Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA ligase

Gene

ligB

Organism
Natrialba magadii (strain ATCC 43099 / DSM 3394 / CIP 104546 / JCM 8861/ NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium magadii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei292ATPUniRule annotation1
Active sitei294N6-AMP-lysine intermediateUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei325ATPUniRule annotation1
Binding sitei354ATPUniRule annotation1
Binding sitei394ATPUniRule annotation1
Binding sitei475ATPUniRule annotation1
Binding sitei481ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMAG547559:G1GHK-588-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:Nmag_0608Imported
ORF Names:C500_15590Imported
OrganismiNatrialba magadii (strain ATCC 43099 / DSM 3394 / CIP 104546 / JCM 8861/ NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium magadii)Imported
Taxonomic identifieri547559 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaNatrialbalesNatrialbaceaeNatrialba
Proteomesi
  • UP000011543 Componenti: Unassembled WGS sequence
  • UP000001879 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi547559.Nmag_0608

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini382 – 516DNA_LIGASE_A3InterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 2 hits
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 2 hits
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

D3SYT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFATFADRA ATIEAESADL EIVAHVRDLL AEAGDDLPIV ARFVQGRVFP
60 70 80 90 100
AWDSTTLDIG PNTCYEAIAR AAGTNVDADD VEERLADRGE IGAVAASYDF
110 120 130 140 150
GGQQGLGAFM SGGGSGAGGA VDNNDDQDDR NNGGNGSNSG NDSNSSNDSN
160 170 180 190 200
SSNGTGDLTV REINDTLTDL AAAEGSGSQD RKVDLLFGLF NRCSSDEARY
210 220 230 240 250
LARLVLSEMR IGVGEGTVRD AIAEAFEVPQ EPVERALQVS NDYGQVAETA
260 270 280 290 300
REDGVDGLDE IDLEIGRPVQ AMLAQAGTVT DALEEWDEAA VEWKYDGARI
310 320 330 340 350
QLHYDPAGPG GPDGDSNGET HVFSRNMEAV TDALPEVVEF ADEHLDGPAI
360 370 380 390 400
LDGEVVAIDD DGNPLPFQEV LKRFRRKHDV AKARENVSVR PVFFDCLHAD
410 420 430 440 450
GDDLLEEPLV ERHNQLESVL AMGPQQEPEE IDGFSLLWVT DNPDEIEAVD
460 470 480 490 500
ADALEAGHEG IMLKNPDSAY SPGRRGKNWQ KRKPDVETLD CVVTGAEWGE
510 520 530 540 550
GRRATFLGTF ELSVRDGDDL ETVGKVATGI TDEKLEELTE LLEPHIVAED
560 570 580 590 600
GTAVELEPAV VFEVGYEEIQ TSPTYSSGYA LRFPRFLGVR YDKDTAGAET
610
LERLETLFES
Length:610
Mass (Da):65,823
Last modified:April 20, 2010 - v1
Checksum:iAAB053AF4CC701D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001932 Genomic DNA Translation: ADD04194.1
AOHS01000051 Genomic DNA Translation: ELY26599.1
RefSeqiWP_004216345.1, NZ_AOHS01000051.1

Genome annotation databases

EnsemblBacteriaiADD04194; ADD04194; Nmag_0608
ELY26599; ELY26599; C500_15590
GeneIDi8823435
KEGGinmg:Nmag_0608
PATRICifig|547559.17.peg.3058

Similar proteinsi

Entry informationi

Entry nameiD3SYT3_NATMM
AccessioniPrimary (citable) accession number: D3SYT3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health