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D3S9R8

- D3S9R8_THISK

UniProt

D3S9R8 - D3S9R8_THISK

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Protein

Isocitrate dehydrogenase [NADP]

Gene

TK90_1264

Organism
Thioalkalivibrio sp. (strain K90mix)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTSP396595:GH8D-1299-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:TK90_1264Imported
OrganismiThioalkalivibrio sp. (strain K90mix)Imported
Taxonomic identifieri396595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000009099: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD3S9R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3S9R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYQHIQVPE KGERITVDEQ GKLVVPDRPI IPFIEGDGIG VDITPVMRRV
60 70 80 90 100
TDAAVEKAYG GQKAIEWMEV YAGEKATQVY DDNSGLPEET LEAVKDYRVS
110 120 130 140 150
IKGPLTTPVG GGFRSLNVAL RQKLDLFVCL RPVRYYDGTP SPLKEPEKTD
160 170 180 190 200
MVIFRENSED IYAGIEFESG TPEVKKVIDF LQNEMGVTQI RFPDTAGIGV
210 220 230 240 250
KPVSSEGTKR LVRKAIEYAI DNDRPSVTLV HKGNIMKFTE GSFKAWGYEL
260 270 280 290 300
AREEFGAKDL DGGPWQTFKN PKTGREIVIK DVIADAFLQQ ILLRPEDYSV
310 320 330 340 350
IATLNLNGDY ISDALAAQVG GIGIAPGANL SDTTAMFEAT HGTAPKYAGQ
360 370 380 390 400
DKVNPGSLIL SAEMMLRHLG WSEAADRVVK GMGGAISAGE VTYDFARLMD
410
NVEPVSCSAF GEALIKHM
Length:418
Mass (Da):45,727
Last modified:April 20, 2010 - v1
Checksum:iE90E2DFD48FAE0C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001905 Genomic DNA. Translation: ADC71773.1.
RefSeqiWP_012982663.1. NC_013889.1.
YP_003460509.1. NC_013889.1.

Genome annotation databases

EnsemblBacteriaiADC71773; ADC71773; TK90_1264.
GeneIDi8807028.
KEGGitkm:TK90_1264.
PATRICi32526092. VBIThiSp13812_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001905 Genomic DNA. Translation: ADC71773.1 .
RefSeqi WP_012982663.1. NC_013889.1.
YP_003460509.1. NC_013889.1.

3D structure databases

ProteinModelPortali D3S9R8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC71773 ; ADC71773 ; TK90_1264 .
GeneIDi 8807028.
KEGGi tkm:TK90_1264.
PATRICi 32526092. VBIThiSp13812_1252.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.

Enzyme and pathway databases

BioCyci TSP396595:GH8D-1299-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Thioalkalivibrio sp. K90mix."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Foster B., Sun H., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Sorokin D.Y., Muyzer G., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K90mixImported.

Entry informationi

Entry nameiD3S9R8_THISK
AccessioniPrimary (citable) accession number: D3S9R8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3