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D3S8C7

- HPRT_METSF

UniProt

D3S8C7 - HPRT_METSF

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanocaldococcus sp. (strain FS406-22)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMSP644281:GI4H-604-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:MFS40622_0597
OrganismiMethanocaldococcus sp. (strain FS406-22)
Taxonomic identifieri644281 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000002189: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415468Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3S8C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228520.
KOiK00759.
OMAiMIAIINA.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3S8C7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFIKCYSGGG RLLLEETLKS CPIVKRGQYH YFIHPISDGV PLVEPKLLRE
60 70 80 90 100
VAMRIIKIGN FEDVDKLVTA EAMGIPLVTT LSLYTDIPYV IMRKREYKLP
110 120 130 140 150
GEIPVFQSTG YSKGQLYLNG IEKGDKVVII DDVISTGGTM IAIINALKRA
160 170 180 190
GAEIKDIICV IERGEGKKIV EEKTGYKIKT LVKIDVVDGK VVILRD
Length:196
Mass (Da):21,813
Last modified:April 20, 2010 - v1
Checksum:i2E7FE77448AF2532
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001901 Genomic DNA. Translation: ADC69287.1.
RefSeqiWP_012980197.1. NC_013887.1.
YP_003458023.1. NC_013887.1.

Genome annotation databases

EnsemblBacteriaiADC69287; ADC69287; MFS40622_0597.
GeneIDi8804438.
KEGGimfs:MFS40622_0597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001901 Genomic DNA. Translation: ADC69287.1 .
RefSeqi WP_012980197.1. NC_013887.1.
YP_003458023.1. NC_013887.1.

3D structure databases

ProteinModelPortali D3S8C7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC69287 ; ADC69287 ; MFS40622_0597 .
GeneIDi 8804438.
KEGGi mfs:MFS40622_0597.

Phylogenomic databases

HOGENOMi HOG000228520.
KOi K00759.
OMAi MIAIINA.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MSP644281:GI4H-604-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methanocaldococcus sp. FS406-22."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Leigh J., Whitman W.B., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FS406-22.

Entry informationi

Entry nameiHPRT_METSF
AccessioniPrimary (citable) accession number: D3S8C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3