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D3S9R8

- D3S9R8_THISK

UniProt

D3S9R8 - D3S9R8_THISK

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Protein
Isocitrate dehydrogenase [NADP]
Gene
TK90_1264
Organism
Thioalkalivibrio sp. (strain K90mix)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTSP396595:GH8D-1299-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:TK90_1264Imported
OrganismiThioalkalivibrio sp. (strain K90mix)Imported
Taxonomic identifieri396595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000009099: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD3S9R8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3S9R8-1 [UniParc]FASTAAdd to Basket

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MAYQHIQVPE KGERITVDEQ GKLVVPDRPI IPFIEGDGIG VDITPVMRRV    50
TDAAVEKAYG GQKAIEWMEV YAGEKATQVY DDNSGLPEET LEAVKDYRVS 100
IKGPLTTPVG GGFRSLNVAL RQKLDLFVCL RPVRYYDGTP SPLKEPEKTD 150
MVIFRENSED IYAGIEFESG TPEVKKVIDF LQNEMGVTQI RFPDTAGIGV 200
KPVSSEGTKR LVRKAIEYAI DNDRPSVTLV HKGNIMKFTE GSFKAWGYEL 250
AREEFGAKDL DGGPWQTFKN PKTGREIVIK DVIADAFLQQ ILLRPEDYSV 300
IATLNLNGDY ISDALAAQVG GIGIAPGANL SDTTAMFEAT HGTAPKYAGQ 350
DKVNPGSLIL SAEMMLRHLG WSEAADRVVK GMGGAISAGE VTYDFARLMD 400
NVEPVSCSAF GEALIKHM 418
Length:418
Mass (Da):45,727
Last modified:April 20, 2010 - v1
Checksum:iE90E2DFD48FAE0C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001905 Genomic DNA. Translation: ADC71773.1.
RefSeqiWP_012982663.1. NC_013889.1.
YP_003460509.1. NC_013889.1.

Genome annotation databases

EnsemblBacteriaiADC71773; ADC71773; TK90_1264.
GeneIDi8807028.
KEGGitkm:TK90_1264.
PATRICi32526092. VBIThiSp13812_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001905 Genomic DNA. Translation: ADC71773.1 .
RefSeqi WP_012982663.1. NC_013889.1.
YP_003460509.1. NC_013889.1.

3D structure databases

ProteinModelPortali D3S9R8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC71773 ; ADC71773 ; TK90_1264 .
GeneIDi 8807028.
KEGGi tkm:TK90_1264.
PATRICi 32526092. VBIThiSp13812_1252.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.

Enzyme and pathway databases

BioCyci TSP396595:GH8D-1299-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Thioalkalivibrio sp. K90mix."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Foster B., Sun H., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Sorokin D.Y., Muyzer G., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K90mix.

Entry informationi

Entry nameiD3S9R8_THISK
AccessioniPrimary (citable) accession number: D3S9R8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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