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D3S9R8

- D3S9R8_THISK

UniProt

D3S9R8 - D3S9R8_THISK

Protein

Isocitrate dehydrogenase [NADP]

Gene

TK90_1264

Organism
Thioalkalivibrio sp. (strain K90mix)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciTSP396595:GH8D-1299-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:TK90_1264Imported
    OrganismiThioalkalivibrio sp. (strain K90mix)Imported
    Taxonomic identifieri396595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
    ProteomesiUP000009099: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD3S9R8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3S9R8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYQHIQVPE KGERITVDEQ GKLVVPDRPI IPFIEGDGIG VDITPVMRRV    50
    TDAAVEKAYG GQKAIEWMEV YAGEKATQVY DDNSGLPEET LEAVKDYRVS 100
    IKGPLTTPVG GGFRSLNVAL RQKLDLFVCL RPVRYYDGTP SPLKEPEKTD 150
    MVIFRENSED IYAGIEFESG TPEVKKVIDF LQNEMGVTQI RFPDTAGIGV 200
    KPVSSEGTKR LVRKAIEYAI DNDRPSVTLV HKGNIMKFTE GSFKAWGYEL 250
    AREEFGAKDL DGGPWQTFKN PKTGREIVIK DVIADAFLQQ ILLRPEDYSV 300
    IATLNLNGDY ISDALAAQVG GIGIAPGANL SDTTAMFEAT HGTAPKYAGQ 350
    DKVNPGSLIL SAEMMLRHLG WSEAADRVVK GMGGAISAGE VTYDFARLMD 400
    NVEPVSCSAF GEALIKHM 418
    Length:418
    Mass (Da):45,727
    Last modified:April 20, 2010 - v1
    Checksum:iE90E2DFD48FAE0C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001905 Genomic DNA. Translation: ADC71773.1.
    RefSeqiWP_012982663.1. NC_013889.1.
    YP_003460509.1. NC_013889.1.

    Genome annotation databases

    EnsemblBacteriaiADC71773; ADC71773; TK90_1264.
    GeneIDi8807028.
    KEGGitkm:TK90_1264.
    PATRICi32526092. VBIThiSp13812_1252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001905 Genomic DNA. Translation: ADC71773.1 .
    RefSeqi WP_012982663.1. NC_013889.1.
    YP_003460509.1. NC_013889.1.

    3D structure databases

    ProteinModelPortali D3S9R8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC71773 ; ADC71773 ; TK90_1264 .
    GeneIDi 8807028.
    KEGGi tkm:TK90_1264.
    PATRICi 32526092. VBIThiSp13812_1252.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci TSP396595:GH8D-1299-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Thioalkalivibrio sp. K90mix."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Foster B., Sun H., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Sorokin D.Y., Muyzer G., Woyke T.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K90mixImported.

    Entry informationi

    Entry nameiD3S9R8_THISK
    AccessioniPrimary (citable) accession number: D3S9R8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3