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Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Methanocaldococcus sp. (strain FS406-22)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: pimeloyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pimeloyl-CoA from pimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-carboxyhexanoate--CoA ligase (bioW)
This subpathway is part of the pathway pimeloyl-CoA biosynthesis, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pimeloyl-CoA from pimelate, the pathway pimeloyl-CoA biosynthesis and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP644281:GI4H-361-MONOMER.
UniPathwayiUPA00999; UER00351.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
Ordered Locus Names:MFS40622_0356
OrganismiMethanocaldococcus sp. (strain FS406-22)
Taxonomic identifieri644281 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002189 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2332336-carboxyhexanoate--CoA ligasePRO_0000412096Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi644281.MFS40622_0356.

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG05075. Archaea.
COG1424. LUCA.
HOGENOMiHOG000253976.
KOiK01906.
OMAiLCWSDDP.

Family and domain databases

HAMAPiMF_00668. BioW.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]
ProDomiPD017229. BioW. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01204. bioW. 1 hit.

Sequencei

Sequence statusi: Complete.

D3S7P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSIKMRASK NGKHISGAER IVNKDEIEDV ARELIKRALT HENGTPDFIN
60 70 80 90 100
IKIEEIKEDI EYIDHLPIKT IHCKNKEEAR EKAREILRNE GIPDKVIDYA
110 120 130 140 150
YEIIDKGGMR GAAILNLKGE RLEPDKERGV RVKNIDTTKE LKEKILKEKL
160 170 180 190 200
GTERTVDAIA IASKVIHLGV IAELCTSDNK SYTTGYVATK RGYFRITNLK
210 220 230
KEGESGGRVF FVKNDVNIED LIDKLENKPF IIK
Length:233
Mass (Da):26,564
Last modified:April 20, 2010 - v1
Checksum:i3C435988EF25C885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001901 Genomic DNA. Translation: ADC69052.1.
RefSeqiWP_012979963.1. NC_013887.1.

Genome annotation databases

EnsemblBacteriaiADC69052; ADC69052; MFS40622_0356.
GeneIDi8804195.
KEGGimfs:MFS40622_0356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001901 Genomic DNA. Translation: ADC69052.1.
RefSeqiWP_012979963.1. NC_013887.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi644281.MFS40622_0356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC69052; ADC69052; MFS40622_0356.
GeneIDi8804195.
KEGGimfs:MFS40622_0356.

Phylogenomic databases

eggNOGiarCOG05075. Archaea.
COG1424. LUCA.
HOGENOMiHOG000253976.
KOiK01906.
OMAiLCWSDDP.

Enzyme and pathway databases

UniPathwayiUPA00999; UER00351.
BioCyciMSP644281:GI4H-361-MONOMER.

Family and domain databases

HAMAPiMF_00668. BioW.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]
ProDomiPD017229. BioW. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01204. bioW. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Methanocaldococcus sp. FS406-22."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Leigh J., Whitman W.B., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FS406-22.

Entry informationi

Entry nameiBIOW_METSF
AccessioniPrimary (citable) accession number: D3S7P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 20, 2010
Last modified: November 11, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.