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D3SYT3

- D3SYT3_NATMM

UniProt

D3SYT3 - D3SYT3_NATMM

Protein

DNA ligase

Gene

lig

Organism
Natrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) (Natronobacterium magadii)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei292 – 2921ATPUniRule annotation
    Active sitei294 – 2941N6-AMP-lysine intermediateUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei325 – 3251ATPUniRule annotation
    Binding sitei354 – 3541ATPUniRule annotation
    Binding sitei394 – 3941ATPUniRule annotation
    Binding sitei475 – 4751ATPUniRule annotation
    Binding sitei481 – 4811ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNMAG547559:GJAP-621-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Nmag_0608Imported
    ORF Names:C500_15590Imported
    OrganismiNatrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) (Natronobacterium magadii)Imported
    Taxonomic identifieri547559 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatrialba
    ProteomesiUP000001879: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 2 hits.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 2 hits.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3SYT3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFATFADRA ATIEAESADL EIVAHVRDLL AEAGDDLPIV ARFVQGRVFP    50
    AWDSTTLDIG PNTCYEAIAR AAGTNVDADD VEERLADRGE IGAVAASYDF 100
    GGQQGLGAFM SGGGSGAGGA VDNNDDQDDR NNGGNGSNSG NDSNSSNDSN 150
    SSNGTGDLTV REINDTLTDL AAAEGSGSQD RKVDLLFGLF NRCSSDEARY 200
    LARLVLSEMR IGVGEGTVRD AIAEAFEVPQ EPVERALQVS NDYGQVAETA 250
    REDGVDGLDE IDLEIGRPVQ AMLAQAGTVT DALEEWDEAA VEWKYDGARI 300
    QLHYDPAGPG GPDGDSNGET HVFSRNMEAV TDALPEVVEF ADEHLDGPAI 350
    LDGEVVAIDD DGNPLPFQEV LKRFRRKHDV AKARENVSVR PVFFDCLHAD 400
    GDDLLEEPLV ERHNQLESVL AMGPQQEPEE IDGFSLLWVT DNPDEIEAVD 450
    ADALEAGHEG IMLKNPDSAY SPGRRGKNWQ KRKPDVETLD CVVTGAEWGE 500
    GRRATFLGTF ELSVRDGDDL ETVGKVATGI TDEKLEELTE LLEPHIVAED 550
    GTAVELEPAV VFEVGYEEIQ TSPTYSSGYA LRFPRFLGVR YDKDTAGAET 600
    LERLETLFES 610
    Length:610
    Mass (Da):65,823
    Last modified:April 20, 2010 - v1
    Checksum:iAAB053AF4CC701D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001932 Genomic DNA. Translation: ADD04194.1.
    AOHS01000051 Genomic DNA. Translation: ELY26599.1.
    RefSeqiYP_003478756.1. NC_013922.1.

    Genome annotation databases

    EnsemblBacteriaiADD04194; ADD04194; Nmag_0608.
    ELY26599; ELY26599; C500_15590.
    GeneIDi8823435.
    KEGGinmg:Nmag_0608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001932 Genomic DNA. Translation: ADD04194.1 .
    AOHS01000051 Genomic DNA. Translation: ELY26599.1 .
    RefSeqi YP_003478756.1. NC_013922.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADD04194 ; ADD04194 ; Nmag_0608 .
    ELY26599 ; ELY26599 ; C500_15590 .
    GeneIDi 8823435.
    KEGGi nmg:Nmag_0608.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci NMAG547559:GJAP-621-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 2 hits.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 2 hits.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Natrialba magadii ATCC 43099."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E., Maupin-Furlow J.A., Woyke T.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3Imported.
    2. "A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T."
      Siddaramappa S., Challacombe J.F., Decastro R.E., Pfeiffer F., Sastre D.E., Gimenez M.I., Paggi R.A., Detter J.C., Davenport K.W., Goodwin L.A., Kyrpides N., Tapia R., Pitluck S., Lucas S., Woyke T., Maupin-Furlow J.A.
      BMC Genomics 13:165-165(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 43099Imported.
    3. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
      Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MS-3Imported.

    Entry informationi

    Entry nameiD3SYT3_NATMM
    AccessioniPrimary (citable) accession number: D3SYT3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3