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D3SX76 (D3SX76_NATMM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length846 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1301O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
D3SX76 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 74AB9EEC56DFF871

FASTA84693,572
        10         20         30         40         50         60 
MSSDVPDPTD VEARAVENVR IEDEMEQSYI DYAMSVIAGR ALPDVRDGLK PVHRRILYAM 

        70         80         90        100        110        120 
HEMGVTSRSS HRKSSSIVGE TMGDYHPHGD SAIYDTLVRM AQDFSMRYPL VDGQGNFGSM 

       130        140        150        160        170        180 
DGDPAAAPRY TEARMAAVSE ELLEDIDKDT VDFSSNYDDR LQEPDVLPSA FPNLLVNGSS 

       190        200        210        220        230        240 
GIAVGMSTNI PPHNLGEVID ATIELIDDPD ATVEDLMEHV KGPDFPTGAN IVGRDAIYSA 

       250        260        270        280        290        300 
YKTGRGRIRV RAEFEVEEWK NGRERIVITE LPYQENKARL VERIAEDVNE GDIEGISDLR 

       310        320        330        340        350        360 
DESDRDGVRI VVECKRGANV EVVKNKLLEN HLEKTFGVIN LALVDGQPQV LSLKETLEEY 

       370        380        390        400        410        420 
IAHRREVVRR RSEYDLAEAE DRAHILEGRL KAVENAEDVV DLIRNSETRD DAKAALQEAY 

       430        440        450        460        470        480 
DFSAEQATHI VRMQLGSLTS MEAAEIEDEY EDVQAEIERL TSILESEQEL LAVIKDELSE 

       490        500        510        520        530        540 
IKDEYDDDRR TSIIEDQGTV THEDLIPEEE VFVVMTEDDY VKRMPISQFD PQGRGGKGII 

       550        560        570        580        590        600 
GADVKEDDRV ATVFRANTHD YLLCFTNQGK VYQLKTYEIP EMGRTARGKS AVNILDLDPG 

       610        620        630        640        650        660 
EDITAIVDTD AFGDDEFVTM ATRHGYVKRT AGSEFDNIRS TGIIAADLQE GDELVDVEVT 

       670        680        690        700        710        720 
DGTKDLVIAS ENGMTIRFDE DEVRAMGRNA RGVNGIDLQG DDAVAGLVAT DEGDEQDLLT 

       730        740        750        760        770        780 
VTQNGYGKRT PLSEYRTQSR YGKGLIDIKT GERNGPVTTA KAVSADDQLV MMSERGQIVR 

       790        800        810        820        830        840 
TRVDEISTVG RNTMGVIVMD VDDGDAVASV DVVPAAVSEA DDDGEDEDED EGQNEDTETV 


EADAAN

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References

[1]"Complete sequence of chromosome of Natrialba magadii ATCC 43099."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E., Maupin-Furlow J.A., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001932 Genomic DNA. Translation: ADD03896.1.
RefSeqYP_003478458.1. NC_013922.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADD03896; ADD03896; Nmag_0305.
GeneID8823126.
KEGGnmg:Nmag_0305.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.

Enzyme and pathway databases

BioCycNMAG547559:GJAP-312-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD3SX76_NATMM
AccessionPrimary (citable) accession number: D3SX76
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info