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Protein

Alanine racemase

Gene

TK90_1930

Organism
Thioalkalivibrio sp. (strain K90mix)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei265 – 2651Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei313 – 3131Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTSP396595:GH8D-1975-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TK90_1930Imported
OrganismiThioalkalivibrio sp. (strain K90mix)Imported
Taxonomic identifieri396595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000009099 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3SBL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3SBL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAASIQLH PEALRHNLSV ARRLAPAVPM WSVIKAEGYG HGLLWAAQAL
60 70 80 90 100
ADDSDGLAVS QVCEARALRA AGFEGALLVL QGPRDLSEVH ACTEFDLQPV
110 120 130 140 150
LHHSAQLDHL EAASVVLPVV WIKLNTGMNR LGFEPAQAPK VATRLQAAGH
160 170 180 190 200
GQGGLHWMTH MACADEPEHP QNARQLDAFA TTVAAFPGHR SVANSAALFA
210 220 230 240 250
GWGRGGAAAG EYWGRPGIML YGAHPASVPA EHLPEGPDGD LRPAMTVQAP
260 270 280 290 300
IIATQPLAPG STVGYGATWT ADAPGRVGIV AMGYADGYPR HAPSGTPVLV
310 320 330 340 350
NGELCPLIGR VSMDMLAVDL SGVPAAQVGD RVTLWGEGLP VERVARAAGT
360
ISYELLTRVA DRLQPGN
Length:367
Mass (Da):38,517
Last modified:April 20, 2010 - v1
Checksum:i30B852CBF442D3A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001905 Genomic DNA. Translation: ADC72421.1.
RefSeqiWP_012983296.1. NC_013889.1.
YP_003461157.1. NC_013889.1.

Genome annotation databases

EnsemblBacteriaiADC72421; ADC72421; TK90_1930.
KEGGitkm:TK90_1930.
PATRICi32527432. VBIThiSp13812_1914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001905 Genomic DNA. Translation: ADC72421.1.
RefSeqiWP_012983296.1. NC_013889.1.
YP_003461157.1. NC_013889.1.

3D structure databases

ProteinModelPortaliD3SBL6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC72421; ADC72421; TK90_1930.
KEGGitkm:TK90_1930.
PATRICi32527432. VBIThiSp13812_1914.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciTSP396595:GH8D-1975-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Thioalkalivibrio sp. K90mix."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Foster B., Sun H., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Sorokin D.Y., Muyzer G., Woyke T.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K90mixImported.

Entry informationi

Entry nameiD3SBL6_THISK
AccessioniPrimary (citable) accession number: D3SBL6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 1, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.