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Protein

Tetrahydromethanopterin S-methyltransferase subunit F

Gene

mtrF

Organism
Methanocaldococcus sp. (strain FS406-22)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.UniRule annotation

Catalytic activityi

5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate.UniRule annotation

Pathwayi: methanogenesis from CO(2)

This protein is involved in step 2 of the subpathway that synthesizes methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 5,10-methylenetetrahydromethanopterin reductase (mer)
  2. Tetrahydromethanopterin S-methyltransferase subunit B (mtrB), Tetrahydromethanopterin S-methyltransferase subunit C (mtrC), Tetrahydromethanopterin S-methyltransferase subunit F (mtrF), Tetrahydromethanopterin S-methyltransferase subunit A (mtrA), Tetrahydromethanopterin S-methyltransferase subunit H (mtrH), Tetrahydromethanopterin S-methyltransferase subunit G (mtrG), Tetrahydromethanopterin S-methyltransferase subunit D (mtrD), Tetrahydromethanopterin S-methyltransferase subunit E (mtrE)
This subpathway is part of the pathway methanogenesis from CO(2), which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin, the pathway methanogenesis from CO(2) and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotationImported, Transferase
Biological processMethanogenesisUniRule annotation, One-carbon metabolismUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00640; UER00698.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetrahydromethanopterin S-methyltransferase subunit FUniRule annotation (EC:2.1.1.86UniRule annotation)
Alternative name(s):
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit FUniRule annotation
Gene namesi
Name:mtrFUniRule annotation
Ordered Locus Names:MFS40622_1309Imported
OrganismiMethanocaldococcus sp. (strain FS406-22)Imported
Taxonomic identifieri644281 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002189 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 67HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.UniRule annotation

Protein-protein interaction databases

STRINGi644281.MFS40622_1309.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 63MtrFInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the MtrF family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiarCOG03381. Archaea.
COG4218. LUCA.
HOGENOMiHOG000229653.
KOiK00582.
OMAiYMEELEY.
OrthoDBiPOG093Z0LWO.

Family and domain databases

HAMAPiMF_01099. MtrF. 1 hit.
InterProiView protein in InterPro
IPR011307. MeTrfase_F.
IPR013347. MeTrfase_F_su.
PfamiView protein in Pfam
PF09472. MtrF. 1 hit.
PIRSFiPIRSF006523. MtrF. 1 hit.
TIGRFAMsiTIGR02507. MtrF. 1 hit.

Sequencei

Sequence statusi: Complete.

D3S572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEISNKPN VSSIESYVED LEYKVGLITR NRGLESGVES AGTKGLIIGA
60
VSALVLVGIP LAIYLLMR
Length:68
Mass (Da):7,205
Last modified:April 20, 2010 - v1
Checksum:iD975981E2338D1DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001901 Genomic DNA. Translation: ADC69986.1.
RefSeqiWP_012980894.1. NC_013887.1.

Genome annotation databases

EnsemblBacteriaiADC69986; ADC69986; MFS40622_1309.
GeneIDi8805168.
KEGGimfs:MFS40622_1309.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD3S572_METSF
AccessioniPrimary (citable) accession number: D3S572
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 7, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported