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Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Methanocaldococcus sp. (strain FS406-22)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: pimeloyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pimeloyl-CoA from pimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-carboxyhexanoate--CoA ligase (bioW)
This subpathway is part of the pathway pimeloyl-CoA biosynthesis, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pimeloyl-CoA from pimelate, the pathway pimeloyl-CoA biosynthesis and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processBiotin biosynthesis
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP644281:G1GHG-359-MONOMER
UniPathwayiUPA00999; UER00351

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
Ordered Locus Names:MFS40622_0356
OrganismiMethanocaldococcus sp. (strain FS406-22)
Taxonomic identifieri644281 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002189 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004120961 – 2336-carboxyhexanoate--CoA ligaseAdd BLAST233

Proteomic databases

PRIDEiD3S7P2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi644281.MFS40622_0356

Structurei

3D structure databases

SMRiD3S7P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG05075 Archaea
COG1424 LUCA
HOGENOMiHOG000253976
KOiK01906
OMAiLCWSDDP
OrthoDBiPOG093Z0BPI

Family and domain databases

HAMAPiMF_00668 BioW, 1 hit
InterProiView protein in InterPro
IPR005499 BioW
PfamiView protein in Pfam
PF03744 BioW, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017229 BioW, 1 hit
TIGRFAMsiTIGR01204 bioW, 1 hit

Sequencei

Sequence statusi: Complete.

D3S7P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSIKMRASK NGKHISGAER IVNKDEIEDV ARELIKRALT HENGTPDFIN
60 70 80 90 100
IKIEEIKEDI EYIDHLPIKT IHCKNKEEAR EKAREILRNE GIPDKVIDYA
110 120 130 140 150
YEIIDKGGMR GAAILNLKGE RLEPDKERGV RVKNIDTTKE LKEKILKEKL
160 170 180 190 200
GTERTVDAIA IASKVIHLGV IAELCTSDNK SYTTGYVATK RGYFRITNLK
210 220 230
KEGESGGRVF FVKNDVNIED LIDKLENKPF IIK
Length:233
Mass (Da):26,564
Last modified:April 20, 2010 - v1
Checksum:i3C435988EF25C885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001901 Genomic DNA Translation: ADC69052.1
RefSeqiWP_012979963.1, NC_013887.1

Genome annotation databases

EnsemblBacteriaiADC69052; ADC69052; MFS40622_0356
GeneIDi8804195
KEGGimfs:MFS40622_0356

Similar proteinsi

Entry informationi

Entry nameiBIOW_METSF
AccessioniPrimary (citable) accession number: D3S7P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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