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D3S8C7

- HPRT_METSF

UniProt

D3S8C7 - HPRT_METSF

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene
hpt, MFS40622_0597
Organism
Methanocaldococcus sp. (strain FS406-22)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMSP644281:GI4H-604-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:MFS40622_0597
OrganismiMethanocaldococcus sp. (strain FS406-22)
Taxonomic identifieri644281 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000002189: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotationPRO_0000415468Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3S8C7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228520.
KOiK00759.
OMAiMIAIINA.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3S8C7-1 [UniParc]FASTAAdd to Basket

« Hide

MFIKCYSGGG RLLLEETLKS CPIVKRGQYH YFIHPISDGV PLVEPKLLRE    50
VAMRIIKIGN FEDVDKLVTA EAMGIPLVTT LSLYTDIPYV IMRKREYKLP 100
GEIPVFQSTG YSKGQLYLNG IEKGDKVVII DDVISTGGTM IAIINALKRA 150
GAEIKDIICV IERGEGKKIV EEKTGYKIKT LVKIDVVDGK VVILRD 196
Length:196
Mass (Da):21,813
Last modified:April 20, 2010 - v1
Checksum:i2E7FE77448AF2532
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001901 Genomic DNA. Translation: ADC69287.1.
RefSeqiWP_012980197.1. NC_013887.1.
YP_003458023.1. NC_013887.1.

Genome annotation databases

EnsemblBacteriaiADC69287; ADC69287; MFS40622_0597.
GeneIDi8804438.
KEGGimfs:MFS40622_0597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001901 Genomic DNA. Translation: ADC69287.1 .
RefSeqi WP_012980197.1. NC_013887.1.
YP_003458023.1. NC_013887.1.

3D structure databases

ProteinModelPortali D3S8C7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC69287 ; ADC69287 ; MFS40622_0597 .
GeneIDi 8804438.
KEGGi mfs:MFS40622_0597.

Phylogenomic databases

HOGENOMi HOG000228520.
KOi K00759.
OMAi MIAIINA.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MSP644281:GI4H-604-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methanocaldococcus sp. FS406-22."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Leigh J., Whitman W.B., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FS406-22.

Entry informationi

Entry nameiHPRT_METSF
AccessioniPrimary (citable) accession number: D3S8C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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