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Protein

Isocitrate dehydrogenase [NADP]

Gene

TK90_1264

Organism
Thioalkalivibrio sp. (strain K90mix)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTSP396595:GH8D-1299-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:TK90_1264Imported
OrganismiThioalkalivibrio sp. (strain K90mix)Imported
Taxonomic identifieri396595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000009099 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD3S9R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3S9R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYQHIQVPE KGERITVDEQ GKLVVPDRPI IPFIEGDGIG VDITPVMRRV
60 70 80 90 100
TDAAVEKAYG GQKAIEWMEV YAGEKATQVY DDNSGLPEET LEAVKDYRVS
110 120 130 140 150
IKGPLTTPVG GGFRSLNVAL RQKLDLFVCL RPVRYYDGTP SPLKEPEKTD
160 170 180 190 200
MVIFRENSED IYAGIEFESG TPEVKKVIDF LQNEMGVTQI RFPDTAGIGV
210 220 230 240 250
KPVSSEGTKR LVRKAIEYAI DNDRPSVTLV HKGNIMKFTE GSFKAWGYEL
260 270 280 290 300
AREEFGAKDL DGGPWQTFKN PKTGREIVIK DVIADAFLQQ ILLRPEDYSV
310 320 330 340 350
IATLNLNGDY ISDALAAQVG GIGIAPGANL SDTTAMFEAT HGTAPKYAGQ
360 370 380 390 400
DKVNPGSLIL SAEMMLRHLG WSEAADRVVK GMGGAISAGE VTYDFARLMD
410
NVEPVSCSAF GEALIKHM
Length:418
Mass (Da):45,727
Last modified:April 20, 2010 - v1
Checksum:iE90E2DFD48FAE0C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001905 Genomic DNA. Translation: ADC71773.1.
RefSeqiWP_012982663.1. NC_013889.1.
YP_003460509.1. NC_013889.1.

Genome annotation databases

EnsemblBacteriaiADC71773; ADC71773; TK90_1264.
KEGGitkm:TK90_1264.
PATRICi32526092. VBIThiSp13812_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001905 Genomic DNA. Translation: ADC71773.1.
RefSeqiWP_012982663.1. NC_013889.1.
YP_003460509.1. NC_013889.1.

3D structure databases

ProteinModelPortaliD3S9R8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC71773; ADC71773; TK90_1264.
KEGGitkm:TK90_1264.
PATRICi32526092. VBIThiSp13812_1252.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Enzyme and pathway databases

BioCyciTSP396595:GH8D-1299-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Thioalkalivibrio sp. K90mix."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Foster B., Sun H., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Sorokin D.Y., Muyzer G., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K90mixImported.

Entry informationi

Entry nameiD3S9R8_THISK
AccessioniPrimary (citable) accession number: D3S9R8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 1, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.