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Protein

Isocitrate dehydrogenase [NADP]

Gene

Thal_0646

Organism
Thermocrinis albus (strain DSM 14484 / JCM 11386 / HI 11/12)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Enzyme and pathway databases

BioCyciTALB638303:GHKY-664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Thal_0646Imported
OrganismiThermocrinis albus (strain DSM 14484 / JCM 11386 / HI 11/12)Imported
Taxonomic identifieri638303 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeThermocrinis
ProteomesiUP000002043: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD3SQ42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiAMMLEYL.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3SQ42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLERVYRWEG KAVLPQEGSF IKLLPDKRIE VPHNPIIPFI EGDGIGPEIA
60 70 80 90 100
PAMILVVNRA VEKAYGGSRL IYWVELLAGD KAEALTGKRM PEETLEVLKE
110 120 130 140 150
AVVSIKGPLG TPVGKGGKSL NAILRQSMDF YSAIRPVYWL GQPAPIPEPH
160 170 180 190 200
RVNVTVFREN SDDVYMGIEY MPGSQDTQKV RKFFLEEMGV SPYALPEDCG
210 220 230 240 250
ITVKPMSEYK TKRHVRKALR YALEKGLKVV AVVGKGNIMK ATEGAFMNWA
260 270 280 290 300
FEVAKEPEFE GRVITEGEPK DGQVLLTRVI TDQMLMQLVL KPEAYHVIIT
310 320 330 340 350
QNLNGDYISD LAAALVGGPG FVPSGNIGDG YALFESTHGT AYDIAGKNIA
360 370 380 390 400
NPLSLTLSGA MMLEYLGWKE AAQLIYDAVK KAIEDRLGTP DIAKGFEKMG
410
VEAKALSTME FAQAIAERI
Length:419
Mass (Da):46,060
Last modified:April 20, 2010 - v1
Checksum:i7A762876777E6A81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001931 Genomic DNA. Translation: ADC89279.1.
RefSeqiWP_012991686.1. NC_013894.1.
YP_003473406.1. NC_013894.1.

Genome annotation databases

EnsemblBacteriaiADC89279; ADC89279; Thal_0646.
GeneIDi8814146.
KEGGital:Thal_0646.
PATRICi32507538. VBITheAlb52854_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001931 Genomic DNA. Translation: ADC89279.1.
RefSeqiWP_012991686.1. NC_013894.1.
YP_003473406.1. NC_013894.1.

3D structure databases

ProteinModelPortaliD3SQ42.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC89279; ADC89279; Thal_0646.
GeneIDi8814146.
KEGGital:Thal_0646.
PATRICi32507538. VBITheAlb52854_0644.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiAMMLEYL.

Enzyme and pathway databases

BioCyciTALB638303:GHKY-664-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14484 / JCM 11386 / HI 11/12Imported.

Entry informationi

Entry nameiD3SQ42_THEAH
AccessioniPrimary (citable) accession number: D3SQ42
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.