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D3SZI3

- D3SZI3_NATMM

UniProt

D3SZI3 - D3SZI3_NATMM

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, Nmag_0732, C500_16200
Organism
Natrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) (Natronobacterium magadii)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptor By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Metal bindingi178 – 1781Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi180 – 1801Magnesium By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Active sitei270 – 2701Proton acceptor By similarityUniRule annotation
Binding sitei271 – 2711Substrate By similarityUniRule annotation
Binding sitei303 – 3031Substrate By similarityUniRule annotation
Sitei311 – 3111Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciNMAG547559:GJAP-746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotationImported
Ordered Locus Names:Nmag_0732Imported
ORF Names:C500_16200Imported
OrganismiNatrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) (Natronobacterium magadii)Imported
Taxonomic identifieri547559 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatrialba
ProteomesiUP000001879: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni339 – 3413Substrate binding By similarityUniRule annotation
Regioni361 – 3644Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

D3SZI3-1 [UniParc]FASTAAdd to Basket

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MTGIEYDDFL DREYNPDSTD LVCTFRIDPA EDMSMEAAAS RVASESSNGT    50
WAALHVDEDE LTHLGAVAYG IDGDEITVAY PAELFEAGSM PQILSCIAGN 100
IMGMKAVDAI RLEDCKWPES ITSGFPGPQF GTSVAREKLD AGDRPILATV 150
PKPKVGLSTD AHVRVGEEAW RGGVDLLKDD ENLTDQDFNP FEDRLAESLA 200
ARDRVEEDVG ERKDYLVNVT AETNEMLERV DLVDEHGGGF VMVDIITCGW 250
SAVQSVRDRC EKHGLAIHAH RAMHAAFDRM DHHGVSMRVI AQISRLCGVD 300
HIHTGTAGLG KLANEDTPGI NDWLHGNCHG LNPVLPVASG GLHPGVVDQL 350
IDALGTDICV QAGGGIHGHP DGTHAGAKAL RQATDASLDG VPLEEYAQDP 400
AHAELATALK KWGAETPR 418
Length:418
Mass (Da):44,905
Last modified:April 20, 2010 - v1
Checksum:iC582979A06488EA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001932 Genomic DNA. Translation: ADD04317.1.
AOHS01000051 Genomic DNA. Translation: ELY26719.1.
RefSeqiYP_003478879.1. NC_013922.1.

Genome annotation databases

EnsemblBacteriaiADD04317; ADD04317; Nmag_0732.
ELY26719; ELY26719; C500_16200.
GeneIDi8823560.
KEGGinmg:Nmag_0732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001932 Genomic DNA. Translation: ADD04317.1 .
AOHS01000051 Genomic DNA. Translation: ELY26719.1 .
RefSeqi YP_003478879.1. NC_013922.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD04317 ; ADD04317 ; Nmag_0732 .
ELY26719 ; ELY26719 ; C500_16200 .
GeneIDi 8823560.
KEGGi nmg:Nmag_0732.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci NMAG547559:GJAP-746-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Natrialba magadii ATCC 43099."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E., Maupin-Furlow J.A., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3.
  2. "A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T."
    Siddaramappa S., Challacombe J.F., Decastro R.E., Pfeiffer F., Sastre D.E., Gimenez M.I., Paggi R.A., Detter J.C., Davenport K.W., Goodwin L.A., Kyrpides N., Tapia R., Pitluck S., Lucas S., Woyke T., Maupin-Furlow J.A.
    BMC Genomics 13:165-165(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 43099Imported.
  3. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MS-3Imported.

Entry informationi

Entry nameiD3SZI3_NATMM
AccessioniPrimary (citable) accession number: D3SZI3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi