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D3SBL6

- D3SBL6_THISK

UniProt

D3SBL6 - D3SBL6_THISK

Protein

Alanine racemase

Gene

TK90_1930

Organism
Thioalkalivibrio sp. (strain K90mix)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei130 – 1301SubstrateUniRule annotation
    Active sitei265 – 2651Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei313 – 3131Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTSP396595:GH8D-1975-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:TK90_1930Imported
    OrganismiThioalkalivibrio sp. (strain K90mix)Imported
    Taxonomic identifieri396595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
    ProteomesiUP000009099: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3SBL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031446.
    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3SBL6-1 [UniParc]FASTAAdd to Basket

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    MRRAASIQLH PEALRHNLSV ARRLAPAVPM WSVIKAEGYG HGLLWAAQAL    50
    ADDSDGLAVS QVCEARALRA AGFEGALLVL QGPRDLSEVH ACTEFDLQPV 100
    LHHSAQLDHL EAASVVLPVV WIKLNTGMNR LGFEPAQAPK VATRLQAAGH 150
    GQGGLHWMTH MACADEPEHP QNARQLDAFA TTVAAFPGHR SVANSAALFA 200
    GWGRGGAAAG EYWGRPGIML YGAHPASVPA EHLPEGPDGD LRPAMTVQAP 250
    IIATQPLAPG STVGYGATWT ADAPGRVGIV AMGYADGYPR HAPSGTPVLV 300
    NGELCPLIGR VSMDMLAVDL SGVPAAQVGD RVTLWGEGLP VERVARAAGT 350
    ISYELLTRVA DRLQPGN 367
    Length:367
    Mass (Da):38,517
    Last modified:April 20, 2010 - v1
    Checksum:i30B852CBF442D3A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001905 Genomic DNA. Translation: ADC72421.1.
    RefSeqiWP_012983296.1. NC_013889.1.
    YP_003461157.1. NC_013889.1.

    Genome annotation databases

    EnsemblBacteriaiADC72421; ADC72421; TK90_1930.
    GeneIDi8807703.
    KEGGitkm:TK90_1930.
    PATRICi32527432. VBIThiSp13812_1914.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001905 Genomic DNA. Translation: ADC72421.1 .
    RefSeqi WP_012983296.1. NC_013889.1.
    YP_003461157.1. NC_013889.1.

    3D structure databases

    ProteinModelPortali D3SBL6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC72421 ; ADC72421 ; TK90_1930 .
    GeneIDi 8807703.
    KEGGi tkm:TK90_1930.
    PATRICi 32527432. VBIThiSp13812_1914.

    Phylogenomic databases

    HOGENOMi HOG000031446.
    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TSP396595:GH8D-1975-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Thioalkalivibrio sp. K90mix."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Foster B., Sun H., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Sorokin D.Y., Muyzer G., Woyke T.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K90mixImported.

    Entry informationi

    Entry nameiD3SBL6_THISK
    AccessioniPrimary (citable) accession number: D3SBL6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3