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D3SUN8 (D3SUN8_NATMM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uracil phosphoribosyltransferase HAMAP-Rule MF_01218
EC=2.4.2.9 HAMAP-Rule MF_01218
Alternative name(s):
UMP pyrophosphorylase HAMAP-Rule MF_01218
UPRTase HAMAP-Rule MF_01218
Gene names
Name:upp HAMAP-Rule MF_01218 EMBL ELY29155.1
Ordered Locus Names:Nmag_1720 EMBL ADD05296.1
ORF Names:C500_11745 EMBL ELY29155.1
OrganismNatrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) (Natronobacterium magadii) [Complete proteome] [HAMAP] EMBL ADD05296.1
Taxonomic identifier547559 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natrialba ›

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP-Rule MF_01218

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01218

Cofactor

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity. HAMAP-Rule MF_01218

Enzyme regulation

Allosterically activated by GTP By similarity. HAMAP-Rule MF_01218

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP-Rule MF_01218

Sequence similarities

Belongs to the UPRTase family. HAMAP-Rule MF_01218

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding36 – 405GTP By similarity HAMAP-Rule MF_01218
Region145 – 15395-phospho-alpha-D-ribose 1-diphosphate binding By similarity HAMAP-Rule MF_01218
Region215 – 2173Uracil binding By similarity HAMAP-Rule MF_01218

Sites

Binding site8615-phospho-alpha-D-ribose 1-diphosphate By similarity HAMAP-Rule MF_01218
Binding site11115-phospho-alpha-D-ribose 1-diphosphate By similarity HAMAP-Rule MF_01218
Binding site2101Uracil; via amide nitrogen By similarity HAMAP-Rule MF_01218
Binding site21615-phospho-alpha-D-ribose 1-diphosphate By similarity HAMAP-Rule MF_01218

Sequences

Sequence LengthMass (Da)Tools
D3SUN8 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 087312D3DB0E6EC6

FASTA22524,706
        10         20         30         40         50         60 
MPIEDRDDAY LVTHALAKHT LSQLRDVQTE QVSFRKGLVK LGRICGYEII DGRMETEYVE 

        70         80         90        100        110        120 
IDTPLEPTMG EQVRGLDDVV IINVLRAATP FVEGLLKAFP RARQGVISAS RDEEAGREDD 

       130        140        150        160        170        180 
GSFPITVDYV KLPEITEDDT VIIADPMLAT GSTMCTVLDH VIENSPEPEN LIVLSAVSAP 

       190        200        210        220 
EGLLRVDDEF PEADLLTVSI DDYLDDDGFI VPGLGDAGDR AFRTT

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of chromosome of Natrialba magadii ATCC 43099."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E., Maupin-Furlow J.A., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3.
[2]"A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T."
Siddaramappa S., Challacombe J.F., Decastro R.E., Pfeiffer F., Sastre D.E., Gimenez M.I., Paggi R.A., Detter J.C., Davenport K.W., Goodwin L.A., Kyrpides N., Tapia R., Pitluck S., Lucas S., Woyke T., Maupin-Furlow J.A.
BMC Genomics 13:165-165(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ATCC 43099 EMBL ADD05296.1.
[3]Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MS-3 EMBL ELY29155.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001932 Genomic DNA. Translation: ADD05296.1.
AOHS01000038 Genomic DNA. Translation: ELY29155.1.
RefSeqYP_003479858.1. NC_013922.1.

3D structure databases

ProteinModelPortalD3SUN8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADD05296; ADD05296; Nmag_1720.
GeneID8824560.
KEGGnmg:Nmag_1720.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000262755.
KOK00761.
OMAYEVTRDM.

Enzyme and pathway databases

BioCycNMAG547559:GJAP-1746-MONOMER.
UniPathwayUPA00574; UER00636.

Family and domain databases

HAMAPMF_01218_A. Upp_A.
InterProIPR000836. PRibTrfase_dom.
IPR005765. Ura_phspho_trans.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01091. upp. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD3SUN8_NATMM
AccessionPrimary (citable) accession number: D3SUN8
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info