A2PX-ray3.00A242-794[»]
4A2QX-ray3.40A/B/D/E1-794[»]
4A2VX-ray1.44A806-933[»]
4A2WX-ray3.70A/B2-933[»]
4A2XX-ray4.00A/B/C/D806-933[»]
4A36X-ray3.70A/B242-794[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini254 – 432179Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini611 – 792182Helicase C-terminalInterPro annotationAdd
BLAST

Phylogenomic databases

KOiK12646.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031964. CARD_dom.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF16739. CARD_2. 2 hits.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3TI84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTADEKRSLQ CYRRYIERSL NPVYVLGNMT DWLPDELRER IRKEEERGVS
60 70 80 90 100
GAAALFLDAV LQLEARGWFR GMLDAMLAAG YTGLAEAIEN WDFSKLEKLE
110 120 130 140 150
LHRQLLKRIE ATMLEVDPVA LIPYISTCLI DRECEEIQQI SENRSKAAGI
160 170 180 190 200
TKLIECLCRS DKEHWPKSLQ LALDTTGYYR ASELWDIRED NAKDVDSEMT
210 220 230 240 250
DASEDCLEAS MTYSEEAEPD DNLSENLGSA AEGIGKPPPV YETKKARSYQ
260 270 280 290 300
IELAQPAING KNALICAPTG SGKTFVSILI CEHHFQNMPA GRKAKVVFLA
310 320 330 340 350
TKVPVYEQQK NVFKHHFERQ GYSVQGISGE NFSNVSVEKV IEDSDIIVVT
360 370 380 390 400
PQILVNSFED GTLTSLSIFT LMIFDECHNT TGNHPYNVLM TRYLEQKFNS
410 420 430 440 450
ASQLPQILGL TASVGVGNAK NIEETIEHIC SLCSYLDIQA ISTVRENIQE
460 470 480 490 500
LQRFMNKPEI DVRLVKRRIH NPFAAIISNL MSETEALMRT IYSVDTLSQN
510 520 530 540 550
SKKDFGTQNY EHWIVVTQRK CRLLQLEDKE EESRICRALF ICTEHLRKYN
560 570 580 590 600
DALIISEDAR IIDALSYLTE FFTNVKNGPY TELEQHLTAK FQEKEPELIA
610 620 630 640 650
LSKDETNENP KLEELVCILD DAYRYNPQTR TLLFAKTRAL VSALKKCMEE
660 670 680 690 700
NPILNYIKPG VLMGRGRRDQ TTGMTLPSQK GVLDAFKTSK DNRLLIATSV
710 720 730 740 750
ADEGIDIVQC NLVVLYEYSG NVTKMIQVRG RGRAAGSKCI LVTSKTEVVE
760 770 780 790 800
NEKCNRYKEE MMNKAVEKIQ KWDEETFAKK IHNLQMKERV LRDSRRKEIK
810 820 830 840 850
PKVVEGQKNL LCGKCKAYAC STDDIRIIKD SHHIVLGEAF KERYTTKPHK
860 870 880 890 900
KPMQFDGFEK KSKMYCRNNN CQHDWGITVK YLTFDNLPVI KIKSFVMEST
910 920 930
ATGTQMDFQK WKSINSSLKN FDVEEMSNLY PPF
Length:933
Mass (Da):106,605
Last modified:April 20, 2010 - v1
Checksum:i642BE7324C693EA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU363349 mRNA. Translation: ACA61272.1.
JQ946323 mRNA. Translation: AFK82315.1.
KC869660 mRNA. Translation: AGS16703.1.
RefSeqiNP_001297309.1. NM_001310380.1.

Genome annotation databases

GeneIDi101789567.
KEGGiapla:101789567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU363349 mRNA. Translation: ACA61272.1.
JQ946323 mRNA. Translation: AFK82315.1.
KC869660 mRNA. Translation: AGS16703.1.
RefSeqiNP_001297309.1. NM_001310380.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A2PX-ray3.00A242-794[»]
4A2QX-ray3.40A/B/D/E1-794[»]
4A2VX-ray1.44A806-933[»]
4A2WX-ray3.70A/B2-933[»]
4A2XX-ray4.00A/B/C/D806-933[»]
4A36X-ray3.70A/B242-794[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101789567.
KEGGiapla:101789567.

Organism-specific databases

CTDi23586.

Phylogenomic databases

KOiK12646.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031964. CARD_dom.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF16739. CARD_2. 2 hits.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA."
    Kowalinski E., Lunardi T., McCarthy A.A., Louber J., Brunel J., Grigorov B., Gerlier D., Cusack S.
    Cell 147:423-435(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 806-933 IN COMPLEX WITH ADP AND ZINC.
  4. "Molecular characterization, expression patterns, and subcellular localization of RIG-I in the Jinding duck (Anas platyrhynchos domesticus)."
    Chen Y., Zhang Y., Huang Z., Xu Q., Zhu Z., Tong Y., Yu Q., Ding J., Chen G.
    Dev. Comp. Immunol. 41:766-771(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD3TI84_ANAPL
AccessioniPrimary (citable) accession number: D3TI84
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 6, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.